Prognostic Value of Systemic Inflammatory Indices, NLR, PLR, and MPV, for Predicting 1-Year Survival of Patients Undergoing Cytoreductive Surgery with HIPEC

Kim, Na Young; Chun, Duk-Hee; Baik, Seung Hyuk; Hong, Jung Hwa; Kim, Kyung Sub; Shin, Cheung Soo

doi:10.3390/jcm8050589

Cited by 30 publications

(27 citation statements)

References 37 publications

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“…Recent literature has shown that some components of the routine complete blood cell (CBC) count, such as white blood cell count (WBC), hemoglobin, neutrophil count, lymphocyte count, platelet count, red cell distribution width (RDW), mean platelet volume (MPV), and some of their ratios, such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), can aid in the diagnosis of malignancies, cardiovascular disease, autoimmune diseases, and some pregnancy pathologies [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Association Between Complete Blood Count Components and Intrahepatic Cholestasis of Pregnancy

Silva

Magenta

Sisti

et al. 2020

Cureus

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Some components of the routine complete blood count (CBC) and their ratios, such as neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been found to be sensitive biomarkers of preeclampsia and other inflammatory obstetric conditions. We wanted to evaluate whether they can be associated with intrahepatic cholestasis of pregnancy (ICP). Materials and MethodsWe conducted a retrospective case-control study between May 1, 2015 and July 1, 2018. Cases were considered pregnancies with ICP and control healthy pregnancies. Cases and controls were matched for age, parity, and race.We compared the levels of white blood cells (WBC), hemoglobin, neutrophils, lymphocytes, NLR, PLR, platelets, red cell distribution width (RDW), and mean platelet volume (MPV) in the first and third trimesters between cases and controls. In addition, we compared the same components in the third trimester between patients with mild (serum total bile acid (TBA) of 10 -40 µmols/L) and severe (TBA > 40 µmols/L) ICP. ResultsThere were 33 patients with ICP and 33 controls. There were no significant differences between the two groups in the first trimester. WBC, neutrophil count, and NLR were decreased in women with ICP in the third trimester compared to controls. MPV was significantly higher in the third trimester of patients with ICP compared to controls. RDW was lower in mild ICP compared to severe ICP in the third trimester. ConclusionDecreased WBC, neutrophil, NLR, and MPV values are associated with ICP and may be useful additions to the diagnostic algorithm for ICP. Larger studies are needed to assess the responsible underlying molecular pathogenic mechanisms.Categories: Obstetrics/Gynecology Keywords: complete blood count, intrahepatic cholestasis of pregnancy, mean platelet volume, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio Open Access Original Article

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Section: Introductionmentioning

confidence: 99%

Association Between Complete Blood Count Components and Intrahepatic Cholestasis of Pregnancy

Silva

Magenta

Sisti

et al. 2020

Cureus

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“…[ 19 , 20 ] This suggests that the peripheral blood immune responses can be used as prognostic factors for acute brain injuries. NLR, PLR, and MPV are known to be associated with inflammation, [ 9 , 11 , 21 ] and NLR has been investigated as a prognostic factor for TBI and other neurosurgical emergencies. [ 3 , 16 , 22 ] Therefore, we investigated the association between hematologic parameters, including inflammatory indices, and mortality among EDH or SDH patients undergoing emergency surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Posttraumatic neuroinflammation is a secondary injury after trauma that causes neurodegeneration and neurological impairment. [ 4 – 8 ] The associations between poor prognoses in various types of cancer and inflammatory mediators have been well documented [ 9 – 11 ] ; additionally, acute TBIs and inflammation are known to be associated. [ 12 – 14 ] Recent studies have suggested that increased levels of inflammatory markers are the predictors of worse outcomes in acute neurosurgical emergencies, such as TBI, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH).…”

Section: Introductionmentioning

confidence: 99%

Hematological factors predicting mortality in patients with traumatic epidural or subdural hematoma undergoing emergency surgical evacuation

