Prognostic Value of Systemic Immune-Inflammation Index and NT-proBNP in Patients with Acute ST-Elevation Myocardial Infarction

Zhu, Yinghua; He, Haibo; Qiu, Hang; Shen, Guoqi; Wang, Zhen; Li, Wenhua

doi:10.2147/cia.s397614

Cited by 12 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have highlighted the importance of inflammation in AMI in both human and animals. 33 , 34 , 35 , 36 Hypoalbuminaemia is a known marker of inflammation. 37 In the present study, patients with LVA exhibited lower level of ALB than those without LVA, suggesting that inflammation may play a crucial role in this association.…”

Section: Discussionmentioning

confidence: 99%

Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction

Zhang,

Yang,

et al. 2024

ESC Heart Failure

View full text Add to dashboard Cite

AimsLeft ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. The aim of this study was to investigate the possible predictive value of blood urea nitrogen‐to‐albumin ratio (BAR) for the LVA formation in acute ST‐segment elevation myocardial infarction (STEMI) patients who underwent primary percutaneous coronary intervention (PCI).Methods and resultsA total of 1123 consecutive patients with STEMI were prospectively enrolled. The clinical and laboratory data were compared between LVA group and non‐LVA group. Multivariable logistic regression analysis was performed to assess the independent risk factors of LVA formation. Predictive power of BAR and composite variable for LVA formation were assessed using receiver operating characteristic curve. LVA was detected in 162 patients (14.4%). The BAR was significantly higher in patients with LVA [0.16 (0.13–0.19) vs. 0.13 (0.10–0.17), P < 0.001]. Multivariable logistic regression analysis revealed that left ventricular ejection fraction (LVEF) [odds ratio (OR) = 0.865, P < 0.001], culprit vessel–left anterior descending artery (LAD) (OR = 4.705, P < 0.001), and BAR (OR = 2.208, P = 0.018) were all independent predictors for LVA formation. The predictive value of BAR remained significant even after cross‐validation by splitting population into training set (OR = 1.957, P = 0.034) and validation set (OR = 1.982, P = 0.039). The maximal length and width of LVA were significantly increased in patients with BAR ≥ 0.15 when compared with BAR < 0.15 (3.37 ± 1.09 vs. 2.92 ± 0.93, P = 0.01, for maximal length, and 2.20 ± 0.55 vs. 1.85 ± 0.63, P = 0.001, for maximal width). The discriminant power of BAR for LVA is 0.723, which is superior to both blood urea nitrogen (C statistic = 0.586, P < 0.001) and albumin (C statistic = 0.64, P < 0.001). The combination of BAR, LVEF, and culprit vessel–LAD could significantly increase the predictive ability (C statistic = 0.874, P < 0.001, for vs. BAR). Subgroup analysis of age, sex, hypertension, diabetes, smoking, LVEF, serum albumin, multiple‐vessel disease, and Gensini score had no effect on the association between BAR and risk of LVA formation (P < 0.05 for all subgroups).ConclusionsA higher BAR was an independent predictor for LVA formation in STEMI patients with primary PCI.

show abstract

Section: Discussionmentioning

confidence: 99%

Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction

Zhang,

Yang,

et al. 2024

ESC Heart Failure

View full text Add to dashboard Cite

show abstract

“…Its prohormone, the N-terminal fragment of the brain-type natriuretic peptide (NT-proBNP), has been found to be correlated to SII [ 40 ]. Moreover, SII and NT-proBNP represented independent determinants of clinical prognosis in acute STEMI patients when considering a composite endpoint (including all-cause mortality, re-hospitalization, nonfatal myocardial infarction, acute heart failure, and non-fatal stroke), and they were positively correlated [ 41 ]. Thus, confounding variables (e.g., creatinine and BNP levels) may alter the association of inflammatory parameters with the outcome in question and should always be considered in the statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction

