2021
DOI: 10.7150/jca.49242
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Prognostic Value of the Albumin-to-γ-glutamyltransferase Ratio for Gallbladder Cancer Patients and Establishing a Nomogram for Overall Survival

Abstract: The albumin-to-γ-glutamyltransferase ratio (AGR), a novel inflammation-related index, has been reported to have prognostic importance in several malignancies but not yet in gallbladder cancer (GBC). This study intended to assess the prognostic value of AGR in GBC and to develop a nomogram based on AGR for predicting overall survival (OS) in GBC patients after surgery. Methods: Medical records of 140 qualified GBC patients between July 2003 and June 2017 were retrospectively analyzed. The function "surv_cutpoin… Show more

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Cited by 13 publications
(5 citation statements)
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“…A good prediction ability was demonstrated by the C-index of our model of 0.803 in the training set and 0.774 in the testing set, which could effectively promote the clinical application of FAR. Sun et al 14 established a nomogram model that considered AGR, T stage, surgical margin, body mass index, and CA19-9 with the C-index of 0.780 and 0.762 in the training and testing set, respectively. Liu et al 8 analyzed 1072 cases from China Gallbladder Cancer Research Group (CRGGC) and established a nomogram prediction model based on SII, T stage, N stage, CA19-9, and surgical margins with the C-index of 0.735 and 0.686 in the training and testing set, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…A good prediction ability was demonstrated by the C-index of our model of 0.803 in the training set and 0.774 in the testing set, which could effectively promote the clinical application of FAR. Sun et al 14 established a nomogram model that considered AGR, T stage, surgical margin, body mass index, and CA19-9 with the C-index of 0.780 and 0.762 in the training and testing set, respectively. Liu et al 8 analyzed 1072 cases from China Gallbladder Cancer Research Group (CRGGC) and established a nomogram prediction model based on SII, T stage, N stage, CA19-9, and surgical margins with the C-index of 0.735 and 0.686 in the training and testing set, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…Because it only takes the conditions of the primary tumor, lymph nodes, and metastasis into consideration and lacks a personal examination reference for individual patients. According to a recent study, a nomogram prediction model based on the albumin-γ-glutamyl transferase ratio outperformed the TNM staging system [ 34 ]. Unfortunately, the Nevin staging system was not included in the study.…”
Section: Discussionmentioning
confidence: 99%
“…surv_cutpoint function was used for identifying the best threshold point (cutoff=-0.9884624) [ 45 ] to divide the samples into a high and low m6A score, performing correlation analysis and survival estimation.…”
Section: Methodsmentioning
confidence: 99%