Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

Kim, Yong Il; Cheon, Gi Jeong; Kang, Seo Young; Paeng, Jin Chul; Kang, Keon Wook; Lee, Dong Hoon; Chung, June Key

doi:10.1186/s13550-018-0357-9

Cited by 22 publications

(33 citation statements)

References 35 publications

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“…In every case, the following combined PET/ADC parameters were calculated according to previous descriptions [17] , [19] : SUV max divided by ADC min (SUV max /ADC min ), SUV max divided by ADC men (SUV max /ADC mean ), TLG divided by ADC min (TLG/ADC min ), TLG divided by ADC mean (TLG/ADC min ), MTV divided by ADC min (SUV max /ADC min ), MTV divided by ADC mean (SUV max /ADC mean ). …”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, some authors suggested that several 18 F-FDG-PET, DWI and DCE MRI parameters can be combined together [17] , [18] , [19] . For example, Baba et al calculated a new parameter, namely SUV/ADC, and showed that it had a great potential in differentiation between malignant and benign breast lesions [17] .…”

Section: Introductionmentioning

confidence: 99%

“…For example, Baba et al calculated a new parameter, namely SUV/ADC, and showed that it had a great potential in differentiation between malignant and benign breast lesions [17] . According to Kim et al, combined parameters of 18 F-FDG-PET/MRI could be effective predictors of tumor treatment failure after head and neck cancer surgery [19] . Presumably, combined parameters from 18 F-FDG-PET and MRI may increase the diagnostic potential of the imaging and may be better associated with clinically relevant biological parameters in HNSCC than DWI, DCE-MRI and 18 F-FDG-PET parameters alone.…”

Section: Introductionmentioning

confidence: 99%

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Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study

Surov

Meyer

Höhn

et al. 2019

Translational Oncology

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BACKGROUND: Our purpose was to evaluate associations of combined 18F-FDG-PET and MRI parameters with histopathological features in head and neck squamous cell carcinoma (HNSCC). METHODS: Overall, 22 patients with HNSCC were acquired (10 with G1/2 tumors and 12 with G3 tumors).18F-FDG-PET/CT and MRI was performed and maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) were estimated. Neck MRI was obtained on a 3 T scanner. Diffusion weighted imaging was performed with estimation of apparent diffusion coefficient (ADC). Perfusion parameters Ktrans,Ve, and Kep were derived from dynamic contrast-enhanced (DCE) imaging. Different combined PET/MRI parameters were calculated as ratios: PET parameters divided by ADC or DCE MRI parameters. The following histopathological features were estimated: Ki 67, EGFR, VEGF, p53, hypoxia-inducible factor (HIF)-1α, and cell count. Spearman's correlation coefficient (p) was used for correlation analysis. P < .05 was taken to indicate statistical significance. RESULTS: In overall sample, cellularity correlated with SUVmax/ADCmin (P = .558, P = .007), TLG/ADCmin (P = .546, P = .009), and MTV/ADCmin (P = .468, P = .028). MTV/Kep correlated with expression of HIF-1α (P = .450, P = 0,047). In G1/2 tumors, SUVmax/ADCmin correlated with HIF-1α (P = −.648, P = .043); MTV/Kep (P = −.669, P = .034) and TLG/Kep (P = −.644, P = .044) with Ki67. In G3 tumors, cellularity correlated with SUVmax/ADCmin (P = .832, P = .001), SUVmax/ADCmean (P = .741, P = .006), and TLG/ADCmin (P = .678, P = .015). MTV/ADCmin and TLG/ADCmin tended to correlate with HIF-1α. CONCLUSION: Combined parameters of 18F-FDG-PET and MRI can reflect Ki 67, tumor cellularity and expression of HIF-1α in HNSCC. Associations between parameters of 18F-FDG-PET and MRI and histopathology depend on tumor grading.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study

Surov

Meyer

Höhn

et al. 2019

Translational Oncology

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“…Limited data on the combination of imaging techniques was published. Kim et al [46] found that volumetric MATV, TLG corrected by tumor cellularity (ADC min and ADC mean ) and were prognostic for LR [46]. However, their patient population underwent surgery, and sub-optimal delineation of only one imaging technique was performed.…”