Marchi,

Pylypiv,

Parlanti

et al. 2024

JCM

View full text Add to dashboard Cite

(1) Background: The systemic inflammatory response index (SIRI; neutrophil count × monocyte/lymphocyte count), and the systemic immune-inflammation index (SII; platelet count × neutrophil count/lymphocyte count) are recently proposed biomarkers to assess the immune and inflammatory status. However, data on SIRI and SII are still relatively lacking and do not definitively and exhaustively define their role as predictors of an adverse prognosis in acute myocardial infarction (AMI). The aim of the present study was to evaluate SII and SIRI determinants as well as to assess SIRI and SII prognostic power in ST-elevation myocardial infarction (STEMI). (2) Methods: A total of 105 STEMI patients (74 males, 70 ± 11 years) were studied (median follow-up 54 ± 25 months, 24 deaths). (3) Results: The main determinants of SIRI and SII were creatinine and brain natriuretic peptide (BNP) (multivariate regression). Patients with higher SIRI (>75th percentile, 4.9) and SII (>75th percentile, 1257.5) had lower survival rates than those in the low SIRI/SII group (Kaplan–Meier analysis). Univariate Cox regression revealed that high SIRI and SII were associated with mortality (HR: 2.6, 95% CI: 1.1–5.8, p < 0.05; 2.2, 1–4.9, p ≤ 0.05, respectively); however, these associations lost their significance after multivariate adjustment. (4) Conclusions: SIRI and SII association with mortality was significantly affected by confounding factors in our population, especially creatinine and BNP, which are associated with both the inflammatory indices and the outcome.

show abstract

“…The study investigated the association between SII and system inflammation response index (SIRI) with all-cause mortality and cardiovascular mortality in America over a 20-year follow-up period [27]. Zhu Y-confirmed that SII was an independent indicator of clinical prognosis in acute ST-elevation myocardial infarction (STEMI) patients [28]. The Dongfeng-Tongji cohort study in Chinese suggested SII may serve as a useful marker to elucidate the role of the interaction of thrombocytosis, inflammation and immunity in the development of stroke and coronary heart disease (CHD) in the middle-aged and elderly [29].…”

Section: Plos Onementioning

confidence: 94%

The relationship between a series of inflammatory markers on the risk of heart failure in different gender groups: Analysis from NHANES 2015–2018

Cheng,

Yu,

Qiu

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background A better understanding of the level-grade inflammation for the development and worsening of heart failure (HF) in different gender groups is an unmet need. We performed an updated analysis on the impact of a series of systemic inflammation markers on HF. Methods This compensatory cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (NHANES) 2015–2018. HF was based on the self-reported questions. Univariate and multivariate logistic regression were used to investigate the association between systemic immune-inflammation index (SII), high sensitivity C-reactive protein (hs-CRP), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and HF. For patients of different genders, P for trend was used to analyze potential linear trend relationships and the restricted cubic splines (RCS) were used to describe non-linear relationships. The additive interaction was evaluated by the relative excess risk due to interaction (RERI), attributable proportion (AP), and the synergy index (SI). The multiplicative interaction was evaluated by odds ratio (OR) and 95% confidence interval (CI) of product-term. Results A total of 5,830 participants from the NHANES database were divided into two groups: the HF group (n = 210) and the non-HF group (n = 5620). After gender stratification, hs-CRP (OR: 1.01, 95% CI: 1.00–1.03), SII (OR: 1.00, 95% CI: 1.00–1.01), NLR (OR: 1.22, 95% CI: 1.11–1.35) and LMR (OR: 0.79, 95% CI: 0.65–0.93) were independent meaningful factors for HF in males, there was no non-linear relationship between the three factors (SII, NLR, hs-CRP, all P for non-linear > 0.05) and the prevalence of HF, but we detected a non-linear relationship between LMR and the prevalence of HF in males (P for non-linear < 0.05). An additive interaction of hs-CRP and NLR on the risk of HF in males (RERI (OR): 0.67, 95% CI: 0.12–1.34; AP (OR): 0.14, 95% CI: 0.02–0.24; SI (OR): 1.22, 95% CI: 1.03–1.44). Conclusions In summary, hs-CRP, NLR, and LMR are superior meaningful markers for HF in males. SII may be a meaningful systemic inflammation warning marker for HF, which needs to be discriminated against with caution. Only detected a non-linear relationship between LMR and the prevalence of HF in males. NLR and hs-CRP may have an additive interaction in the prevalence of male HF patients. The outcome compensated for previous studies that still needed more studies for validation.

show abstract

Prognostic Value of Systemic Immune-Inflammation Index and NT-proBNP in Patients with Acute ST-Elevation Myocardial Infarction

Cited by 12 publications

References 31 publications

Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction

Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction

Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction

The relationship between a series of inflammatory markers on the risk of heart failure in different gender groups: Analysis from NHANES 2015–2018

Contact Info

Product

Resources

About