2021
DOI: 10.21203/rs.3.rs-458280/v1
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Prognostic Value of Serum MICA Levels as a Marker of Severity in COVID-19 Patients

Abstract: Purpose: The global pandemic of COVID-19 and high mortality rates, necessitate the development of diagnostic and prognostic tools and expansion of testing capacity. The existing approaches to identification and characterization of SARS-COV-II infection are usually based on viral genome detection or measuring COVID-19-specific antibody levels. Despite being valuable, these methods are unable to anticipate disease outcomes in patients. Given the point that the innate immune cells, particularly NK cells, ‌contrib… Show more

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Cited by 3 publications
(2 citation statements)
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“…Indeed, decreased NK cell numbers, impaired cytotoxic activity, and a biased inflammatory phenotype have been reported in SARS-CoV-2 infection, indicating that NK cells likely integrate into the underlying immune dysregulation in COVID-19. In addition, sMICA levels were considerably higher in COVID-19 patients with severe disease (60). In this context, our findings bring additional potential mechanisms involving NK dysfunctions [reviewed by (61)], which could be confirmed by functional assays.…”
Section: Natural Killer Cell Activity Pathwaysupporting
confidence: 66%
“…Indeed, decreased NK cell numbers, impaired cytotoxic activity, and a biased inflammatory phenotype have been reported in SARS-CoV-2 infection, indicating that NK cells likely integrate into the underlying immune dysregulation in COVID-19. In addition, sMICA levels were considerably higher in COVID-19 patients with severe disease (60). In this context, our findings bring additional potential mechanisms involving NK dysfunctions [reviewed by (61)], which could be confirmed by functional assays.…”
Section: Natural Killer Cell Activity Pathwaysupporting
confidence: 66%
“…Cкринінг визнано одним із основних напрямків боротьби із глаукомою. 631 Однак, результати проведених досліджень свідчать про недоцільність масового скринінгу всього населення на глаукому. В той же час скринінг економічно виправданий та необхідний для осіб із груп високого ризику виникнення цього захворювання, що в першу чергу ставить на порядок денний окреслення таких груп, а від того -систематизацію чинників ризику виникнення галукоми.…”
Section: Mini-invasive Surgery For Post-thrombotic Disease Of the Low...unclassified