Prognostic value of telomere length in acute coronary syndrome

Rivera, Jaime A.; Pabón-Osuna, Pedro; Cieza-Borrella, Clara; Martín-Herrero, Francisco; Gonzalez-Porras, Jose-Ramon; González‐Sarmiento, Rogelio

doi:10.1016/j.mad.2012.09.003

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…Current evidence supports the idea that telomere length is associated with a number of chronic conditions including dyslipidemia [ 5 ], hypertension [ 6 , 7 ], atherosclerosis [ 8 , 9 ], stroke [ 10 ], coronary artery disease [ 11 , 12 ], myocardial infarction [ 13 ], and poor cardiovascular disease prognosis [ 10 , 14 , 15 ]. Decreased leukocyte telomere length is also present in patients with colorectal [ 16 , 17 ] and ovarian cancers [ 18 ].…”

Section: Introductionmentioning

confidence: 76%

Physical activity and telomere length: Impact of aging and potential mechanisms of action

et al. 2017

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Telomeres protect the integrity of information-carrying DNA by serving as caps on the terminal portions of chromosomes. Telomere length decreases with aging, and this contributes to cell senescence. Recent evidence supports that telomere length of leukocytes and skeletal muscle cells may be positively associated with healthy living and inversely correlated with the risk of several age-related diseases, including cancer, cardiovascular disease, obesity, diabetes, chronic pain, and stress. In observational studies, higher levels of physical activity or exercise are related to longer telomere lengths in various populations, and athletes tend to have longer telomere lengths than non-athletes. This relationship is particularly evident in older individuals, suggesting a role of physical activity in combating the typical age-induced decrements in telomere length. To date, a small number of exercise interventions have been executed to examine the potential influence of chronic exercise on telomere length, but these studies have not fully established such relationship. Several potential mechanisms through which physical activity or exercise could affect telomere length are discussed, including changes in telomerase activity, oxidative stress, inflammation, and decreased skeletal muscle satellite cell content. Future research is needed to mechanistically examine the effects of various modalities of exercise on telomere length in middle-aged and older adults, as well as in specific clinical populations.

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Section: Introductionmentioning

confidence: 76%

Physical activity and telomere length: Impact of aging and potential mechanisms of action

et al. 2017

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“…So far only two prospective studies have been published. In both studies telomere length was an independent predictor of MI and stroke [62,63].…”

Section: Telomeres and Age-associated Diseasesmentioning

confidence: 83%

The role of telomeres and vitamin D in cellular aging and age-related diseases

Pusceddu

Farrell²,

Pierro

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Aging is a complex biological process characterized by a progressive decline of organ functions leading to an increased risk of age-associated diseases and death. Decades of intensive research have identified a range of molecular and biochemical pathways contributing to aging. However, many aspects regarding the regulation and interplay of these pathways are insufficiently understood. Telomere dysfunction and genomic instability appear to be of critical importance for aging at a cellular level. For example, age-related diseases and premature aging syndromes are frequently associated with telomere shortening. Telomeres are repetitive nucleotide sequences that together with the associated sheltrin complex protect the ends of chromosomes and maintain genomic stability. Recent studies suggest that micronutrients, such as vitamin D, folate and vitamin B12, are involved in telomere biology and cellular aging. In particular, vitamin D is important for a range of vital cellular processes including cellular differentiation, proliferation and apoptosis. As a result of the multiple functions of vitamin D it has been speculated that vitamin D might play a role in telomere biology and genomic stability. Here we review existing knowledge about the link between telomere biology and cellular aging with a focus on the role of vitamin D. We searched the literature up to November 2014 for human studies, animal models and in vitro experiments that addressed this topic.

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“…Telomere shortening has been associated with ageing and senescence, and shorter leucocyte telomeres are associated with increased cardiovascular risk and mortality. 45 Shorter leucocyte telomere length predicted high-risk plaque morphology on virtual histology intravascular ultrasound (VH-IVUS). 46 Whether shorter telomere length is a predictor of adverse events among older patients undergoing PCI is not known and will be evaluated in this study.…”

Section: Functional Status and Quality-of-life Measuresmentioning

confidence: 99%

Study to Improve Cardiovascular Outcomes in high-risk older patieNts (ICON1) with acute coronary syndrome: study design and protocol of a prospective observational study

et al. 2016

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Introduction The ICON1 study (a study to Improve Cardiovascular Outcomes in high-risk older patieNts with acute coronary syndrome) is a prospective observational study of older patients (≥75 years old) with non-ST-elevation acute coronary syndrome managed by contemporary treatment (pharmacological and invasive). The aim of the study was to determine the predictors of poor cardiovascular outcomes in this age group and to generate a risk prediction tool. Methods and analysis Participants are recruited from 2 tertiary hospitals in the UK. Baseline evaluation includes frailty, comorbidity, cognition and quality-of-life measures, inflammatory status assessed by a biomarker panel, including microRNAs, senescence assessed by telomere length and telomerase activity, cardiovascular status assessed by arterial stiffness, endothelial function, carotid intima media thickness and left ventricular systolic and diastolic function, and coronary plaque assessed by virtual histology intravascular ultrasound and optical coherence tomography. The patients are followed-up at 30 days and at 1 year for primary outcome measures of death, myocardial infarction, stroke, unplanned revascularisation, bleeding and rehospitalisation. Ethics and dissemination The study has been approved by the regional ethics committee (REC 12/NE/016). Findings of the study will be presented in scientific sessions and will be published in peer-reviewed journals. Trial registration number NCT01933581 : Pre-results.

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Prognostic value of telomere length in acute coronary syndrome

Cited by 8 publications

References 15 publications

Physical activity and telomere length: Impact of aging and potential mechanisms of action

Physical activity and telomere length: Impact of aging and potential mechanisms of action

The role of telomeres and vitamin D in cellular aging and age-related diseases

Study to Improve Cardiovascular Outcomes in high-risk older patieNts (ICON1) with acute coronary syndrome: study design and protocol of a prospective observational study

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