Prognostic value of regional lymph node status in canine mammary carcinomas

Szczubiał, Marek; Łopuszyński, Wojciech

doi:10.1111/j.1476-5829.2011.00268.x

Cited by 45 publications

(43 citation statements)

References 28 publications

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“…These findings are in agreement with reports by [28], which note a classical drainage pattern, possessing predetermined drainage sites, such as the lymphosomes. In their study, however, no dye or contrast was used, considering only the topographic correlation between neoplasia and lymph node as a lymphadenectomy parameter.…”

Section: Considerationssupporting

confidence: 83%

Metastasis of Mammary Carcinoma in Bitches: Evaluation of the Sentinel Lymph Node Technique

Beserra¹,

Grandi²,

Düfloth³

et al. 2016

ABCR

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In recent years the development of extremely accurate techniques for the removal of lymph nodes has been seen, such as the Sentinel Lymph Node Biopsy (SLNB) technique. The technique is based on the staggered progression occurring in the lymphatic drainage of neoplasias, and is currently the main prognostic and diagnostic factor in women suffering from mammary carcinoma. This research aims at assessing the sentinel lymph node biopsy accuracy in female dogs suffering from mammary carcinoma. Forty-one dogs with cytological diagnosis of the tumor were used in the research. After injecting a Patent Blue V dye, mastectomy was conducted jointly with lymphadenectomy (for both sentinel and non-sentinel lymph nodes). The material was then serially sectioned and microscopically evaluated by routine H&E stain and immunohistochemical study with the markers for pancytokeratin AE1/AE3 and myoepithelial cells CK14. The study revealed that 46.3% (19/41) of the animals presented nodal metastasis. The sensitivity and specificity values found for SLNB were respectively 89.5% and 100%, with a kappa coefficient of 0.90 and p < 0.0001. Therefore, the SLNB technique offers high sensitivity in the early detection of metastases, allowing higher precision in the staging of oncological patients and, therefore, offering higher chances of survival.

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Section: Considerationssupporting

confidence: 83%

Metastasis of Mammary Carcinoma in Bitches: Evaluation of the Sentinel Lymph Node Technique

Beserra¹,

Grandi²,

Düfloth³

et al. 2016

ABCR

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“…The presence of lymph node macrometastases is also a clinically relevant prognostic factor in dogs with mammary tumors 36. However, a novel finding of similar prognostic relevance was the identification of isolated cells in these animals.…”

Section: Discussionmentioning

confidence: 99%

“…The identification of locoregional lymph node macrometastases from malignant epithelial mammary tumors is essential for determining postsurgical prognosis 36. However, no differences in disease‐free survival and overall survival times between animals without metastasis and animals with lymph node micrometastases were reported in that study 36…”

mentioning

confidence: 90%

Quantitation of the Regional Lymph Node Metastatic Burden and Prognosis in Malignant Mammary Tumors of Dogs

Araújo

Campos

Ferreira

et al. 2015

Veterinary Internal Medicne

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BackgroundAs in women, regional lymph node status impacts survival in dogs with malignant mammary tumors. However, few studies have evaluated regional lymph node metastases in dogs with malignant mammary gland tumors.ObjectivesTo estimate overall survival based on the assessments of the lymph node status and the morphologic and morphometric features in female dogs with malignant mammary gland tumors.Materials and MethodsIn total, 178 lymph nodes from 97 female dogs were assessed and reviewed, and after confirmation by immunohistochemistry (IHC), 161 lymph nodes were selected for analysis of metastases. Animals were considered metastasis‐free (negative lymph nodes) only after IHC analysis for cytokeratin AE1/AE3. The number of positive lymph nodes, the number of metastatic foci, the maximum diameter and the area of metastasis were analyzed, and estimates of overall survival were made.ResultsDogs with metastasis had lower mean survival than those with metastasis‐free regional lymph nodes, showing a direct relationship between the number of affected lymph nodes and shorter survival. However, histologic analysis of the lymph nodes identified lower survival rates in animals with macrometastases and isolated tumor cells, areas of metastasis >20.11 mm², and metastatic diameters >7.32 mm.ConclusionThe identification of ≥1 lymph nodes positive for metastasis and morphometric characterization of lymphatic metastases indicate the prognostic relevance of lymph nodes status in dogs with mammary tumors.

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“…Clinically, FMFAC is characterized by a rapid and massive increase in size of one or multiple mammary glands, which appear swollen and tense (14,20,34,35). The fibroadenomatous change is generally nonpainful, dome-shaped and firm.…”

Section: Praca Oryginalnamentioning

confidence: 99%

Progesterone receptor expression and proliferative activity in relation to histological architecture of feline mammary fibroadenomatous change

Krawczyk

Łopuszyński

Szczubiał

et al. 2017

Medycyna Weterynaryjna

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The aim of the study was to determine the relationship between histological architecture and progesterone receptor expression as well as proliferative activity in feline mammary fibroadenomatous change (FMFAC) in female cats. The investigations were performed on 16 surgically removed FMFAC diagnosed based on their gross and microscopic appearance. The lesions were divided into 2 groups based on the number of epithelium layers: lesions with two or less ductal epithelium layers formed group A and lesions with more than two layers of epithelial cells were assigned to group B. Moreover, in each group the lesions were classified according to the cellularity of stroma into three subgroups (with poor, moderate and abundant cellularity). Immunohistochemical examinations were carried out to detect an expression of progesterone receptors (PRs) and a proliferative activity (based on Ki-67 antigen expression). The PR expression and Ki-67 antigen expression were significantly higher in epithelial cells than in stromal cells; however, the differences in above mentioned markers in ductal epithelium and stromal cells between studied groups were not significant. The results of this study indicate that there is no relationship between histological appearance, PR expression and proliferative activity in FMFAC. Moreover, a high percentage of PR-expressing cells in duct epithelium may explain the regression of enlarged mammary gland after administration of progesterone receptor blockers.

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Prognostic value of regional lymph node status in canine mammary carcinomas

Cited by 45 publications

References 28 publications

Metastasis of Mammary Carcinoma in Bitches: Evaluation of the Sentinel Lymph Node Technique

Metastasis of Mammary Carcinoma in Bitches: Evaluation of the Sentinel Lymph Node Technique

Quantitation of the Regional Lymph Node Metastatic Burden and Prognosis in Malignant Mammary Tumors of Dogs

Progesterone receptor expression and proliferative activity in relation to histological architecture of feline mammary fibroadenomatous change

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