Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction

Yamamoto, Takashi; Oki, Takashi; Yamada, Hirotsugu; Tanaka, Hideji; Ishimoto, Takuya; Wakatsuki, Tetsuzo; Tabata, Tomotsugu; Ito, Susumu

doi:10.1016/s0894-7317(02)74537-9

Cited by 106 publications

(78 citation statements)

References 35 publications

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“…[30][31][32] As pulmonary capillary wedge pressure is a prognostic indicator in patients with HF, E/e' value is a similarly powerful predictor of prognosis in patients with various cardiac diseases. 33 In the present study, plasma HCII activity was independently and inversely associated with the value of E/e' , suggesting that HCII preserves compliance of the left ventricular wall. Warfarin is a synthetic thrombin inhibitor and is frequently used for the prevention of cardiogenic thrombosis.…”

Section: Discussionsupporting

confidence: 61%

Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors

et al. 2010

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Thrombin has a crucial role in cardiac remodeling through protease-activated receptor-1 activation in cardiac fibroblasts and cardiomyocytes. As heparin cofactor II (HCII) inhibits the action of tissue thrombin in the cardiovascular system, it is possible that HCII counteracts the development of cardiac remodeling. We investigated the relationships between plasma HCII activity and surrogate markers of cardiac geometry, including left atrial volume index (LAVI), relative wall thickness (RWT) and left ventricular mass index, and deceleration time (DcT) and the ratio of peak E velocity to early diastolic mitral annulus velocity (E/e' ratio) as surrogate markers of left ventricular diastolic dysfunction measured using echocardiography in 304 Japanese elderly individuals without systolic heart failure (169 men and 135 women; mean age: 65.4±11.8 years). Mean plasma HCII activity in all participants was 95.8±17.0% and there was no difference between the mean plasma HCII activities in males and females. Multiple regression analysis revealed that there were significant inverse relationships between plasma HCII activity and LAVI (coefficient: À0.2302, Po0.001), between HCII activity and RWT (coefficient: À0.0007, Po0.05), between HCII activity and DcT (coefficient: À0.5189, Po0.05) and between HCII activity and E/e' ratio (coefficient: À0.0558, Po0.01). Plasma HCII activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction. These findings suggest that cardiac tissue thrombin inactivation by HCII is a novel therapeutic target for cardiac remodeling and atherosclerosis.

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Section: Discussionsupporting

confidence: 61%

Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors

et al. 2010

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“…While there is an age related increase in A’ velocity in healthy subjects 97 , the converse is observed with atrial dysfunction where A’ velocity is reduced. Although not as extensively studied as S' and E', A' provides prognostic information and an A' = 5 cm/s in HF patients independently predicted worse prognosis with increased cardiac mortality or HF hospitalisation 98 . A’ also predicts cardiac events and mortality in hypertension 32 .…”

Section: A’ Velocitymentioning

confidence: 99%

“…E/E' > 15 is a powerful prognosticator of adverse cardiac events 104 and is an independent predictor of cardiac mortality and HF hospitalisation in patients with systolic dysfunction 98 . Post myocardial infarction (MI), E/E’ is a powerful predictor of survival and E/E’ > 15 is superior as predictor of prognosis to other clinical or echocardiographic variables 107 .…”

Section: E/e' and T E‐e'mentioning

confidence: 99%

Echocardiographic evaluation of diastolic heart failure

Thomas

2010

Australas J Ultrason Med

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“…Sohn et al [88] performed Valsalva's maneuver in patients with a restrictive transmitral flow velocity pattern, and found that the transmitral flow velocity did not change in patients with whom the peak Aw of the mitral annulus velocity was ≤ 5 cm/s. Therefore, Aw of the mitral annulus is an important predictor of prognosis in patients with LV systolic dysfunction [89]. The prognosis is poorer in patients with a mitral annulus Aw <4 to 5 cm/sec [87][88][89].…”

Section: Figmentioning

confidence: 99%

The Role of Tissue Doppler Imaging as a New Diagnostic Option in Evaluating Left Ventricular Function

Oki

2003

J Echocardiogr

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In general, pump function and myocardial contractility should be assessed when evaluating left ventricular (LV) systolic function. Ejection fraction obtained from left ventriculography is routinely used as an index of pump function, and the maximum value of the first derivative of LV pressure curve (peak dP/dt) has been used as an index of myocardial contractility. On the other hand, active relaxation of the LV myocardium during early diastole and LV passive filling or compliance during mid-to late diastole are important factors in evaluating LV diastolic function. To obtain this information, the time constant of the LV pressure decay during isovolumic diastole (tau) and LV end-diastolic pressure, which are calculated from the LV pressure curve recorded during cardiac catheterization, is used. However, invasive hemodynamic measurements cannot be performed in all patients, nor are they appropriate for follow-up evaluation involving repeated examinations.Recently, routine echocardiography has facilitated the noninvasive evaluation of LV systolic and diastolic function. The percent fractional shortening of the LV based on M-mode echocardiography and the LV ejection fraction determined by two-dimensional echocardiography are indices of LV pump function, and therefore cannot accurately evaluate LV myocardial contractility. On the other hand, "diastology" has become an important clinical topic [1]. There are several reasons why assessment of diastolic function is important: 1) 30 to 40% of patients evaluated for congestive heart failure have normal LV pump function [2,3]; 2) the transmitral flow velocity pattern, which is recorded using the pulsed Doppler method, may be an index for noninvasive evaluation of LV diastolic function [4]; and 3) the prognosis is poor in patients with LV systolic dysfunction and pseudonormalization or restrictive pattern of the transmitral flow velocity [5,6]. However, it has been shown that the diastolic indices obtained from transmitral and pulmonary venous flow velocities are influenced by loading conditions, especially by the pre- The Role of Tissue Doppler Imaging as a New Diagnostic Option in Evaluating Left AbstractThe widespread use of the pulsed Doppler echocardiography has facilitated the noninvasive evaluation of hemodynamic abnormalities of the left atrium and left ventricle (LV) based on transmitral and pulmonary venous flow velocity patterns. However, it has been shown that loading conditions, especially preload, influence the indices obtained from these velocity patterns. Recently, tissue Doppler imaging (TDI) has been applied to the clinical setting to assess LV myocardial function. In particular, this procedure has the following characteristics: 1) it can provide circumferential and longitudinal information for the LV myocardium; 2) the early diastolic LV myocardial parameters determined by TDI are not influenced by preload; 3) LV myocardial contractility can be evaluated from the early systolic parameters; 4) LV systolic and diastolic asynchrony can be detected; 5) myoca...

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Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction

Cited by 106 publications

References 35 publications

Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors

Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors

Echocardiographic evaluation of diastolic heart failure

The Role of Tissue Doppler Imaging as a New Diagnostic Option in Evaluating Left Ventricular Function

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