Prognostic value of red blood cell distribution width-standard deviation (RDW-SD) in patients operated on due to non-small cell lung cancer

Abstract

Background: The aim of the study was to determine a survival prognostic value of selected blood morphological rates of patients, operated on due to non-small cell lung cancer (NSCLC). Methods: The study was conducted on 532 patients, surgically treated due to NSCLC, in stages IA-IIIA, 174 females and 358 males, mean age 63.6 years (36-84 years) were included in the study. Blood parameters and clinical factors were included in statistical analysis, in order to determine potential prognostic values of red blood cell distribution width-standard deviation (RDW-SD), mean corpuscular volume (MCV) of red cell and hemoglobin. Factors contained: age, sex, smoking history, histopathological diagnosis , T category, N category, age-adjusted Charlson Comorbidity Index (CCI), number of lymphocytes, neutrophils, monocytes, platelets, the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR), kind of surgery, patient survival. Results:The univariate analysis revealed a dependence of the value of RDW-SD and CCI values, the number of monocytes, NLR and PLR values, neoplasia stage and the overall survival. The multivariate analysis confirmed that not only N2 category and the value of CCI above 4 are negative prognostication factors, but also RDW-SD above 43 fL (P=0.00007) and PLR above 138 (P=0.001) are such negative factors of survival prognosis. Conclusions: RDW-SD is an independent and significant prognostic factor of patients' survival operated on due to NSCLC.

Assessing the Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Stage I Non-Small-Cell Lung Cancer with Complete Resection

“…[17][18][19]. RDW-SD ≥43 was negatively correlated with NSCLC survival [20]. Recent studies have found that stage I NSCLC with elevated RDW-SD had short PFS and OS, which was similarly con rmed in our current study [21,22].…”

“…The previous study which included 1387 postoperative patients with stage I NSCLC indicated that lymphovascular invasion was an adverse factor for postoperative recurrence and death, and Mollberg et al and Mitchell et al similarly indicated that stage I lung cancer with positive lymphovascular invasion had a poor prognosis, which was in agreement with the results of our study [ 17 – 19 ]. RDW-SD ≥43 fl was negatively correlated with NSCLC survival [ 20 ]. Recent studies have found that stage I NSCLC with elevated RDW-SD had short PFS and OS, which was similarly confirmed in our current study [ 21 , 22 ].…”

The prognostic value of RDW, NLR and PLR in sequential radio-chemotherapy for advanced lung cancer

“…Multiple studies indicate that blood morphology indices, such as red blood cell distribution width (RDW) [6][7][8][9][10][11][12][13], neutrophil-to-lymphocyte ratio (NLR) [14][15][16][17][18][19], and platelet-to--lymphocyte ratio (PLR) [6,[19][20][21], may be prognostic factors in cancer patients. Such indices could be particularly useful for clinicians given that the majority are based on routinely performed laboratory tests.…”

Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnancy women

“…The red blood cell distribution width (RDW), including RDW-coefficient of variation (CV) and RDW-standard deviation (SD), as simple and widely available hematological indices, is easily acquired from a routine blood test and reflects the degree of heterogeneity of erythrocyte size [ 5 ]. Traditionally, RDW-CV is used to explore the cause of underlying anemia, especially for differential diagnosis of IDA [ 6 , 7 ].…”