Prognostic Value of Serum Tumor Markers in Patients with Lung Cancer

Hatzakis, Kostas; Froudarakis, Marios; Bouros, Demosthenes; Tzanakis, Νikolaos; Karkavitsas, Nikolaos; Siafakas, Nikolaos M.

doi:10.1159/000049366

Cited by 85 publications

(60 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…29 Elevated NSE and CYFRA 21-1 levels are associated with poor outcome. 30 The treatment options for neuroendocrine tumors are surgical resection of tumor mass and/or therapy with cytotoxic drugs, inhibitors of angiogenesis, somatostatin analogs and receptor targeted radiotherapy. 31 Surgical therapy is the treatment of choice when it is applicable.…”

Section: Discussionmentioning

confidence: 99%

Ectopic calcitonin secretion in a woman with large cell neuroendocrine lung carcinoma

Cvijović¹,

Micić²,

Kendereški³

et al. 2013

View full text Add to dashboard Cite

ObJEctIVE: serum calcitonin (ct) is a sensitive but not specific marker for medullary thyroid carcinoma (Mtc). there are a large number of conditions that may elevate ct levels. cAsE rEPOrt: Herein we present the case of a 47-year old woman with Hashimoto thyroiditis, goiter, cervical lymphadenopathy and high ct and cEA levels. After surgical extirpation of the lymph node neuroendocrine cancer metastasis was suspected. computed tomography of the chest showed a tumor mass on the right lung. bronchoscopy was performed and pathological and immunohistochemical analysis revealed large cell neuroendocrine lung cancer (LcNEc). After chemotherapy, significant reduction of tumor mass was achieved with a moderate decrease in ct levels in parallel. cONcLUsIONs: We present a female with LcNEc, a condition which is usually observed in older men (7 th decade) and is not associated with ct secretion. Hashimoto thyroiditis is associated with increased incidence of different types of cancers (e.g. thyroid, colon). No reports at present exist on the incidence of lung cancers in patients with thyroid disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Ectopic calcitonin secretion in a woman with large cell neuroendocrine lung carcinoma

Cvijović¹,

Micić²,

Kendereški³

et al. 2013

View full text Add to dashboard Cite

show abstract

“…However, NSE could not be included in our analyses, as in our institution it is used infrequently and only for diagnostic purposes (Hatzakis et al, 2002). Future research should assess if adjusting for NSE may affect the results of flexible analyses of NSCLC mortality.…”

Section: Discussionmentioning

confidence: 99%

Flexible modeling improves assessment of prognostic value of C-reactive protein in advanced non-small cell lung cancer

et al. 2010

View full text Add to dashboard Cite

BACKGROUND: C-reactive protein (CRP) is gaining credibility as a prognostic factor in different cancers. Cox's proportional hazard (PH) model is usually used to assess prognostic factors. However, this model imposes a priori assumptions, which are rarely tested, that (1) the hazard ratio associated with each prognostic factor remains constant across the follow-up (PH assumption) and (2) the relationship between a continuous predictor and the logarithm of the mortality hazard is linear (linearity assumption). METHODS: We tested these two assumptions of the Cox's PH model for CRP, using a flexible statistical model, while adjusting for other known prognostic factors, in a cohort of 269 patients newly diagnosed with non-small cell lung cancer (NSCLC). RESULTS: In the Cox's PH model, high CRP increased the risk of death (HR ¼ 1.11 per each doubling of CRP value, 95% CI: 1.03 -1.20, P ¼ 0.008). However, both the PH assumption (P ¼ 0.033) and the linearity assumption (P ¼ 0.015) were rejected for CRP, measured at the initiation of chemotherapy, which kept its prognostic value for approximately 18 months. CONCLUSION: Our analysis shows that flexible modeling provides new insights regarding the value of CRP as a prognostic factor in NSCLC and that Cox's PH model underestimates early risks associated with high CRP.

show abstract

“…Another study has indicated that the sensitivity and specificity of CA-125 in diagnosing early ovarian cancer are 72 and 95%, respectively (41). Apart from ovarian tumors, CA-125 has also been confirmed to have a high positive detection ratio in lung cancer patients (11). CA-125 is expressed in ~51% of lung cancer tissues, and the level is closely correlated with the differentiated degree of tumors (42).…”

Section: Sensitivity % (N) -----------------------------------------mentioning

confidence: 98%

“…Studies have focused on carcinoembryonic antigen (CEA) for over 40 years (6), suggesting it be a useful tool in the diagnosis of cancer (7), as it is a cancer cell adhesion marker (8,9). The neuron-specific enolase (NSE) is a highly specific marker for neurons (10), with its serum level being a potentially useful marker for the detection of tumors of neuronal origin (11,12). Cytokeratin 19 (CYFRA21-1) is another useful tumor marker employed in the diagnosis of various types of cancer (13)(14)(15), and is particularly sensitive in adenocarcinomas in the gastrointestinal tract and pancreas (13,16 (2,17).…”

Section: Introductionmentioning

confidence: 99%

Combining multiple serum biomarkers in tumor diagnosis: A clinical assessment

Lü

Ren

et al. 2012

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. The present study aimed to assess the diagnostic/ prognostic value of various clinical tumor markers, including carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 (CYFRA21-1), α-fetoprotein (AFP), carbohydrate antigen-125 (CA-125), carbohydrate antigen-19.9 (CA-19.9) and ferritin, individually or in combination. The electro-chemiluminescence immunization method was performed to detect the levels of seven tumor markers in 560 cancer patients and 103 healthy subjects for comparison. The serum levels of the seven markers measured in cancer patients were higher compared to healthy subjects (P<0.05 for AFP and P<0.001 for the remaining six markers). Different markers had different sensitivity towards different types of tumors. Combining more markers significantly increased the ratios of positive diagnosis in the tumors. The diagnostic sensitivities of combining seven markers were particularly high in digestive, urinary and skeletal tumors (82, 92 and 83%, respectively). Gynecological tumors have exhibited a constant yet relatively low positive diagnosis irrespective of the use of a single marker or combined markers. However, the increase in sensitivity when combining markers was accompanied by a decrease in specificity. Generally, combining more markers increased the tumor detection rates, while a combination of the seven markers provided the highest detection rate. Combined detection showed a particularly high sensitivity in detecting respiratory, digestive and urinary system tumors, with the lowest sensitivity observed in gynecological tumors. As a result, combining tumor markers may play an important role in early tumor detection/diagnosis while the loss of specificity can be tolerated.

show abstract

Prognostic Value of Serum Tumor Markers in Patients with Lung Cancer

Cited by 85 publications

References 22 publications

Ectopic calcitonin secretion in a woman with large cell neuroendocrine lung carcinoma

Ectopic calcitonin secretion in a woman with large cell neuroendocrine lung carcinoma

Flexible modeling improves assessment of prognostic value of C-reactive protein in advanced non-small cell lung cancer

Combining multiple serum biomarkers in tumor diagnosis: A clinical assessment

Contact Info

Product

Resources

About