Prognostic value of the International Society on Thrombosis and Haemostasis scoring system for overt disseminated intravascular coagulation in emergency department sepsis

Yin, Qin; Liu, B.; Chen, Yun-Xia; Zhao, Yongmei; Li, C.

doi:10.1007/s15010-014-0600-x

Cited by 6 publications

(13 citation statements)

References 32 publications

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“…Park et al [1] showed that there was a statistically significant correlation between D-D levels and DIC score. Yin et al [15] defined D-D levels <0.55 and <5.5 lg/mL as 2 points and 3 points, respectively. As the accuracy of D-D estimations with current assay systems has not been internationally standardized, the precise definitions of D-D cutoff levels are meaningfully limited to the scoring system.…”

Section: Introductionmentioning

confidence: 99%

Efficacy evaluation of D‐dimer and modified criteria in overt and nonovert disseminated intravascular coagulation diagnosis

Sha

et al. 2016

Int J Lab Hematology

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Section: Introductionmentioning

confidence: 99%

Efficacy evaluation of D‐dimer and modified criteria in overt and nonovert disseminated intravascular coagulation diagnosis

Sha

et al. 2016

Int J Lab Hematology

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“…The prevalence of overt DIC by ISTH criteria, was shock patients were included in that study. [6] The ISTH DIC score is commonly used in clinical setting and associated with adverse outcomes in sepsis patients. [16][17][18][19][20] The result of our study also demonstrate the prognostic value of DIC to identify high risk patients…”

Section: Discussionmentioning

confidence: 99%

“…Disseminated intravascular coagulation (DIC), which leads to fibrin thrombosis, microvascular obstruction, and decreased oxygen delivery resulting in organ failure. [6,7] Although previous studies have reported an association between DIC and mortality of sepsis patients in intensive care units, few studies have evaluated patients with septic shock attending emergency department (ED). [8,9] Furthermore, there is no study about the prevalence and prognostic value of DIC in septic shock patients following the new definition of septic shock.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence and Significance of Overt Disseminated Intravascular Coagulation in Patients with Septic Shock in the Emergency Department According to the Third International Consensus Definition

Cho

Ryoo

et al. 2016

Korean J Crit Care Med

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Background: The prevalence and prognostic value of overt disseminated intravascular coagulation (DIC) in patients with septic shock presenting to emergency departments (EDs) is poorly understood, particularly following the release of a new definition of septic shock. The purpose of this study was to investigate the prevalence and prognostic value of DIC in septic shock. Methods: We performed retrospective review of 391 consecutive patients with septic shock admitting to the ED of tertiary care, university-affiliated hospital during a 16-month. Septic shock was defined as fluid-unresponsive hypotension requiring vasopressor to maintain a mean arterial pressure of 65 mmHg or greater, and serum lactate level ≥ 2 mmol/L. Overt DIC was defined as an International Society on Thrombosis and Hemostasis (ISTH) score ≥ 5 points. The primary endpoint was 28-day mortality. Results: Of 391 patients with septic shock, 290 were included in the present study. The mean age was 65.6 years, the 28-day mortality rate was 26.9%, and the prevalence of overt DIC was 17.6% (n = 51) according to the ISTH score. The median DIC score was higher in non-survivors than in survivors (5.0 vs. 2.0, p = 0.001). Significant higher risk of mortality was observed in overt DIC patients compared to those without (28.2% vs. 13.7%, p = 0.005). Multivariable logistic regression analysis identified DIC to be independently associated with 28-day mortality (odds ratio, 2.689 [95% confidence interval, 1.390-5.201]). Conclusions: Using the ISTH criteria of DIC, overt DIC in septic shock was found to be common among patients admitting to the ED and to be associated with higher mortality when it is accompanied with septic shock. Efforts are required to identify presence of overt DIC during the initial treatment of septic shock in patients presenting the the ED.

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Section: Diagnósticounclassified

“…La valoración propuesta por la ISHT, por ejemplo, asigna un puntaje que, de ser mayor o igual a cinco, se considera diagnóstico (34) ; los cálculos para estas escalas tienden a basarse en pruebas de laboratorio de rutina centradas en medir el consumo de plaquetas o factores de coagulación (35) . En la tabla 1 se pueden observar los criterios propuestos por la ISHT con su respectivo puntaje (34) . Algunos autores consideran que, no poder diagnosticar la CID en sus etapas más tempranas a partir de los criterios actuales, obligan a que estos sean reemplazados o acompañados por otras pruebas que puedan detectar y clasificar la CID incluso cuando es asintomática (36) .…”

Section: Diagnósticounclassified

Coagulación intravascular diseminada: Una revisión de tema

Hernández-Martínez

Martínez-Sánchez

2018

Univ. Salud

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Introducción: La Coagulación Intravascular Diseminada, es un síndrome secundario a patologías subyacentes, donde la activación localizada de la coagulación y la respuesta inflamatoria generalizada, pueden llevar a daños tisulares y microvasculares. Se ha reportado una prevalencia del 10,8% en varias unidades de cuidados intensivos de Colombia; su presentación en el contexto de sepsis es diferente según el tipo de infección. Objetivo: Realizar una revisión de la literatura de los conceptos más destacados de la Coagulación Intravascular Diseminada. Materiales y métodos: Se realizó una revisión por medio de la búsqueda de artículos originales, revisiones sistemáticas y narrativas, en las bases de datos PubMed y ScienceDirect y en el buscador Google Académico; se seleccionaron 80 artículos, de los cuales se incluyeron 51. Se tuvo en cuenta publicaciones en español, inglés y francés, con fecha de publicación menor o igual a 5 años. Resultados: Se realizó la descripción sobre tratamiento, etiología, presentación clínica y diagnóstico de la Coagulación Intravascular Diseminada, haciendo especial énfasis en los estudios sobre marcadores moleculares y nuevas alternativas terapéuticas. Conclusión: La Coagulación Intravascular Diseminada es una complicación que contribuye a aumentar la morbilidad y la mortalidad, cuyo pronto diagnóstico y tratamiento aportan significativamente a una mejor evolución clínica.

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Prognostic value of the International Society on Thrombosis and Haemostasis scoring system for overt disseminated intravascular coagulation in emergency department sepsis

Abstract: The ISTH score is a valuable scoring system in the prognosis evaluation in ED sepsis.

Cited by 6 publications

References 32 publications

Efficacy evaluation of D‐dimer and modified criteria in overt and nonovert disseminated intravascular coagulation diagnosis

Efficacy evaluation of D‐dimer and modified criteria in overt and nonovert disseminated intravascular coagulation diagnosis

The Prevalence and Significance of Overt Disseminated Intravascular Coagulation in Patients with Septic Shock in the Emergency Department According to the Third International Consensus Definition

Coagulación intravascular diseminada: Una revisión de tema

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