Prognostic Value of Serum Cholinesterase in Organophosphate Poisoning

Nouira, Semir; Abroug, Fékri; Elatrous, Souheil; Boujdaria, Rafik; Bouchoucha, Slah

doi:10.1378/chest.106.6.1811

Cited by 80 publications

(60 citation statements)

References 19 publications

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“…Noiura S et al concluded that serum cholinesterase levels have no prognostic value in acute OP poisoning. 11 The present study aims to study, and correlate serum cholinesterase level and the clinical criteria score described by the POP scale at initial presentation and the severity of OP poisoning. The correlation may help in predicting the clinical outcome and in making timely decisions regarding transferring the patients for intensive care management.…”

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confidence: 99%

A study on serum cholinesterase level in organophosphorus poisoning and its correlation with severity of organophosphorus poisoning

2018

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Background: There has been a steady increase in the use of organophosphates (OPs) as pesticides in most of the developing countries including India for more than 50 years. OPs tend to be the commonest cause of poisoning worldwide and are persistently and deliberately used in suicides in Agrarian areas. As stated by WHO, 3 million cases of pesticide poisoning occur every year, of these about 1 million are accidental and 2 million are suicidal poisonings, resulting in more than 0.25 million deaths per year. As there is limited availability of facilities and resources in developing countries, all OP poisoning patients are not managed in intensive care units. Hence it is important to understand the clinical features and other factors that indicate severity of poisoning which should be identified in the initial examination.Methods: It was a hospital based prospective study of 100 OP poisoning patients that were attending to casualty of BIMS Hospital and Medical College Belagavi, India. Over a period, patients fulfilling inclusion criteria were included and patients were categorized according to Peradeniya Organophosphorus Poisoning (POP) scale. Serum cholinesterase level measured at the time of admission.Results: The patients were in the age group of 18 to 70 years. Majority of the patients were in the age group of 21-30 years (51%). Sixty nine percent of the patients were from rural areas and 38% of them were farmers. Sixty nine percent of patients were from low socioeconomic stratum. Major route of intake of poison was ingestion. Eighty four percent of patients consumed poison with a suicidal intent. In this study, authors observed that there is a significant correlation between the severity of poisoning categorized by the POP scale and the serum cholinesterase at the time of initial presentation of the patients (P<0.001).Conclusions: Present study concluded that significant correlation between the degree of derangement in serum cholinesterase level and severity of poisoning at the initial presentation. Higher the score on the POP scale, the greater was the degree of derangement in the serum cholinesterase level.

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confidence: 99%

A study on serum cholinesterase level in organophosphorus poisoning and its correlation with severity of organophosphorus poisoning

2018

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“…Organophosphates and carbamates are the predominant types of pesticide used and are of specific concern due to their highly toxic impact on humans and other organisms 3,4) . Exposure to organophosphate and carbamate pesticides is the major cause of cholinesterase depression and plasma cholinesterase has been used as an exposure index, to assess low-level, chronic residue exposures among field workers [5][6][7] . Although agrichemicals are important for food hygiene, by preventing mould damage, flies, and other insects from contaminating food, their potential hazardous effects on humans makes their inappropriate use worrisome 8) .…”

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Serum Cholinesterase Levels of Thai Chilli‐Farm Workers Exposed to Chemical Pesticides: Prevalence Estimates and Associated Factors

Kachaiyaphum

Howteerakul

Sujirarat

et al. 2010

Journal of Occupational Health

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Serum Cholinesterase Levels of Thai Chilli-Farm Workers Exposed to Chemical Pesticides: Prevalence Estimates and AssociatedFactors: Prasit KACHAIYAPHUM, et al. Faculty of Public Health, Mahidol University, Thailand-Objective: To estimate the prevalence of, and factors associated with, abnormal serum cholinesterase (SChE) levels among chilli-farm workers in Chatturat District, Chaiyaphum Province. Methods: A total of 350 chilli-farm workers aged 18-60 yr were randomly sampled and interviewed. A reactive-paper finger-blood test was used to assess SChE levels. Results: The prevalence of abnormal SChE levels was 32.0%. The most common pesticide-related symptoms were dizziness (38.0%), headache (30.9%), nausea/vomiting (26.9%), and fever (26.9%). Multiple logistic regression analysis revealed 7 factors were independently associated with abnormal SChE level: male gender, single/separated/ divorced, being a permanent worker, spraying pesticide more than 3 times per month, having moderate or poor pesticide-use behaviors, and low perceived susceptibility and severity of pesticide use. Conclusions: The prevalence of abnormal SChE levels among chilli-farm workers was quite high. It would be beneficial to decrease pesticide use and encourage alternative measures. Effective preventive interventions to increase correct perceptions of pesticide use, the use of personal protective measures and continuing monitoring for blood cholinesterase, especially for male permanent farm workers, are recommended. (J Occup Health 2010; 52: 89-98)

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“…(10)(11)(12) In most of the studies. (10)(11)(12)(13)(14) incidence of poisoning was common among female, but in our study males were commonly affected. Basic steps involved in the treatment of poisoning are 1.…”

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confidence: 60%

A Case Control Study of Intravenous Magnesium Sulphate in Treatment of Acute Organophosphate Poisoning

Philomena¹,

Sathi²,

Parthasarathy³

2016

jemds

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Prognostic Value of Serum Cholinesterase in Organophosphate Poisoning

Cited by 80 publications

References 19 publications

A study on serum cholinesterase level in organophosphorus poisoning and its correlation with severity of organophosphorus poisoning

A study on serum cholinesterase level in organophosphorus poisoning and its correlation with severity of organophosphorus poisoning

Serum Cholinesterase Levels of Thai Chilli‐Farm Workers Exposed to Chemical Pesticides: Prevalence Estimates and Associated Factors

A Case Control Study of Intravenous Magnesium Sulphate in Treatment of Acute Organophosphate Poisoning

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