Prognostic value of the five-repetition sit-to-stand test for mortality in people with chronic obstructive pulmonary disease

Medina-Mirapeix, Françesc; Valera-Novella, Elisa; Morera-Balaguer, Jaume; Bernabeu-Mora, Roberto

doi:10.1016/j.rehab.2021.101598

Cited by 14 publications

(8 citation statements)

References 30 publications

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Section: Discussionmentioning

confidence: 82%

“… 12 , 23 As for 30sCST, our result is consistent with a study showing that 60sCST predicts mortality, 16 and with a study assessing the association between mortality and the time used to perform 5 risings at CST. 24 However, to our best knowledge, no previous study has reported an association between mortality and the 30sCST. We find it clinically important that this very short, feasible, and easy-to-use version of CST could still identify patients with a higher mortality risk.…”

Section: Discussionmentioning

confidence: 87%

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Six-Minute Walking Test and 30 Seconds Chair-Stand-Test as Predictors of Mortality in COPD – A Cohort Study

Höglund¹,

Boström²,

Sundh³

2022

COPD

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Background Physical inactivity is strongly associated with worse prognosis in Chronic Obstructive Pulmonary Disease (COPD), and assessment of physical function is very important. The six minute walking test (6MWT) is an established test known to predict mortality in COPD, and 30 seconds chair stand test (30sCST) is a potential alternative test. The study aimed to investigate and compare the associations of 6MWT and 30sCSTs with mortality. Methods Data on patient demographics, established mortality predictors and results from 6MWT and 30sCST were collected from 2016 to 2019 from 97 consecutively included patients with COPD. In August 2021, mortality data were retrieved from patient records. Correlation analysis of 6MWT and 30sCST was performed. The predictive abilities of 6MWT and 30sCST, respectively, were analyzed using Kaplan Meyer-curves and Cox regression with adjustment for sex, age, body mass index below 22 and comorbid cardiovascular disease. Results A positive correlation between 6MWT and 30sCST was shown (r = 0.61, p < 0.0001). Independent associations with mortality were found for 6MWD 250–349 (HR (95% CI) 3.19 (1.12 to 9.10), p = 0.030) and 6MWD <250 (4.27 (1.69 to10.8), p = 0.002) compared with 6MWD ≥350 meters, and for 30sCST <4 (3.31 (1.03 to 10.6), p = 0.045) compared with 30sCST≥11 risings. When both 6MWT and 30sCST were included in the multivariable model, 6MWD 250–349 (3.09 (1.02 to 9.37), p = 0.046) and 6MWD <250 (3.57 (1.26 to 10.1), p = 0.016) compared with 6MWD ≥350 meters predicted mortality. Conclusion 30sCST and 6MWT correlates moderately and are independently associated with mortality in patients with COPD. Although 6MWT is the best predictor of mortality, 30sCST may be used as an alternative to identify patients at risk.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 87%

Six-Minute Walking Test and 30 Seconds Chair-Stand-Test as Predictors of Mortality in COPD – A Cohort Study

Höglund¹,

Boström²,

Sundh³

2022

COPD

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“…In addition, prospective data suggest, that an increase in gait speed on an individual level predicts increased survival, strengthening the preventative role of physical function [ 52 ]. Also, better performance in the sit-to-stand test has been independently associated with better physical function and increased survival [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries

