Prognostic value of quantitative flow ratio in patients with coronary heart disease after percutaneous coronary intervention therapy: a meta-analysis

Abstract

BackgroundCoronary atherosclerotic heart disease is one of the most serious health and life-threatening diseases. There is no doubt that despite the increasing number of assessment methods used clinically, the prognosis assessment is still not ideal, and newer assessment methods are needed.ObjectiveTo investigate the predictive value of quantitative flow ratio (QFR) for adverse events (vessel-oriented composite endpoint events/target lesion failure) in patients after percutaneous coronary intervention (PCI).MethodEight studies involving 4,173 patients (5,688 vascular lesions) were included. These are studies on the relationship between QFR values and prognosis of adverse cardiac events after PCI. This meta-analysis was performed after quality assessment and data extraction of clinical trials data that met the inclusion criteria.ResultEach of the eight studies described the cut-off values for the best predictive ability of post-PCI QFR and the hazard ratio (HR) between QFR values and adverse events, respectively. The pooled HR of these studies was 4.72 (95% CI: 3.29–6.75). Concurrently, lower post-PCI QFR values were associated with the occurrence of individual clinical events (cardiac death/myocardial infarction/target vessel revascularization), with relative risk values of 6.51 (95% CI: 4.96–8.53), 4.83 (95% CI: 3.08–7.57), and 4.21 (95% CI: 2.66–6.68), respectively.ConclusionQFR may have great potential in the assessment of prognosis. It is necessary to measure QFR value after PCI. A lower QFR value after PCI was an important predictor for experiencing adverse events.

Validation of Quantitative Flow Ratio-Derived Virtual Angioplasty with Post-Angioplasty Fractional Flow Reserve—The QIMERA-I Study

“…Even in the post-PCI setting QFR seems an effective technique and can be used to drive prognostic intervention decision making, with lower post-PCI QFR values accurately predicting adverse clinical outcomes [27]. As discussed by Chen et al, post-PCI QFR assessment showed a solid predictive value over future adverse cardiovascular events and this finding was confirmed by another large meta-analysis, with a 58% risk reduction per each 0.1 increase in the post-PCI QFR value [28,29]. In this context, compared with wire-based physiology, QFR has a theoretical additional advantage, as it may allow to predict beforehand the functional result of the angioplasty.…”

Advancements in Myocardial Infarction Management: Exploring Novel Approaches and Strategies

“…As the polymer gradually resorbs, the vessel regains its natural structure and function. Clinical trials, including ABSORB III and ABSORB IV, have assessed the safety and efficacy of BVS in comparison to metallic drug-eluting stents [31]. These trials have demonstrated similar rates of target lesion failure between BVS and metallic stents at short-term follow-up.…”

“…This technology allows for the early detection of arrhythmias or ST-segment changes, enabling prompt intervention. For example, the Apple Watch's ECG feature has been shown to accurately detect atrial fibrillation, a common arrhythmia associated with post-MI complications [31].…”

“…Their user-friendly interfaces and accessibility on smartphones make them convenient tools for both patients and healthcare professionals. Medication adherence is a critical component of post-MI care, as prescribed medications help prevent recurrent cardiovascular events [31]. Mobile apps can provide patients with medication reminders and educational resources about their medications, improving adherence rates.…”