Prognostic Value of Serum Albumin for Long-Term Mortality in Patients with Dual-Chamber Permanent Pacemakers

Hayıroğlu, Mert İlker; Çınar, Tufan; Çinier, Göksel; Yüksel, Gizem; Pay, Levent; Keskin, Kıvanç; Coşkun, Cahit; Ayan, Gökçem; Çiçek, Vedat; Tekkeşin, Ahmet İlker

doi:10.2217/bmm-2021-0991

Cited by 17 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research had established that traditional cardiovascular risk variables such as age, renal dysfunction, male gender, a family history of coronary artery disease, heart failure, and diabetes are predictors of death following Pacemaker implantation (16). Additionally, more research had been conducted on the association between nutritional status and clinical outcomes (17,18). In this study, we examined this association using the changes in PNI and GNRI scores during the follow-up.…”

Section: Discussionmentioning

confidence: 99%

The change in nutritional status is related to cardiovascular events in patients with pacemaker implantation: A 4-year follow-up study

et al. 2022

View full text Add to dashboard Cite

BackgroundThe aim of our study was to evaluate changes in nutritional status as measured by the prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) scores, and their abilities to predict clinical prognosis in patients with pacemaker implantation (PMI).MethodsA total of 595 patients who underwent permanent PMI from January 2011 to December 2020 were included. PNI and GNRI scores were separately calculated at the beginning day of PMI operation and at the end of 12-month follow-up, and their net changes (Δ) were calculated by PNI or GNRI scores at follow-up minus the corresponding scores on admission. The cohort patients were divided into low risk of malnutritional status (ΔPNI or ΔGNRI scores ≥ 0) and high risk of malnutritional status (ΔPNI or ΔGNRI scores < 0) groups. Primary outcome measure was a composite major adverse cardiovascular event (MCE), defined as heart failure hospitalization (HFH), myocardial infarction (MI), stroke, or death from any cause, presented as hazard ratios (HR) with 95% confidence intervals (CI) calculated by MCE in the crude or multivariate-adjusted Cox Proportional Hazards models. Receiver operating characteristic (ROC) curve analysis was used to compare the differential ability to predict incident MCEs betweenΔPNI andΔGNRI scores.ResultsIn total, 16% of patients developed the MCE during the follow-up. The cumulative event rates determined by Kaplan–Meier analysis were significantly higher in the high risk of malnutritional patients compared to the low risk of malnutritional patients (P < 0.05). Adjusted multivariate analysis showed that decreased PNI scores (HR: 2.228, 95% CI: 1.482–3.350) and decreased GNRI scores (HR: 2.178, 95% CI: 1.439–3.295) were independently associated with favorable outcomes. ROC curve analysis revealed an area under curve (AUC) of 0.586 forΔPNI scores and AUC of 0.592 for ΔGNRI scores, but their predictive abilities were not statistically different.ConclusionEither positive change of PNI or GNRI scores were associated with reduced risk of MCEs in patients with PMI, and they have similar ability to predict clinical cardiometabolic risk. Additional enhancing nutritional status during follow-up may help to prevent unfavorable prognosis in clinical practices.

show abstract

Section: Discussionmentioning

confidence: 99%

The change in nutritional status is related to cardiovascular events in patients with pacemaker implantation: A 4-year follow-up study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Prior researches conducted across various populations has demonstrated that serum ALB is a significant independent predictor of long-term mortality in individuals with CVD. 19 , 20 Age is a widely recognized risk factor for long-term mortality in individuals with HF. 21 Elevated TBIL levels at admission are also linked to higher systolic blood pressure and increased risk of cardiac mortality in acute HF patients.…”

Section: Discussionmentioning

confidence: 99%

The Simplified Thrombo-Inflammatory Score as a Novel Predictor of All-Cause Mortality in Patients with Heart Failure: A Retrospective Cohort Study

