Prognostic value of semi-quantitative tumor uptake on Tc-99m sestamibi breast-specific gamma imaging in invasive ductal breast cancer

Yoon, Hai Jeon; Kim, Yemi; Chang, Kyu Tae; Kim, Bom Sahn

doi:10.1007/s12149-015-0977-3

Cited by 10 publications

(6 citation statements)

References 17 publications

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“…However, very few studies have investigated the correlation of TBR with breast cancer subtype (913). Moreover, the method of TBR measurement, histologic type of breast cancer, and size of the tumor were different among previous studies, resulting in discordant results (91113). …”

Section: Introductionmentioning

confidence: 84%

“…Cwikla et al (12) concluded that the use of the TBR index in scintigraphy was correlated with tumor size, axillary lymph node metastasis, tumor grade, and PR status. A recent study using BSGI for patients with invasive breast cancer demonstrated that TBR showed differences in several prognostic factors including tumor size, NG, HG, and the expression profiles of ER/PR and HER2 (1011). In comparison with these studies, our study showed a discrepancy in that TBR did not show a difference according to NG or the expression profiles of ER and HER2.…”

Section: Discussionmentioning

confidence: 99%

“…This discrepancy may have been attributable to the enrolled patient population. The previous study included 168 patients, larger than the sample in our study, and a tumor size below 1 cm was excluded to avoid a partial volume effect (11). In the present study, a tumor size below 1 cm was included to assess the diagnostic power of BSGI regardless of tumor size.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the uptake of MIBI differs according to the tumor biology and histopathologic characteristics of breast cancer. Previous studies have reported that the tumor-to-background ratio (TBR) of BSGI was correlated with some prognostic factors such as tumor size, histologic grade, axillary lymph node metastasis, and expression of estrogen receptor (ER)/progesterone receptor (PR) (910111213). However, very few studies have investigated the correlation of TBR with breast cancer subtype (913).…”

Section: Introductionmentioning

confidence: 99%

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Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer

et al. 2017

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The purpose of this study was to investigate the correlations between tumor-to-background ratio (TBR) obtained from breast-specific gamma imaging (BSGI) and the prognostic factors of breast cancer. Sixty-seven patients with invasive ductal carcinoma who underwent preoperative BSGI were enrolled. The BSGI images were visually scored from 1 to 5 according to a breast imaging reporting and data system (BIRADS). The TBR results obtained from positive BSGI images were compared according to the following prognostic factors: tumor size; axillary lymph node metastasis; nuclear grade (NG); histologic grade (HG); subtype; Ki-67; and the expression profile of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Among 67 images, 60 were classified as a positive finding (sensitivity 89.6%). A higher TBR value was significantly correlated with tumor size ≥ 2 cm (P = 0.001), axillary lymph node metastasis (P = 0.007), high HG (P = 0.029), negative PR status (P = 0.036), and Ki-67 ≥ 14% (P = 0.007). The TBR showed a significant difference between the luminal A and non-luminal A subtypes (P = 0.007). On multivariate analysis, TBR had a high correlation with tumor size ≥ 2 cm, axillary lymph node metastasis, and negative PR status (P = 0.003, 0.048, and 0.030, respectively). A high TBR on BSGI was significantly correlated with poor prognostic factors of breast cancer. Luminal A subtype, a breast cancer subtype with more favorable prognosis, was associated with a low TBR on BSGI.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer

et al. 2017

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“…BSGI provides independent biological information specific to breast cancer (2)(3)(4)(5)(6). benign and malignant breast masses, preoperative evaluation in breast cancer patients, breast cancer screening and early prediction of the response to neoadjuvant chemotherapy (7,8).…”

Section: Introductionmentioning

confidence: 99%

Correlation of Semi-Quantitative Breast-Specific Gamma Imaging Findings with Dynamic Contrast-Enhanced MRI Parameters Assessed by a Computer-Aided Evaluation Program for Breast Cancer

Ahn

Koo

Park

et al. 2018

J Korean Soc Radiol

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Purpose: To investigate whether a correlation exists between the semi-quantitative breast-specific gamma imaging (BSGI) findings and dynamic contrast-enhanced (DCE) MRI parameters assessed by a computer-aided evaluation program. Materials and Methods: Semi-quantitative index of the lesion to non-lesion (L/N) ratio in BSGI and DCE-MRI parameters was assessed by a computer-aided evaluation program, where 47 cases of invasive breast cancer were obtained. Correlations between the L/N ratio and DCE-MRI parameters were assessed by a computer-aided evaluation program. Tumor diameter (cm), angio-volume (cc), degree of initial peak enhancement (%), persistent enhancement proportion (%), and washout enhancement proportion (%) were analysed. The relationships between the L/N ratio and DCE-MRI parameters were evaluated by a univariate and multivariate regression analysis. Results: The mean L/N ratio of the 47 tumors was 3.63 ± 2.19 (range: 1-13.1). The L/N ratio was higher in tumors with larger diameters (p < 0.001), increased angiovolume (p < 0.001), higher degree of initial peak enhancement (p = 0.005) and increased washout enhancement proportion (p = 0.004). In the multivariate regression analysis, angio-volume (cc) and washout enhancement proportion (%) were associated with L/N ratio (p = 0.007 and p = 0.024, respectively). Conclusion: There was a correlation between the semi-quantitative L/N ratio in BSGI and DCE-MRI parameters assessed by a computer-aided evaluation program for breast cancer.

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Usefulness of feature analysis of breast-specific gamma imaging for predicting malignancy

Choi

Park

et al. 2018

Eur Radiol

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Prognostic value of semi-quantitative tumor uptake on Tc-99m sestamibi breast-specific gamma imaging in invasive ductal breast cancer

Abstract: High BSGI uptake measured by a semi-quantitative method was correlated with diverse poor histologic prognostic factors and was an independent poor prognostic factor in invasive ductal cancer.

Cited by 10 publications

References 17 publications

Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer

Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer

Correlation of Semi-Quantitative Breast-Specific Gamma Imaging Findings with Dynamic Contrast-Enhanced MRI Parameters Assessed by a Computer-Aided Evaluation Program for Breast Cancer

Usefulness of feature analysis of breast-specific gamma imaging for predicting malignancy

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