Prognostic value of serum myoglobin in patients after cardiac surgery

Abstract

Serum myoglobin is associated with outcome in patients after cardiac surgery. Prediction of ICU mortality and need for RRT was comparable for myoglobin and creatinine, while both were significantly superior to CK.

Relation between Serum Pro-Brain Natriuretic Peptide, Myoglobin, CK Levels and Morbidity and Mortality in High Voltage Electrical Injuries

“…Myoglobin, a 17,800 Dalton protein molecule consisting of 153 amino acids, is present only in heart and skeletal muscular tissue (3). Detectable myoglobin in the serum can be derived from either the cardiac muscle or the skeletal muscular system, or both.…”

Associated Factors for Non-Ischemic Serum Myoglobin Release After Cardiac Surgical Procedures

“…This applies in particular to patients with Leukocytes/nL low 7.8 ± 2.9 11.6 ± 5.6 11.1 ± 5.3 11.9 ± 5.8 12.5 ± 6.0 high 6.8 ± 1.5 11.2 ± 3.9 9.7 ± 3.2 10.8 ± 3.9 11.0 ± 3.8 renal failure [Slater 1998]. Hofmann et al also have shown that myoglobin levels were more than 10 times higher in their group of patients who died in the intensive care unit than in the group of survivors [Hofmann 2007]. The postoperative finding of increased myoglobin levels due to muscle injury is prognostic for the occurrence of acute kidney injury and renal replacement therapy [Ramarapu 2011].…”

“…The postoperative finding of increased myoglobin levels due to muscle injury is prognostic for the occurrence of acute kidney injury and renal replacement therapy [Ramarapu 2011]. As a prognostic marker of acute kidney injury, myoglobin provides greater accuracy than creatine kinase (CK) [Huerta-Alardín 2005;Hofmann 2007], among other reasons because there is an earlier increase in the muscle protein than in CK [Janssen 2000]. Perioperative myocardial injury alone, however, cannot entirely explain the occurrence of increased blood myoglobin levels.…”

“…Perioperative myocardial injury alone, however, cannot entirely explain the occurrence of increased blood myoglobin levels. These markers indicate the important role of skeletal muscle disintegration and necrosis in interpreting the origin of such large quantities of muscle protein [Hofmann 2007]. Benedetto et al provided evidence of this in a subanalysis of their study, in which patients with perioperative myocardial injury were excluded and myoglobin concentrations were still increased [Benedetto 2010].…”

“…Increased serum myoglobin levels have been shown to play a major role in the pathogenesis of acute renal failure due to rhabdomyolysis [Huerta-Alardín 2005]. Markedly increased myoglobin levels are associated with a poorer postoperative outcome [Hofmann 2007]. In the diagnosis of ischemia, myoglobin already has a place as a reliable routine parameter in everyday clinical practice.…”