Cheng,

Zheng,

Zhang

et al. 2024

JIR

View full text Add to dashboard Cite

Background The simplified thrombo-inflammatory score (sTIPS) has recently emerged as a novel prognostic score. Hence, we investigated the prognostic value of sTIPS for predicting long-term mortality in patients with heart failure (HF). Methods A total of 3741 patients were analyzed in this study. The sTIPS was calculated based on the white blood cell count (WBC) and the mean platelet volume to platelet count (MPV/PC) ratio at admission. The mean follow-up time was 22.75 months. Multivariable Cox regression analyses were used to investigate the associations between the sTIPS and all-cause mortality (ACM). Results In the whole study population, multivariate Cox regression analysis showed that patients in both the sTIPS 2 and sTIPS 1 groups had significantly increased risk of ACM as compared with patients in the sTIPS 0 group (hazard ratio [HR]=1.706, 95% confidence interval [CI]: 1.405–2.072, P<0.001 and HR = 1.431, 95% CI 1.270–1.612, P<0.001). The same significant trend was observed in heart failure with preserved ejection fraction (HFpEF) patients (sTIPS1 vs sTIPS0: HR = 1.366, 95% CI 1.100–1.697, P = 0.005; sTIPS2 vs sTIPS0: HR = 1.995, 95% CI 1.460–2.725, P<0.001). However, only sTIPS 1 group had a significantly increased the risk of ACM compared to the sTIPS 0 group among patients with HFmrEF (sTIPS1 vs sTIPS0: HR = 1.648, 95% CI 1.238–2.194, P = 0.001) and HFrEF (sTIPS1 vs sTIPS0: HR = 1.322, 95% CI 1.021–1.712, P = 0.035). Conclusion sTIPS is useful in predicting risk for long-term mortality in patients with HF.

show abstract

“…In the present study, we found that circNFIB had a positive regulatory effect on myocardial fibrosis. Therefore, to some extent, we can expect this factor to be used as a diagnostic and prognostic biomarker of certain cardiovascular diseases in the future, which is also a problem that many researchers have been exploring [ 38 – 40 ]. This topic still requires further in-depth research on different disease models.…”

Section: Discussionmentioning

confidence: 99%

Elucidating the role of circNFIB in myocardial fibrosis alleviation by endogenous sulfur dioxide

Liu

Zhang

Wang

et al. 2022

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background To investigate the role of circNFIB in the alleviation of myocardial fibrosis by endogenous sulfur dioxide (SO2). Methods We stimulated cultured neonatal rat cardiac fibroblasts with transforming growth factor-β1 (TGF-β1) and developed an in vitro myocardial fibrosis model. Lentivirus vectors containing aspartate aminotransferase 1 (AAT1) cDNA were used to overexpress AAT1, and siRNA was used to silence circNFIB. The SO2, collagen, circNFIB, Wnt/β-catenin, and p38 MAPK pathways were examined in each group. Results In the in vitro TGF-β1-induced myocardial fibrosis model, endogenous SO2/AAT1 expression was significantly decreased, and collagen levels in the cell supernatant and type I and III collagen expression, as well as α-SMA expression, were all significantly increased. TGF-β1 also significantly reduced circNFIB expression. AAT1 overexpression significantly reduced myocardial fibrosis while significantly increasing circNFIB expression. Endogenous SO2 alleviated myocardial fibrosis after circNFIB expression was blocked. We discovered that circNFIB plays an important role in the alleviation of myocardial fibrosis by endogenous SO2 by inhibiting the Wnt/β-catenin and p38 MAPK pathways. Conclusion Endogenous SO2 promotes circNFIB expression, which inhibits the Wnt/β-catenin and p38 MAPK signaling pathways, consequently alleviating myocardial fibrosis.

show abstract

Prognostic Value of Serum Albumin for Long-Term Mortality in Patients with Dual-Chamber Permanent Pacemakers

Cited by 17 publications

References 21 publications

The change in nutritional status is related to cardiovascular events in patients with pacemaker implantation: A 4-year follow-up study

The change in nutritional status is related to cardiovascular events in patients with pacemaker implantation: A 4-year follow-up study

The Simplified Thrombo-Inflammatory Score as a Novel Predictor of All-Cause Mortality in Patients with Heart Failure: A Retrospective Cohort Study

Elucidating the role of circNFIB in myocardial fibrosis alleviation by endogenous sulfur dioxide

Contact Info

Product

Resources

About