Prognostic value of the nutritional risk index in patients with newly diagnosed multiple myeloma

Abstract

The nutritional risk index (NRI), which is based on weight and albumin levels, is closely associated with the prognosis of many cancers. However, its prognostic value has not been investigated in patients with newly diagnosed multiple myeloma (NDMM). We aimed to assess the association between the NRI and survival outcomes in patients with NDMM. We retrospectively collected and analyzed clinical and laboratory data from patients with NDMM between 2005 and 2019 at our center. Patients were stratified into the high NRI (> 89) and low NRI (≤ 89) groups for prognostic analysis. The NRI and other variables were also explored to evaluate their prognostic value for overall survival (OS). A total of 638 patients diagnosed with NDMM were retrospectively included. Patients in the high NRI group had a significantly better median OS than those in the low NRI group (64 months vs 43 months, p < 0.001). In the multivariate analysis, a high NRI was shown to be an independent prognostic factor for OS (hazard ratio, 0.758; 95% confidence interval, 0.587–0.977; p = 0.033). Age, performance status, transplant status, and lactate dehydrogenase level were also independent prognostic factors for OS. In conclusion, our study demonstrates that the NRI is a simple and useful predictor of survival outcomes in patients with NDMM.

The association between an inflammation-based nutritional tool (Glasgow Prognostic Score) and length of hospital stay in patients with haematological cancer

“…The major downside is that these parameters alone can easily be swayed by non-nutritional factors such as hydration status [9], which is likely inaccurate in haematological cancer due to large intravenous infusions during treatment and changes in organ function [10]. Other combined parameters such as patient-generated subjective global assessment (PG-SGA) [5,11], Nutrition Risk Index(NRI) [12], and Controlling Nutritional Status (CONUT) [13] are attempted to permit more accurate risk strati cation, but the weakness is comparatively di cult to use and nutrition training is needed [14]. Besides, previous studies mainly focus on single diagnosis (acute leukaemia mostly) and thus can be incomprehensive.…”

Geriatric nutritional risk index as a predictor of prognosis in hematologic malignancies: a systematic review and meta-analysis

“…Multiple studies have confirmed that baseline nutrition status is a common factor associated with decreased overall survival time in patients with HMs undergoing chemotherapy and allogeneic hematopoietic cell transplantation (HCT) (10)(11)(12)(13)(14). Moreover, it has been proposed that nutritional treatment would improve the prognosis in patients with HMs before HCT (15).…”