Prognostic value of red blood cell distribution width in hepatocellular carcinoma

Goyal, Hemant; Hu, Zhide

doi:10.21037/atm.2017.06.30

Cited by 41 publications

(27 citation statements)

References 28 publications

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“…More recently, increased RDW values have been found to be a negative predictors of survival in several types of malignancies 10 . Some authors have reported correlations between H-RDW and decreased survival in lung 1,2 , gastric 13 , esophageal 14 , hepatocellular cancers 12,19 , and breast cancer 15 . A similar correlation also seems to apply to colorectal cancers 20,21 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of red cell distribution width (RDW) in colorectal cancer. Results from a single-center cohort on 591 patients

Pedrazzani

Tripepi

Turri

et al. 2020

Sci Rep

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Increasing evidence advocates the prognostic role of RDW in various tumours. We analysed 591 patients to assess whether RDW is a prognostic factor for overall (oS) and cancer-related survival (cRS) for patients with colorectal cancer (cRc). the data were retrieved from a retrospective database. the optimal cutoff value for RDW was set at 14.1%; accordingly, two groups were considered: those with a value equal or lower than 14.1% (L-RDW), and those with a value higher than 14.1% (H-RDW). The mean value of RDW rose from pT1 to pT4 tumours. H-RDW correlated with age above the mean, colonic location of the lesion, pT and TNM stage. Finally, H-RDW was significantly associated with the intent of surgery: almost 50% of patients who underwent a non-curative resection presented H-RDW, compared to 19.3% in R0 resections. OS was significantly lower in patients with H-RDW. CRS was similar in the two groups. Stratifying patients according to TNM stage worse OS was associated with H-RDW only in early stages, whereas there was no difference for stages II-IV. Multivariate analysis confirmed that H-RDW was not an independent prognostic factor. Although H-RDW correlated with some negative clinicalpathological factors, it did not seem to independently influence OS and CRS. Colorectal cancer (CRC) is the third most common cancer worldwide, with more than 1 million new cases and 600.000 deaths per year 1. Several biochemical markers related to the inflammatory processes that accompanies this malignancy have recently surged as diagnostic and prognostic tools 2-4. Beside classical 'inflammatory related' markers such as acute phase proteins (CRP and globulins), also parameters that reflect changes in certain bone marrow lineages such as PLR and NLR have been described 2,5. Amongst these, red blood cell distribution width (RDW) is a parameter that reflects the size heterogeneity of red blood cells and is normally used to differentiate various types of anemia 6. More recently, RDW has surged as a biochemical marker in several chronic inflammatory and cardiovascular disease 7-9. Recent reports have shown how it can be used as a prognostic marker in various cancer such as, lung, liver, esophago-gastric and breast 10-15. RDW has been studied as a potential prognostic marker also in CRC. In the context of this malignancy, however, its role remains unclear, as reports so far published have shown inconsistent results. The aim of this retrospective study was to evaluate the prognostic value of red blood cell distribution width in a large cohort of patients undergoing surgery for colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of red cell distribution width (RDW) in colorectal cancer. Results from a single-center cohort on 591 patients

Pedrazzani

Tripepi

Turri

et al. 2020

Sci Rep

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“…Red blood cell distribution width (RDW) is a parameter for routine examination of whole blood counts, which is a quantitative measure of changes in circulating red blood cell size . In addition to routine assessments in the differential diagnosis of anemia, studies have shown that there is a hierarchical independent relationship between high RDW levels and the occurrence of cervical, ovarian, and endometrial cancer .…”

Section: Introductionmentioning

confidence: 99%

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

Zhang

Xie

Zhan

2019

Clinical Laboratory Analysis

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BackgroundRed blood cell distribution width (RDW) has attracted increasing attention in cancer. The aim of this study was to assess the changes of RDW in patients with invasive hydatidiform mole and analyze the relationship between RDW and invasive hydatidiform mole.MethodsA retrospective analysis was performed on 102 patients diagnosed as invasive hydatidiform mole in the First Affiliated Hospital of Guangxi Medical University from January 2009 to March 2018. A total of 120 healthy subjects were used as a control group. The Mann‐Whitney U test was used for comparison between the invasive hydatidiform mole and control groups. Comparison of RDW with other blood parameters was performed using Spearman's. The area under the ROC curve (AUC) and 95% confidence interval (95% CI) were also determined.ResultsThe RDW, platelet‐lymphocyte ratio (PLR), neutrophil‐lymphocyte ratio (NLR), and absolute lymphocyte count were significantly elevated in the invasive hydatidiform mole group compared with control group. The hemoglobin (Hb) concentration, mean red blood cell volume (MCV) and platelet count (PLT) were significantly lower in invasive hydatidiform mole group than control group. Grade III and above invasive hydatidiform mole patients had higher levels of RDW than grade I and II patients. Correlation analysis showed that RDW was negatively correlated with Hb, MCV, NLR, and neutrophil count, but positively correlated with PDW and different stages of invasive hydatidiform mole. The ROC curve showed that the AUC of the RDW was 0.660 (95% CI 0.581‐0.740; P < 0.01).ConclusionThis study reveals the potential value of RDW in invasive hydatidiform mole.

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“…Acute pancreatitis (AP) is one of the most common causes of hospitalization due to pathologies originating from the gastrointestinal tract, with an annual incidence of approximately 13 to 45/100,000. [1] The clinical picture may range from moderate to severe, or even mortal, in some cases. Although the mortality rate is around 1%, it increases with age.…”

Section: Introductionmentioning

confidence: 99%

Significance of Red Blood Cell Distribution Width and CRP/Albumin Levels in Predicting Prognosis of Acute Pancreatitis

Yılmaz

Kandemır²

2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute pancreatitis (AP) is one of the major pathologies among gastrointestinal system diseases. The aim of this study was to determine the relationship between the red cell distribution width (RDW) value and the C-reactive protein (CRP)/ albumin ratio in patients with AP. METHODS: In this retrospective study, AP cases were enrolled and divided into 2 groups according to the Ranson criteria as moderate or severe pancreatitis. The RDW and CRP/albumin values, length of hospitalization and stay in the intensive care unit (ICU), and the complications experienced were compared between these 2 groups. RESULTS: A total of 264 patients were included in the study. Moderate pancreatitis was detected in 204 patients (77.2%) while severe pancreatitis was seen in 60 patients (22.8%) (p=0.081). There was no statistically significant difference in the RDW value between the groups (p=0.193). The CRP/albumin values were significantly higher in the severe pancreatitis group compared with the moderate group (p<0.001). The severe AP group also had a longer period of hospital care, both overall and in the ICU (p=0.001, p=0.047). CONCLUSION: RDW was not a specific marker for predicting prognosis in AP, but the CRP/albumin ratio is an easy-to-apply, inexpensive, and reliable marker.

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Prognostic value of red blood cell distribution width in hepatocellular carcinoma

Cited by 41 publications

References 28 publications

Prognostic value of red cell distribution width (RDW) in colorectal cancer. Results from a single-center cohort on 591 patients

Prognostic value of red cell distribution width (RDW) in colorectal cancer. Results from a single-center cohort on 591 patients

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

Significance of Red Blood Cell Distribution Width and CRP/Albumin Levels in Predicting Prognosis of Acute Pancreatitis

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