Section: Tablementioning

confidence: 99%

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Martens

Noij

Zwezerijnen

et al. 2019

European Journal of Radiology

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Background and purpose: In head and neck squamous cell carcinoma (HNSCC) (chemo)radiotherapy is increasingly used to preserve organ functionality. The purpose of this study was to identify predictive pretreatment DWI-and 18 F-FDG-PET/CT-parameters for treatment failure (TF), locoregional recurrence (LR) and death in HNSCC patients treated by (chemo)radiotherapy. Materials and methods: We retrospectively included 134 histologically proven HNSCC patients treated with (chemo)radiotherapy between 2012-2017. In 58 patients pre-treatment DWI and 18 F-FDG-PET/CT were performed, in 31 patients DWI only and in 45 patients 18 F-FDG-PET/CT only. Primary tumor (PT) and largest lymph node (LN) metastasis were quantitatively assessed for TF, LR and death. Multivariate analysis was performed for 18 F-FDG-PET/CT and DWI separately and thereafter combined. In patients with both imaging modalities, positive and negative predictive value in TF and differences in LR and death, were assessed. Results: Mean follow-up was 25.6 months (interquartile-range; 14.0-37.1 months). Predictors of treatment failure, corrected for TNM-stage and HPV-status, were SUV max-PT , ADC max-PT , total lesion glycolysis (TLG-LN), ADCp20-LN (P = 0.049, P = 0.024, P = 0.031, P = 0.047, respectively). TLG-PT was predictive for LR (P = 0.003). Metabolic active tumor volume (MATV-PT) (P = 0.003), ADC GTV-PT (P < 0.001), ADCSD (P = 0.048) were significant predictors for death. In patients with both imaging modalities SUV max-PT remained predictive for treatment failure (P = 0.049), TLG-LN for LR (P = 0.003) and ADC GTV-PT for death (P < 0.001). Higher predictive value for treatment failure was found for the combination of SUV max-PT and ADC max-PT , compared to either one separately. Conclusion: Both DWI-and 18 F-FDG-PET/CT-parameters appear to have predictive value for treatment failure, locoregional recurrence and death. Combining SUV max-PT and ADC max-PT resulted in better prediction of treatment failure compared to single parameter assessment.

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“…There is a limited number of studies on the relationship between PET imaging and HPV status in HNSCC [3,[15][16][17]. Furthermore, very few studies concern the utility of PET/MRI in the characterization of HPV-related HNC [8,18]. According to our knowledge, there are no literature reports documenting the correlation between Epstein-Barr virus (EBV) status and PET/MRI features.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Hybrid PET/MRI in Clinical Evaluation of Head and Neck Cancer Patients

Samołyk-Kogaczewska¹,

Sierko

Dziemiańczyk-Pakieła

et al. 2020

Cancers

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(1) Background: The novel hybrid of positron emission tomography/magnetic resonance (PET/MR) examination has been introduced to clinical practice. The aim of our study was to evaluate PET/MR usefulness in preoperative staging of head and neck cancer (HNC) patients (pts); (2) Methods: Thirty eight pts underwent both computed tomography (CT) and PET/MR examination, of whom 21 pts underwent surgical treatment as first-line therapy and were further included in the present study. Postsurgical tissue material was subjected to routine histopathological (HP) examination with additional evaluation of p16, human papillomavirus (HPV), Epstein-Barr virus (EBV) and Ki67 status. Agreement of clinical and pathological T staging, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of CT and PET/MR in metastatic lymph nodes detection were defined. The verification of dependences between standardized uptake value (SUV value), tumor geometrical parameters, number of metastatic lymph nodes in PET/MR and CT, biochemical parameters, Ki67 index, p16, HPV and EBV status was made with statistical analysis of obtained results; (3) Results: PET/MR is characterized by better agreement in T staging, higher specificity, sensitivity, PPV and NPV of lymph nodes evaluation than CT imaging. Significant correlations were observed between SUVmax and maximal tumor diameter from PET/MR, between SUVmean and CT tumor volume, PET/MR tumor volume, maximal tumor diameter assessed in PET/MR. Other correlations were weak and insignificant; (4) Conclusions: Hybrid PET/MR imaging is useful in preoperative staging of HNC. Further studies are needed.

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Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

Cited by 22 publications

References 35 publications

Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study

Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Usefulness of Hybrid PET/MRI in Clinical Evaluation of Head and Neck Cancer Patients

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