Prognostic value of serological markers of hepatitis B virus infection in squamous cell cervical cancer

Wu, Xinghan; Li, Lan; Li, Yanqing; Jiang, Meiping; Li, Kangming; Li, Zheng; Zhang, Lan

doi:10.7150/jca.61249

Cited by 4 publications

(8 citation statements)

References 35 publications

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“…The association between HPV infection and cervical cancer development has been established, where the evidence demonstrated a high concurrent rate of HBV and HPV co-infection (118, 119). Subsequently, recent hospital-based and epidemiological studies investigated the influence of HBV infection on cervical cancer development and prognosis (8,12,(120)(121)(122). However, the influence of HBV infection on cervical cancer risk is debated.…”

Section: Cervical Cancermentioning

confidence: 99%

“…Therefore, the conclusion for the causal effect between HBV infection and cervical cancer risk requires further evaluation with more comprehensive clinical information. An increasing number of studies revealed that anti-HBs seropositivity and prior HBV infection might be independent favorable prognostic factors for the OS and DFS of patients with cervical cancer (120,121), whereas HBx protein exerted an adverse effect on cervical cancer progression (122). Accordingly, in-depth explorations of the interaction between HBV and HPV in inducing the carcinogenesis of cervical lesions and the immune microenvironment in HPV infection patients with cervical cancer with prior HBV infection could aid understanding of the role of HBV infection status and anti-HBV treatment in cervical cancer risk and future prognosis.…”

Section: Cervical Cancermentioning

confidence: 99%

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Hepatitis B virus infection: An insight into the clinical connection and molecular interaction between hepatitis B virus and host extrahepatic cancer risk

Wei

Xia³

et al. 2023

Front. Immunol.

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The evidence for chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) occurrence is well established. The hepatocyte epithelium carcinogenesis caused by HBV has been investigated and reviewed in depth. Nevertheless, recent findings from preclinical and observational studies suggested that chronic HBV infection is equally important in extrahepatic cancer occurrence and survival, specifically gastrointestinal system-derived cancers. Immune microenvironment changes (immune-suppressive cytokine infiltration), epigenetic modification (N6-methyladenosine), molecular signaling pathways (PI3K–Akt and Wnt), and serum biomarkers such as hepatitis B virus X (HBx) protein are potential underlying mechanisms in chronic HBV infection-induced extrahepatic cancers. This narrative review aimed to comprehensively summarize the most recent advances in evaluating the association between chronic HBV infection and extrahepatic cancer risk and explore the potential underlying molecular mechanisms in the carcinogenesis induction of extrahepatic cancers in chronic HBV conditions.

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Section: Cervical Cancermentioning

confidence: 99%

Section: Cervical Cancermentioning

confidence: 99%

Hepatitis B virus infection: An insight into the clinical connection and molecular interaction between hepatitis B virus and host extrahepatic cancer risk

Wei

Xia³

et al. 2023

Front. Immunol.

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Section: Introductionmentioning

confidence: 99%

“…HBV infection correlates with a poor prognostic outcome in patients with pancreatic cancer, 8 nasopharyngeal carcinoma (NPC), 9 advanced non‐small cell lung cancer (NSCLC), 10 breast cancer, 11 and ovarian cancer 12 . In contrast, HBV infection is reportedly an independent favorable prognostic factor in patients with esophageal cancer who underwent esophagectomy, 13 with no survival influence in patients with squamous cell cervical cancer 14 …”

Section: Introductionmentioning

confidence: 99%

“…12 In contrast, HBV infection is reportedly an independent favorable prognostic factor in patients with esophageal cancer who underwent esophagectomy, 13 with no survival influence in patients with squamous cell cervical cancer. 14 Nevertheless, only a few clinical studies have investigated the outcomes of patients with HNSCC and HBV infection. The impact of HBV infection on the outcome of HNSCC remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Survival outcomes of patients with head and neck squamous cell cancer with hepatitis B virus infection: An analysis from an endemic tertiary center

