Prognostic value of <scp>COX</scp>‐2, <scp>P</scp>53, and <scp>EZH</scp>‐2 evaluated by quantitative image analysis in premalignant and malignant breast lesions

Nicolopoulou-Stamati, P.; Tsipis, Angelos; Chelidonis, George; Patsouris, Efstratios; Athanassiadou, Pauline; Gonidi, Maria; Athanassiadou, Anna Maria

doi:10.1002/dc.23217

Diagnostic Cytopathology

2014

DOI: 10.1002/dc.23217

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Prognostic value of COX‐2, P53, and EZH‐2 evaluated by quantitative image analysis in premalignant and malignant breast lesions

P. Nicolopoulou-Stamati

Angelos Tsipis

George Chelidonis

et al.

Abstract: Our study showed that the expression of COX-2, EZH-2, and p53 as determined by immunocytochemistry at quantitative level may be a predictor for distinguishing cytologically atypical hyperplastic from malignant breast lesions and may be regarded as potential prognostic factor in breast cancer patients.

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2016

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Predicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program

Zhang

et al. 2016

WJG

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AIMTo determine the association of p53, carcinoembryonic antigen (CEA) and CA19-9 protein expression with esophageal carcinogenesis.METHODSAn iodine staining endoscopic screening program of esophageal lesions was carried out in the high-incidence area of Feicheng County, China. Seventy-seven patients with basal cell hyperplasia (BCH), 247 with low-grade dysplasia (LGD), 51 with high-grade dysplasia (HGD), 134 with invasive cancer, and 80 normal controls diagnosed by mucous membrane biopsy pathology were enrolled. Immunohistochemical detection of p53, CEA and CA19-9 proteins was performed. In the ROC curve analysis, the expression of a single biomarker and the expression of a combination of biomarkers were used to predict the risk of these four esophageal lesions.RESULTSThe positive rates of p53 protein expression in invasive cancer, HGD, LGD, BCH and the normal control groups were 53.0%, 52.9%, 35.6%, 27.3% and 20.0%, respectively; the positive rates of CA19-9 protein expression were 44.0%, 33.3%, 16.5%, 9.2% and 6.2%, respectively; the positive rates of CEA protein expression were 74.6%, 60.8%, 23.3%, 23.7% and 16.2%, respectively. The positive rates of the combined expression of the three biomarkers were 84.3%, 76.5%, 47.6%, 42.9% and 27.5%, respectively. In the receiver operating characteristic curves of the combination of the three biomarkers, the specificity was 88.8% for the normal controls, and the sensitivity was 58.2% for invasive cancer, 25.5% for HGD, 11.2% for LGD, and 6.5% for BCH.CONCLUSIONp53, CEA and CA19-9 protein expression was correlated with esophageal carcinogenesis, and testing for the combination of these biomarkers is useful for identifying high-risk patients with precancerous lesions.

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Predicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program

Zhang

et al. 2016

WJG

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Prognostic value of COX‐2, P53, and EZH‐2 evaluated by quantitative image analysis in premalignant and malignant breast lesions

Cited by 1 publication

References 36 publications

Predicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program

Predicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program

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