Prognostic value of serum resistin levels in patients with acute myocardial infarction

Erer, Hatice Betül; Sayar, Nurten; Güvenç, Tolga Sinan; Aksaray, Sebahat; Yilmaz, Hale; Altay, Servet; Turer, Ayca; Öz, Tuğba Kemaloğlu; Karadeniz, Fatma Özpamuk; Öz, Dilaver; Ekmekçi, Ahmet; Zencirci, Aycan Esen; Eren, Mehmet

doi:10.5603/kp.a2013.0086

Cited by 15 publications

(13 citation statements)

References 18 publications

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“…Montazerifar et al [17] has found association between high serum leptin levels (another adipokine) and CAD, but there was no significant serum resistin elevation in CAD patients in their study in contrast to previous studies A study by Lee et al showed that high serum resistin levels were dependent predictors for all-cause mortality in patients with AMI [18]. In contrast, Erer et al showed the association of high baseline resistin levels with an increased risk of MACE and resistin was found to be an independent risk factor for predicting MACE in patients with AMI [19]. In a study, systemic review and meta-analysis, Fontana et al analyzed data from Gargano Heart Study (GHS) which was prospective in nature, to investigate the association between resistin and both all cause and cardiovascular (CV) mortality risk [20] [21].…”

Section: U Y Sinan Et Al World Journal Of Cardiovascular Diseasescontrasting

confidence: 54%

The Association between Serum Resistin Levels and Major Adverse Cardiac Events

Sinan¹,

Çetinarslan²,

Oktay³

et al. 2017

WJCD

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Resistin is a member of the family of cysteine-rich secretary proteins called resistin-like molecules (RELMs). It is suggested to be involved in inflammatory conditions and atherosclerosis. We have established a significant correlation between serum resistin levels and coronary artery disease (CAD) in a study was performed between 2011 and 2012 in our institute in two hundred fourteen patients (164 CAD patients and 50 controls). Then the CAD patients were followed up to investigate the relationship between increased serum resistin levels and major adverse cardiac events (MACE) between 2012 and 2016. One hundred fifty-five of 164 patients (95%) were followed up and 9 patients lost to follow up. There were 39 MACE (25%) in four years of follow-up. There were 16 in-hospital deaths due to cardiac causes, 8 revascularization procedures, and 15 re-hospitalization due to acute coronary syndrome (ACS) or heart failure (HF). The patients with MACE had similar serum resistin level (median: 71.37 pg/ml) compared to patients without MACE (median: 80.23 pg/ml) (p > 0.05).

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Section: U Y Sinan Et Al World Journal Of Cardiovascular Diseasescontrasting

confidence: 54%

The Association between Serum Resistin Levels and Major Adverse Cardiac Events

Sinan¹,

Çetinarslan²,

Oktay³

et al. 2017

WJCD

View full text Add to dashboard Cite

show abstract

“…The association of resistin with heart failure persisted after adjustment for established heart failure risk factors, obesity, markers of insulin resistance and inflammation, and concentrations of NT-proBNP, and after exclusion of prevalent and incident CHD. Erer et al 33 concluded that serum resistin concentration was elevated in patients with acute STEMI (sustained ST segment elevation of myocardial infarction), and this increase was more obvious in patients with T2DM than in those without diabetes.…”

Section: Discussionmentioning

confidence: 99%

Role of resistin, IL-6 and NH2-terminal portion proBNP in the pathogenesis of cardiac disease in type 2 diabetes mellitus

Ghanem¹,

Abdel‐Samiee

Torky

et al. 2020

BMJ Open Diab Res Care

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IntroductionEpidemiological and genetic studies have recorded the association between proinflammatory cytokines and the development of insulin resistance, diabetes, and cardiovascular disease. The role of interleukin 6 (IL-6), NH2-terminal portion pro-brain natriuretic peptide (NT-proBNP) and resistin in the pathogenesis of heart disease in type 2 diabetes mellitus (T2DM) is still a matter of controversy. The current study aimed to evaluate the role of these biomarkers in the development of left ventricular systolic dysfunction and the ability to use them as non-invasive test in the prediction of left ventricular hypertrophy and systolic dysfunction in T2DM.Research design and methods150 participants were included in this case–control study. Patients were divided into two subgroups according to echocardiographic findings: group 1a included 46 patients with type 2 diabetes mellitus and echocardiographic evidence of abnormal systolic function; group 1b included 54 patients with type 2 diabetes mellitus and with normal echocardiogenic study; and group 2 included 50 apparently healthy controls. Routine laboratory investigations such as complete blood count, liver and renal function tests, and lipid profile, serum IL-6, NT-proBNP, and resistin were measured in all participants. Conventional echocardiography was done with special concern on the assessment of left ventricular systolic function (ejection fraction).ResultsThere was a significant increase in the level of resistin, NT-proBNP and IL-6 in group 1a patients compared with group 1b and in healthy controls. Echocardiographic parameters showed a significant increase in left ventricular mass index, left ventricle posterior wall thickness, interventricular septum thickness, and left ventricle mass in group 1a compared with group 1b and the control group. The increased left ventricular mass index was associated with higher levels of IL-6, NT-proBNP and resistin.ConclusionsProinflammatory cytokines had a clear relation with left ventricular systolic dysfunction and hypertrophy and can be used as early non-invasive markers for detection of left ventricular remodeling and systolic dysfunction in patients with T2DM.

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“…In addition, Erer HB [ 8 ] reported that serum resistin levels were similar in patients with STEMI and NSTEMI. Canga et al [ 32 ] demonstrated a significant increase of serum resistin levels in patients with slow coronary flow compared to patients with normal coronary flow.…”

Section: Discussionmentioning

confidence: 99%

Increased serum resistin level is associated with coronary heart disease

et al. 2017

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To explore the relationship between the serum resistin level and different types of coronary heart diseases (CHD). Literature was retrieved by formal searching of PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, China Biological Medicine Database (SinoMed) and China National Knowledge Infrastructure (CNKI) and by hand searching of reference lists of related articles. RevMan5.3 statistical software was utilized for processing and analysis. A total of 22 literatures involving 2070 subjects were included. Meta-analysis showed that the level of serum resistin in the patients with stable angina (SA), unstable angina(UA) or acute myocardial infarction (AMI) were significantly higher than those of normal controls, respectively [SMD(95% CI) were 1.97(1.15, 2.79), 2.54(1.76, 3.31), and 3.62(2.62, 4.62), all P<0.00001]. Serum resistin level in patients with UA or AMI was higher than those in patients with SA, respectively [SMD=0.90, 95CI(0.28,1.52), P=0.005], [SMD=2.28, 95%CI(0.74, 3.82), P=0.004]. The level of serum resistin in patients with AMI was also higher than those in patients with UA [SMD=1.22, 95%CI(0.58, 1.85), P=0.0002]. The study demonstrated that increased serum resistin level is significantly associated with the severity of CHD.

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Prognostic value of serum resistin levels in patients with acute myocardial infarction

Abstract: Serum resistin level was increased in patients with AMI and constituted a risk factor for MACE in this group.

Cited by 15 publications

References 18 publications

The Association between Serum Resistin Levels and Major Adverse Cardiac Events

The Association between Serum Resistin Levels and Major Adverse Cardiac Events

Role of resistin, IL-6 and NH2-terminal portion proBNP in the pathogenesis of cardiac disease in type 2 diabetes mellitus

Increased serum resistin level is associated with coronary heart disease

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