“…Data synthesis:A total of four hundred and ve potentially relevant publications were found according to our initial search strategy,one hundred and sixteen publications from PubMed/Medline,two hundred and eighty-nine publications from Embase.There were three hundred and one publications after duplicate publications were removed;of these,we excluded two hundred and sixty-eight articles because the title or abstract did not meet the eligibility criteria.Eight systematic reviews,four studies on metastatic breast cancer,and eleven non-neoadjuvant chemotherapy were further excluded. Eventually,nine studies were identi ed as eligible for our analysis,including nine independent studies for OS [11][12][13][14][15][16][17][18][19],six studies for RFS [11,12,[15][16][17][18],and three for DFS [13,14,19].The ow chart of the literature search and study selection is shown in gure 1. Subsequently,subgroup analysis was performed based on different time intervals.…”