Prognostic value of systemic inflammatory response markers in cervical cancer

SERDAR, Sevgi; Akar, Serra; Kar, İrem; Turan, Ahmet Taner; Türkmen, Osman; Kılıç, Fatih; Aytekın, Okan; Ersak, Burak; Ceylan, Özgün; Tekın, Özlem Moraloğlu; Cömert, Günsu Kimyon

doi:10.1080/01443615.2022.2069482

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Excessive or persistent systemic inflammation, represented by the ratio of circulating blood cell counts, plays a significant role in cancer development and progression. 19 Calculated using peripheral neutrophil, lymphocyte, and platelet counts, SII has been demonstrated to be a powerful prognostic factor for various human malignancies. 20 Cumulative evidence has indicated a significant association between the SII and survival in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Association of body composition and systemic inflammation for patients with locally advanced cervical cancer following concurrent chemoradiotherapy

Li,

Niu,

Zhang

et al. 2024

dir

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PURPOSE Systemic inflammation and body composition are associated with survival outcomes of cancer patients. This study aimed to examine the combined prognostic value of systemic inflammatory markers and body composition parameters in patients with locally advanced cervical cancer (LACC). METHODS Patients who underwent concurrent chemoradiotherapy (CCRT) for LACC at a tertiary referral teaching hospital between January 2010 and January 2018 were enrolled. A predictive model was established based on systemic immune-inflammation index (SII) and computer tomography-derived visceral fat-to-muscle ratio (vFMR). Overall survival (OS) and progression-free survival (PFS) were assessed using the Kaplan–Meier method and Cox regression models. The model performance was assessed using discrimination, calibration, and clinical usefulness. RESULTS In total, 212 patients were enrolled. The SII and vFMR were closely related, and both independently predicted survival (P < 0.05). A predictive model was established based on the above biomarkers and included three subgroups: high-risk [both high SII (>828) and high vFMR (>1.1)], middle-risk (either high SII or high vFMR), and low-risk (neither high SII nor high vFMR). The 3-year OS (PFS) rates for low-, middle-, and high-risk patients were 90.5% (86.0%), 73.9% (58.4%), and 46.8% (36.1%), respectively (P < 0.05). This model demonstrated satisfactory predictive accuracy (area under the curve values for predicting 3-year OS and PFS were 0.704 and 0.718, respectively), good fit (Hosmer–Lemeshow tests: P > 0.05), and clinical usefulness. CONCLUSION Systemic inflammatory markers combined with body composition parameters could independently predict the prognosis of patients with LACC, highlighting the utilization of commonly collected indicators in decision-making processes. CLINICAL SIGNIFICANCE The SII and vFMR, as well as their composite indices, were promising prognostic factors in patients with LACC who received definitive CCRT. Future studies are needed to explore novel therapies to improve the outcomes in high-risk patients.

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Section: Discussionmentioning

confidence: 99%

Association of body composition and systemic inflammation for patients with locally advanced cervical cancer following concurrent chemoradiotherapy

Li,

Niu,

Zhang

et al. 2024

dir

View full text Add to dashboard Cite

show abstract

“…Excessive or persistent systemic inflammatory response, which was accurately reflected by ratios of blood parameters, played an important role in cancer progression. 20 SII based on peripheral lymphocyte, neutrophil and platelet counts has been considered a better prognostic value in various cancers. 4,21 Previous meta-analysis indicated that SII was not associated with statistically improved OS in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Body Composition and Systemic Inflammatory Markers in Patients with Locally Advanced Cervical Cancer Following Chemoradiotherapy

Guo,

Feng,

et al. 2023

JIR

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Background: Abnormal changes in body composition and systemic inflammation response have been associated with poor survival of cancer patients. Our study was to explore the prognostic value of the association between body composition indicators and systemic inflammation markers among patients with locally advanced cervical cancer (LACC) who underwent concurrent chemoradiotherapy (CCRT). Methods: We retrospectively reviewed medical records of LACC patients treated between 2016 and 2019. Subcutaneous, visceral and intra-muscular adipose index (SAI, VAI and IMAI) and skeletal muscle index (SMI) were derived from computed tomography (CT). Kaplan-Meier analysis and Univariate and multivariate Cox analyses were used to evaluate the survival. A nomogram was constructed to assess the prognostic value. Results:The study included 196 patients treated with CCRT. According to multivariable Cox analyses, IIIC1r (P = 0.045), high systemic immune-inflammation index (SII) (P = 0.004), sarcopenia (P = 0.008), high SAI (P = 0.016) and high VAI (P = 0.001) were significantly risk factors for overall survival (OS). Kaplan-Meier analysis showed that patients with low lymphocyte-to-monocyte ratio (LMR) and sarcopenia had longer OS than those with high LMR and sarcopenia (P = 0.023). The high neutrophil-to-lymphocyte ratio (NLR) in non-sarcopenic patients showed better survival (P = 0.022). Low VAI (P = 0.019) or low IMAI (P = 0.019) combined with low SII had a favorable OS. Low LMR combined with low SAI was associated with longer OS (P = 0.022). The calibration plots of nomogram predicting the 3-year and 5-year OS rates were close to the ideal models. Conclusion: Inflammation factors were closely associated with abnormal muscle and fat distribution. The combined prognostic value of body composition indicators and systemic inflammation markers was reliable in predicting survival for LACC patients.

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“…The NLR is superior to the PLR in predicting the gastric cancer survival rate. Ayhan et al ( 99 ) found that a high NLR and PLR was significantly correlated with tumor volume (>2 cm) and deep muscle interstitial infiltration. A high monocyte-to-lymphocyte ratio was significantly correlated with abdominal aortic LNM, pelvic LNM, and locally advanced CC (IB3-IIIC2).…”

Section: Role Of the Tumor Microenvironment In The Lymphatic Metastas...mentioning

confidence: 99%

Role of the tumor microenvironment in the lymphatic metastasis of cervical cancer (Review)

Wang,

Yi,

Teng

et al. 2023

Exp Ther Med

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Lymphatic metastasis is the primary type of cervical cancer metastasis and is associated with an extremely poor prognosis in patients. The tumor microenvironment primarily includes cancer-associated fibroblasts, tumor-associated macrophages, myeloid-derived suppressor cells, immune and inflammatory cells, and blood and lymphatic vascular networks, which can promote the establishment of lymphatic metastatic sites within immunosuppressive microenvironments or promote lymphatic metastasis by stimulating lymphangiogenesis and epithelial-mesenchymal transformation. As the most important feature of the tumor microenvironment, hypoxia plays an essential role in lymph node metastasis. In this review, the known mechanisms of hypoxia, and the involvement of stromal components and immune inflammatory cells in the tumor microenvironment of lymphatic metastasis of cervical cancer are discussed. Additionally, a summary of the clinical trials targeting the tumor microenvironment for the treatment of cervical cancer is provided, emphasizing the potential and challenges of immunotherapy.

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Prognostic value of systemic inflammatory response markers in cervical cancer

Cited by 5 publications

References 41 publications

Association of body composition and systemic inflammation for patients with locally advanced cervical cancer following concurrent chemoradiotherapy

Association of body composition and systemic inflammation for patients with locally advanced cervical cancer following concurrent chemoradiotherapy

Prognostic Value of Body Composition and Systemic Inflammatory Markers in Patients with Locally Advanced Cervical Cancer Following Chemoradiotherapy

Role of the tumor microenvironment in the lymphatic metastasis of cervical cancer (Review)

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