Lai

Lin

et al. 2022

Cancer Medicine

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Background Hepatitis B virus (HBV) affects the occurrence and survival outcome of various malignant disorders. The study aimed to evaluate the survival outcome of head and neck squamous cell cancer (HNSCC) patients with or without HBV infection. Methods This study included patients with HNSCC who visited Taichung Veterans General Hospital from 2007 to 2015. HBV infection was defined by hepatitis B surface antigen (HBsAg) seropositivity. By propensity score matching, we compared survival outcomes, including progression‐free survival (PFS) and overall survival (OS), among patients with or without HBV infection. Results The prevalence of HBV infection in our cohort was 12.3%. Among the 1,015 patients included in the matched analysis, a higher risk of baseline liver cirrhosis (11.3% vs. 3.4%, p < 0.001) and initial hepatic dysfunction (10.8% vs. 5.4%, p = 0.005) rates were observed than those without HBV infection at baseline. The 5‐year OS was 43.1% and 53.2% ( p < 0.001) and the 5‐year PFS was 37.4% and 42.3% ( p = 0.007) in patients with and without HBV infection, respectively. The incidence of subsequent hepatic dysfunction showed no difference between patients with and without HBV infection (29.6% vs. 26.8%, p = 0.439). Conclusions Patients with HNSCC and HBV infection were younger and had a higher risk of cirrhosis compared to those without HBV infection. Moreover, HBV infection significantly influenced the OS and PFS outcomes but not subsequent hepatic dysfunction in patients with HNSCC.

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Anti-HBV Efficacy of Ficus Plant's Leaf Extract against the Most Dominant HBV Genotypes in the Nile Delta Region of Egypt

et al. 2023

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H EPATITIS B virus (HBV) infects millions of people worldwide annually, causing chronic liver diseases such as cirrhosis, fibrosis, and hepatocellular carcinoma. HBV has nine known genotypes (A, B, C, D, E, F, G, H, and I) and a tentative tenth genotype (J). Identifying HBV genotyping is crucial since different genotypes and sub-genotypes can influence treatment outcomes and responses to antiviral therapy. Therefore, we employed conventional polymerase chain reaction (PCR) to determine the HBV genotypes in three Egyptian governorates: Dakahlia (DK), Gharbia (GHR), and El-Sharkia (SHR). Specific primers for various HBV genotypes (A, B, C, D, E, and F) were used for this purpose. Out of 38 samples, three samples (7.8%) were found to have the D genotype, and four samples (10.5%) were identified as genotype C. The genotypes that were discovered underwent deep sequencing, which revealed two bands in the sequence results that were 99% identical to genotype D. The remaining bands could not be sequenced or gave unclear and incorrect sequence data. We evaluated the leaf extracts of three Ficus species (F. mysorensis, F. deltoidei, and sycomorus) as antiviral substances against HBV infection using an MTT assay. The results showed promising antiviral effects of these extracts, which could potentially aid in stopping the progression of HBV infection. Our findings indicate that conventional PCR with deep sequencing can accurately identify HBV genotypes, and Ficus plants may serve as an excellent supplement to standard treatment for HBV infections.

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Prognostic value of serological markers of hepatitis B virus infection in squamous cell cervical cancer

Cited by 4 publications

References 35 publications

Hepatitis B virus infection: An insight into the clinical connection and molecular interaction between hepatitis B virus and host extrahepatic cancer risk

Hepatitis B virus infection: An insight into the clinical connection and molecular interaction between hepatitis B virus and host extrahepatic cancer risk

Survival outcomes of patients with head and neck squamous cell cancer with hepatitis B virus infection: An analysis from an endemic tertiary center

Anti-HBV Efficacy of Ficus Plant's Leaf Extract against the Most Dominant HBV Genotypes in the Nile Delta Region of Egypt

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