Kim

Lim²,

Lee

et al. 2020

Medicine

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Hematological abnormalities at admission are common after traumatic brain injuries and are associated with poor outcomes. The objective of this study was to identify the predictive factors of mortality among patients who underwent emergency surgery for the evacuation of epidural hematoma (EDH) or subdural hematoma (SDH). This was a single-center retrospective cohort study of 200 patients who underwent emergency surgical evacuation of EDH or SDH between September 2010 and December 2018. Data on hematological parameters and clinical and intraoperative features were collected. The primary end-point was 1-year mortality after surgery. Univariate and multivariate analysis were performed, and the receiver operating characteristic (ROC) curves were assessed. Of the 200 patients included in this study, 102 (51%) patients died within 1 year of emergency surgery. Lymphocyte count at admission, creatinine levels, activated partial thromboplastin time (aPTT), age, intraoperative epinephrine use, and Glasgow Coma Scale (GCS) score were significantly associated with mortality in the multivariate analysis. The areas under the ROC curve for the GCS score, aPTT, and lymphocyte counts were 0.677 (95% confidence interval [CI] 0.602–0.753), 0.644 (95% CI 0.567–0.721), and 0.576 (95% CI 0.496–0.656), respectively. Patients with elevated lymphocyte counts on admission showed a higher rate of 1-year mortality following emergency craniectomy for EDH or SDH. In addition, prolonged aPTT and a lower GCS score were also related to poor survival.

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“…Серед інших показників важливо відмітити що крім PLR та NLR, які у більшості випадків підтвердженої інфекції Sars CoV-2 більш тонким показником виявився показник індексу системної реакції запалення (SIRI = відношення нейтрофілів x моноцитів / лімфоцитів) [8,14]. При надходженні даний показник самостійно прогнозує внутрішньолікарняну смертність у пацієнтів з COVID-19 і може допомогти ранньої стратифікації ризику у цій групі [17].…”

Section: результатиunclassified

Hematological parameters of peripheral blood as prognostic factors in patients with COVID-19 (Literature review)

Lysenko¹,

Andrushko²,

Gunko³

2021

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Changes in the complete blood count (CBC) that were recorded in patients against the background of coronavirus infection (COVID-19) attracted the attention of many researchers from the beginning of the pandemic, especially in terms of assessing the prognosis, the severity of the course of the disease in a particular patient. It should be noted that changes in the CBC can be both reactive and systemic response or even reflect the toxic effects of this infection on bone marrow hematopoiesis. The article analyzes the current data in the world literature on changes in CBC against the background of COVID-19 infection to assess their value in the future prognostic sign. To assess the prognosis of the course of the COVID-19 infectious process, a number of peripheral blood indicators were stuck: platelet count, platelet-leukocyte index or systemic inflammation index (ratio of neutrophils × platelets × monocytes to lymphocytes), traditional NLR indices (neutrophil / lymphocyte ratio), PLR (ratio thrombocytopenia / lymphocyte), which with different predictive values indicate the presence of SARS CoV-2 infection, the severity of the course, and the likelihood of a fatal leak or recovery. From the early stages of the disease, COVID-19 is associated with morphological and functional changes in blood cells that are easily detected by conventional haematology analysers, but generalization of the data requires further profiling and multicentre studies. To date, there are no generalized studies on changes in CBC in patients with COVID-19 in the Ukrainian population, which does not allow us to draw conclusions about the features of these changes in this group of patients. It is promising to further study the parameters of peripheral blood in patients with COVID-19 in the Ukrainian population in order to assess reference and prognostic signs and subsequent implementation into practical medical practice.

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Prognostic Value of Systemic Inflammatory Indices, NLR, PLR, and MPV, for Predicting 1-Year Survival of Patients Undergoing Cytoreductive Surgery with HIPEC

Cited by 30 publications

References 37 publications

Association Between Complete Blood Count Components and Intrahepatic Cholestasis of Pregnancy

Association Between Complete Blood Count Components and Intrahepatic Cholestasis of Pregnancy

Hematological factors predicting mortality in patients with traumatic epidural or subdural hematoma undergoing emergency surgical evacuation

Hematological parameters of peripheral blood as prognostic factors in patients with COVID-19 (Literature review)

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