Prognostic Value of Red Blood Cell Distribution Width in Prediction of In-Hospital Mortality in Patients with Acute Myocardial Infarction

Sangoi, Manuela B.; Guarda, Naiara dos Santos; Rödel, A.; Zorzo, Pietra; Borges, P Rafael; Cargnin, Lara; Carvalho, J Forte De; Premaor, Melissa Orlandin

doi:10.7754/clin.lab.2013.130907

Cited by 14 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have found significantly higher RDW values in stent thrombosis group, and RDW was found to be an independent predictor of stent thrombosis. Sangoi et al [ 22 ] showed that RDW was an independent predictor of in-hospital mortality in 109 patients with acute myocardial infarction. Acet et al [ 23 ] demonstrated that there was significant strong correlation between Global Registry of Acute Coronary Events score and RDW values in 800 STEMI patients.…”

Section: Discussionmentioning

confidence: 99%

Association between RDW and stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Tunçez

Çetin²,

Çetin³

et al. 2017

Medicine

View full text Add to dashboard Cite

Stent thrombosis is a rare but potentially fatal complication of percutaneous coronary interventions (PCIs). In recent years, the predictive and prognostic value of the red cell distribution width (RDW) as an indicator of inflammation has been shown in many cardiovascular diseases. Aim of this study was to examine the predictive value of RDW for stent thrombosis in patients who underwent successful stent implantation for ST-elevation myocardial infarction (STEMI).In this retrospective study, 146 patients who underwent successful PCI to native coronary artery due to STEMI previously and presented with acute coronary syndrome with stent thrombosis were included (stent thrombosis group). A total of 175 patients who had similar procedural characteristics (type, diameter, and length of stent) and not had stent thrombosis were consisted control group.Patients were divided into tertiles according to the admission RDW values (12.9 ± 0.4, 14.2 ± 0.4, and 16.3 ± 1.5, respectively). Stent thrombosis developed in 47 (40.9%) patients in the lowest tertile, 39 (37.9%) patients in mid tertile, and 60 (58.3%) patients in the highest tertile (P = 0.006). Female gender ratio was statistically significantly higher in the 3rd tertile (13 [11.3%], 8 [7.8%], 24 [23.3%], P = 0.003, respectively). RDW (OR: 1.397 [95% CI 1.177–1.657], P < 0.001) and platelet count (OR: 1.008 [95% CI 1.004–1.012], P < 0.001) remained independent predictors of stent thrombosis after multivariate logistic regression analysis. ROC curve analysis demonstrated that, admission RDW values higher than 13.9 can predict the development of stent thrombosis with a sensitivity of 57% and a specificity of 52% (The area under the ROC curve: 0.59 [95% CI 0.53–0.65] P = 0.007).High RDW values found to be independently associated with the development of stent thrombosis in patients with STEMI.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between RDW and stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Tunçez

Çetin²,

Çetin³

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…Tonelli et al determined that RDW was a risk factor for MI, stroke, and symptomatic HF in patients with CAD [ 9 ]. Elevated RDW levels are also associated with increased in-hospital and long-term mortality among patients suffering from MI [ 11 , 12 ]. Lippi et al observed that RDW had diagnostic value in patients admitted to the intensive care unit for chest pain suggestive of acute coronary syndrome.…”

Section: The Prognostic and Diagnostic Value Of Rdw In Cadmentioning

confidence: 99%

“…Subsequent studies have confirmed the significance of RDW as a predictor of mortality both in the general population [ 3 ] and in patients with various diseases, including peripheral artery disease (PAD) [ 4 ], chronic obstructive pulmonary disease (COPD) [ 5 ], and kidney failure [ 6 – 8 ]. In the literature, there exist increasing amounts of data describing the link between RDW and prognosis in patients with stable coronary artery disease (SCAD) [ 9 ], including patients undergoing percutaneous coronary intervention (PCI) [ 10 ] and patients suffering from myocardial infarction (MI) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Role of Red Blood Cell Distribution Width in Coronary Artery Disease: A Review of the Pathophysiology

et al. 2015

View full text Add to dashboard Cite

Red blood cell distribution width (RDW) is a measure of red blood cell volume variations (anisocytosis) and is reported as part of a standard complete blood count. In recent years, numerous studies have noted the importance of RDW as a predictor of poor clinical outcomes in the settings of various diseases, including coronary artery disease (CAD). In this paper, we discuss the prognostic value of RDW in CAD and describe the pathophysiological connection between RDW and acute coronary syndrome. In our opinion, the negative prognostic effects of elevated RDW levels may be attributed to the adverse effects of independent risk factors such as inflammation, oxidative stress, and vitamin D3 and iron deficiency on bone marrow function (erythropoiesis). Elevated RDW values may reflect the intensity of these phenomena and their unfavorable impacts on bone marrow erythropoiesis. Furthermore, decreased red blood cell deformability among patients with higher RDW values impairs blood flow through the microcirculation, resulting in the diminution of oxygen supply at the tissue level, particularly among patients suffering from myocardial infarction treated with urgent revascularization.

show abstract

“…CRP corresponds to the severity of the underlying disease, while RDW is an index of red blood cell size heterogeneity and it is elevated under conditions of ineffective production and increased destruction of erythrocytes due to inflammatory factors or increased oxidative stress [ 21 , 22 ]. Therefore, continued increase in CRP and RDW may reflect unfavorable and uncontrollable disease conditions, which expose patients to higher risk of poorer outcome.…”

Section: Discussionmentioning

confidence: 99%

Combined efficacy of C-reactive protein and red blood cell distribution width in prognosis of patients with culture-negative infective endocarditis

Wei

Liu

et al. 2017

Oncotarget

View full text Add to dashboard Cite

ObjectiveTo evaluate the combined effect of C-reactive protein (CRP) and red blood cell distribution width (RDW) on the prediction of in-hospital and long-term poor outcomes in patients with blood culture-negative infective endocarditis (BCNE).ResultsPatients with high CRP and high RDW has the highest incidence of in-hospital death (2.3% vs. 7.8% vs. 5.6% vs. 17.5%, P < 0.001). CRP > 17.8 mg/L (odds ratio [OR]=2.41, 95% confidence interval [CI], 1.06–5.51, P = 0.037), RDW >16.3 (OR = 2.29, 95% CI, 1.10–4.77, P = 0.027), and these two values in combination (OR = 3.15, 95% CI, 1.46–6.78, P=0.003) were independently associated with in-hospital death. Patients with RDW > 16.3 had higher long-term mortality (P = 0.003), while no significant correlation was observed for CRP (P = 0.151).Materials and MethodsIn total, 572 participants with BCNE were consecutively enrolled. They were classified into four groups based on the optimal CRP and RDW cut-off values (which were determined using a receiver operating characteristic analysis): low CRP and low RDW (n = 216), high CRP and low RDW (n = 129), low CRP and high RDW (n = 107), and high CRP and high RDW (n = 120).ConclusionsIncreased CRP and RDW, especially in combination, are independently associated with in-hospital death in BCNE. RDW, but not CRP, has long-term prognostic value.

show abstract

Prognostic Value of Red Blood Cell Distribution Width in Prediction of In-Hospital Mortality in Patients with Acute Myocardial Infarction

Cited by 14 publications

References 0 publications

Association between RDW and stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Association between RDW and stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

The Prognostic Role of Red Blood Cell Distribution Width in Coronary Artery Disease: A Review of the Pathophysiology

Combined efficacy of C-reactive protein and red blood cell distribution width in prognosis of patients with culture-negative infective endocarditis

Contact Info

Product

Resources

About