et al. 2022

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Background To compare the prevalence of healthy aging among adults age 70 and older from 5 European countries recruited for the DO-HEALTH clinical trial. Participants were selected for absence of prior major health events. Methods Cross-sectional analysis of DO-HEALTH baseline data. All 2,157 participants (mean age 74.9, SD 4.4; 61.7% women) were included and 2,123 had data for all domains of the healthy aging status (HA) definition. HA was assessed based on the Nurses` Health Study (NHS) definition requiring four domains: no major chronic diseases, no disabilities, no cognitive impairment (Montreal Cognitive Assessment, MoCA ≥25), no mental health limitation (GDS-5 <2, and no diagnosis of depression). Association between HA and age, BMI, gender, and physical function (sit-to-stand, gait speed, grip strength) was assessed by multivariate logistic regression analyses adjusting for center. Results Overall, 41.8% of DO-HEALTH participants were healthy agers with significant variability by country: Austria (Innsbruck) 58.3%, Switzerland (Zurich, Basel, Geneva) 51.2%, Germany (Berlin) 37.6%, France (Toulouse) 36.7% and Portugal (Coimbra) 8.8% (p <0.0001). Differences in prevalence by country persisted after adjustment for age. In the multivariate model, younger age (OR = 0.95, 95% CI 0.93 to 0.98), female gender (OR = 1.36, 95% CI 1.03 to 1.81), lower BMI (OR = 0.94, 95% CI 0.91 to 0.96), faster gait speed (OR = 4.70, 95% CI 2.68 to 8.25) and faster performance in sit-to-stand test (OR = 0.90, 95% CI 0.87 to 0.93) were independently and significantly associated with HA. Conclusions Despite the same inclusion and exclusion criteria preselecting relatively healthy adults age 70 years and older, HA prevalence in DO-HEALTH varied significantly between countries and was highest in participants from Austria and Switzerland, lowest in participants from Portugal. Independent of country, younger age, female gender, lower BMI and better physical function were associated with HA. Trial registration DO-HEALTH was registered under the protocol NCT01745263 at the International Trials Registry (clinicaltrials.gov), and under the protocol number 2012–001249-41 at the Registration at the European Community Clinical Trial System (EudraCT).

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“…However, for patients with one or more repetitions of the 5-STS test, we imputed an estimated time, as recommended, 20 and as described elsewhere. 21 Model presentation. We generated an easy-to-use point assignment system, which was generated by applying regression coefficients to categories of each variable, as described previously, 22 and defined as an index.…”

Section: Model Development Internal Validation and Predictive Perform...mentioning

confidence: 99%

Development of the ESEx index: a tool for predicting risk of recurrent severe COPD exacerbations

Valera-Novella

Bernabeu-Mora

Montilla-Herrador

et al. 2023

Therapeutic Advances in Chronic Disease

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Background: In chronic obstructive pulmonary disease (COPD), multiple recurrent severe exacerbations that require hospitalization can occur. These events are strongly associated with death and other clinical complications. Objectives: We aimed to develop a prognostic model that could identify patients with COPD that are at risk of multiple recurrent severe exacerbations within 3 years. Design: Prospective cohort. Methods: The derivation cohort comprised patients with stable, moderate-to-severe COPD. Multivariable logistic regression analyses were performed to develop the final model. Based on regression coefficients, a simplified index (ESEx) was established. Both, model and index, were assessed for predictive performance by measuring discrimination and calibration. Results: Over 3 years, 16.4% of patients with COPD experienced at least three severe recurrent exacerbations. The prognostic model showed good discrimination of high-risk patients, based on three characteristics: the number of severe exacerbations in the previous year, performance in the five-repetition sit-to-stand test, and in the 6-minute-walk test. The ESEx index provided good level of discrimination [areas under the receiver operating characteristic curve (AUCs): 0.913]. Conclusions: The ESEx index showed good internal validation for the identification of patients at risk of three recurrent severe COPD exacerbations within 3 years. These tools could be used to identify patients who require early interventions and motivate patients to improve physical performance to prevent recurrent exacerbations.

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Prognostic value of the five-repetition sit-to-stand test for mortality in people with chronic obstructive pulmonary disease

Cited by 14 publications

References 30 publications

Six-Minute Walking Test and 30 Seconds Chair-Stand-Test as Predictors of Mortality in COPD – A Cohort Study

Six-Minute Walking Test and 30 Seconds Chair-Stand-Test as Predictors of Mortality in COPD – A Cohort Study

Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries

Development of the ESEx index: a tool for predicting risk of recurrent severe COPD exacerbations

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