Prognostic value of the ALBI grade among patients with single hepatocellular carcinoma without macrovascular invasion

Abstract

Background: Although evidence for the application of albumin–bilirubin (ALBI) grading system to assess liver function in hepatocellular carcinoma (HCC) is available, less is known whether it can be applied to determine the prognosis of single HCC with different tumor sizes. This study aimed to address this gap.Methods: Here, we enrolled patients who underwent hepatectomy due to single HCC from the year 2010 to 2014. Analyses were performed to test the potential of ALBI grading system to monitor the long-term survival of single HCC subjects with varying tumor sizes.Results: Overall, 265 participants were recruited. The overall survival (OS) among patients whose tumors were ≤ 7 cm was remarkably higher compared to those whose tumors were > 7 cm. The Cox proportional hazards regression model identified the tumor differentiation grade, ALBI grade, and maximum tumor size as key determinants of the OS. The ALBI grade could stratify the patients who had a single tumor ≤ 7 cm into two distinct groups with different prognoses. The OS between ALBI grades 1 and 2 was comparable for patients who had a single tumor > 7 cm.Conclusions: We show that ALBI grading system can predict disease outcomes of single HCC patients with tumor size ≤ 7 cm. However, the ALBI grade may not predict capability the prognosis of patients with single tumor > 7 cm.

The roles of RNA N6-methyladenosine in esophageal cancer

“…Gene transcription abnormalities associated with esophageal cancer, including chromosomal and tumour cell mutations, were a major research focus in the past [ 9 ]. Studies have shown that gene mutation is an important mechanism of esophageal cancer, and various genetic mutations are found in patients with esophageal cancer.…”

Avaliação do Escore Plaqueta-Albumina (PAL) como preditor de risco e sobrevida pós-operatória em pacientes com carcinoma hepatocelular submetidos a ressecção hepática

“…Isso se deve ao adequado manejo pré-operatório, com discussão multidisciplinar de todos os casos com indicação cirúrgica, e programação do procedimento a ser realizado de forma individualizada, evitando ressecções maiores em pacientes com maior risco de PHLF e considerando sempre a possibilidade de preservação de parênquima, especialmente em lesões de até 2 cm. Outros estudos também apontam que a presença de hipertensão portal (109) e de volumes residuais hepáticos menores que 20% a 25% se correlacionam com PHLF (110,111) .…”