Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia: A systematic review

Morais, Everton Freitas de; Pinheiro, Juliana Campos; Lira, Jadson Alexandre Silva; Mafra, Rodrigo Porpino; Barboza, Carlos Augusto Galvão; Souza, Lélia Batista de; Freitas, Roseana A.

doi:10.4317/medoral.23305

Cited by 5 publications

(6 citation statements)

References 47 publications

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“…After duplicate elimination, 3924 records were considered potentially eligible and screened according to titles and abstracts, leaving a sample of 92 studies for full text evaluation. Finally, 85 studies meeting all eligibility criteria were included for critical analysis and evidence synthesis in our scoping review [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , …”

Section: Resultsmentioning

confidence: 99%

“…A meta-analysis [ 59 ] studied the relative frequency of CDH1 gene methylation—encoding E-cadherin—in oral cancer, demonstrating that this epigenetic mechanism may be involved in the loss of expression of this relevant adhesion molecule. One line of evidence points to the scarcity of existing studies on transcription factors involved in EMT [ 26 , 35 , 39 , 40 , 75 ]. In this regard, only a systematic review and meta-analysis [ 75 ], performed on a small number of primary level studies, showed that Twist overexpression did not influence the survival of oral cancer patients, although these results are not very robust and perhaps a larger sample size may reveal the actual prognostic influence of this marker.…”

Section: Discussionmentioning

confidence: 99%

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Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews

González‐Moles

Warnakulasuriya

López-Ansio

et al. 2022

Cancers

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In 2000 and 2011, Hanahan and Weinberg published two papers in which they defined the characteristics that cells must fulfil in order to be considered neoplastic cells in all types of tumours that affect humans, which the authors called “hallmarks of cancer”. These papers have represented a milestone in our understanding of the biology of many types of cancers and have made it possible to reach high levels of scientific evidence in relation to the prognostic impact that these hallmarks have on different tumour types. However, to date, there is no study that globally analyses evidence-based knowledge on the importance of these hallmarks in oral and oropharyngeal squamous cell carcinomas. For this reason, we set out to conduct this scoping review of systematic reviews with the aim of detecting evidence gaps in relation to the relevance of the cancer hallmarks proposed by Hanahan and Weinberg in oral and oropharyngeal cancer, and oral potentially malignant disorders, and to point out future lines of research in this field.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews

González‐Moles

Warnakulasuriya

López-Ansio

et al. 2022

Cancers

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“…A relevant fact of the EMT process is its reversible character, so that these cells can re-express E-cadherin and recover both their inter-cellular junctions and their polygonal epithelial morphology, which seems necessary for metastatic colonies to successfully implant and reach the category of macrometastasis [ 179 ]. The EMT phenomenon is governed by the actions of some transcription factors (Snal, Slug, Twist, zab1/2) that activate genes involved in the process [ 180 , 181 , 182 , 183 , 184 ], especially in the loss of E-cadherin [ 185 , 186 , 187 ]. An interesting observation refers to the fact that the EMT phenomenon is not homogeneous in a tumor, appearing more clearly in the peripheral areas, just in the invasion zones, which suggests that perhaps some stromal stimuli or a factor from the peritumoral inflammatory infiltrate may constitute driving forces of EMT [ 188 , 189 ].…”

Section: Discussionmentioning

confidence: 99%

Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses

González‐Moles

Pino

Ramos‐García

2022

IJMS

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Oral lichen planus (OLP) is a common chronic inflammatory disease of unknown etiology and likely autoimmune nature that is currently considered an oral potentially malignant disorder, implying that patients suffering from this process are at risk of developing oral cancer in their lifetime. The molecular alterations that develop in OLP and that make the affected oral epithelium predisposed to malignancy are unknown, although, as in other autoimmune diseases (ulcerative colitis, primary biliary cirrhosis, etc.), they may be linked to oncogenesis-promoting effects mediated by the inflammatory infiltrate. So far there is no in-depth knowledge on how these hallmarks of cancer are established in the cells of the oral epithelium affected by OLP. In this scoping review of systematic reviews and meta-analyses the state of evidence based knowledge in this field is presented, to point out gaps of evidence and to indicate future lines of research. MEDLINE, Embase, Cochrane Library and Dare were searched for secondary-level studies published before October 2022. The results identified 20 systematic reviews and meta-analyses critically appraising the hallmarks tumor-promoting inflammation (n = 17, 85%), sustaining proliferative signaling (n = 2, 10%), and evading growth suppressors (n = 1, 5%). No evidence was found for the other hallmarks of cancer in OLP. In conclusion, OLP malignization hypothetically derives from the aggressions of the inflammatory infiltrate and a particular type of epithelial response based on increased epithelial proliferation, evasion of growth-suppressive signals and lack of apoptosis. Future evidence-based research is required to support this hypothesis.

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“…22 Previous studies indicated that these EMT markers may be involved in the malignant transformation of patients with oral dysplasia. 23 Although the EMT process promoted by lncRNAs has been proposed as a critical mechanism for the acquisition of the malignant phenotype in OSCC, [24][25][26] the dysregulation of EMT-related proteins by lncRNAs in OPMD was unknown. In the gain-of-function studies on LOLA1 in Leuk1, the reduction in E-cadherin expression and upregulation of Vimentin and N-cadherin expression F I G U R E 6 Schematic for the regulatory relationship among LOLA1, AKT, and GSK-3β in OL.…”

Section: Discussionmentioning

confidence: 99%

A novel lncRNA LOLA1 may predict malignant progression and promote migration, invasion, and EMT of oral leukoplakia via the AKT/GSK‐3β pathway

Liu¹,

Yao²,

Shi³

et al. 2021

J of Cellular Biochemistry

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Although dysregulation and dysfunction of long noncoding RNAs (lncRNAs) have been implicated in malignant behavior of oral squamous cell carcinoma (OSCC), whether aberrant lncRNAs play a role in the carcinogenesis of oral leukoplakia (OL) as the best-known precursor of OSCC remains undetermined. Differentially expressed lncRNAs in the occurrence and progression of OL were studied by microarray and quantitative reversetranscription polymerase chain reaction (qRT-PCR). We found a novel key lncRNA n386251 that we named LOLA1 (lncRNA oral leukoplakia progressed associated 1) in the OL progression. The results of qRT-PCR revealed that LOLA1 aberrant expression was validated in tissue samples and cell lines from the normal oral mucosa, OL to OSCC. Fluorescent in situ hybridization showed that LOLA1 expression localized predominately at the cytoplasm of Leuk1 cells. Cell function assays showed that LOLA1 significantly influenced cell migration, invasion, and epithelial-mesenchymal transition (EMT) protein expression. Potential mechanism experiments revealed that AKT/GSK-3β signaling was involved in the regulatory mechanism of LOLA1 in OL progression. Remarkably, Kaplan-Meier analysis revealed that LOLA1 overexpression could predict malignant events of OL progression to OSCC. In conclusion, the current study for the first time profiled and validated the key lncRNAs related to OL progression. Importantly, we demonstrated that a novel lncRNA LOLA1 upregulation was associated with OL malignant progression, suggesting LOLA1 may be a predictive biomarker. Moreover, LOLA1 may promote migration, invasion, and EMT process in OL malignant progression via AKT/GSK-3β pathway.

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Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia: A systematic review

Cited by 5 publications

References 47 publications

Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews

Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews

Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses

A novel lncRNA LOLA1 may predict malignant progression and promote migration, invasion, and EMT of oral leukoplakia via the AKT/GSK‐3β pathway

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