Prognostic value of the preoperative prognostic nutritional index in oldest-old patients with colorectal cancer

Tominaga, Tetsuro; Nonaka, Takashi; Hisanaga, Makoto; Fukuda, Akiko; Tanoue, Yukinori; Yoshimoto, Takafumi; Hidaka, Shigekazu; Sawai, Terumitsu; Nagayasu, Takeshi

doi:10.1007/s00595-019-01910-w

Cited by 29 publications

(31 citation statements)

References 43 publications

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“…The PNI, which is calculated using serum albumin and the peripheral lymphocyte count, is a simple and useful score for predicting the prognosis of patients with various cancers 30 . The PNI was calculated using the following formula: PNI = serum albumin level (g/dL) + 5 × total lymphocyte count 21 .…”

Section: Methodsmentioning

confidence: 99%

The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients undergoing resection for colorectal cancer

Hayama

Ozawa

Okada

et al. 2020

Sci Rep

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the controlling nutritional Status (conUt) score is a marker of nutrition and is associated with poor survival in various kinds of cancers. However, no reports have yet compared risk factors for colorectal cancer recurrence using a nutritional index. We assessed the predictive value of the conUt score compared with the modified Glasgow Prognostic Score (mGPS) and Prognostic Nutritional Index (pni) in colorectal cancer (cRc) patients. We performed a retrospective cohort study of the medical records of 336 consecutive patients with stage I-I I I CRC who underwent curative resection at a single institution in 2012-2017. Univariate and multivariate analyses were conducted to identify prognostic factors associated with relapse-free survival (RFS) and overall survival (OS). The low CONUT score group exhibited higher RFS and longer OS compared to the high CONUT score group (82.2% vs. 63.3%, p = 0.002 and 95.5% and 86.2%, p = 0.005, respectively). The Akaike's information criterion values of each index for RFS and OS were superior in CONUT score (723.71 and 315.46, respectively) compared to those of PNI (726.95 and 316.52) and mGPS (728.15 and 318.07, respectively). The conUt score was found to be a good predictor of RfS and oS in patients with resectable cRc. Abbreviations AIC Akaike's information criterion AJCC American Joint Committee on Cancer CA19-9 Carbohydrate antigen 19-9 CEA Carcinoembryonic antigen CONUT Controlling Nutritional Status CRC Colorectal cancer CRP C-reactive protein mGPS modified Glasgow Prognostic Score OS Overall survival PNI Prognostic nutritional index RFS Relapse-free survival Colorectal cancer (CRC), one of the most common and aggressive malignancies, is the fourth-leading cause of cancer-related death worldwide 1. The Controlling Nutritional Status (CONUT) score-which is comprised of the serum values of albumin (ALB) , total lymphocyte count (TLC), and total cholesterol-is considered a potential predictor of poor outcomes in several types of malignances, including colorectal cancer 2,3. Two nutritional

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Section: Methodsmentioning

confidence: 99%

The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients undergoing resection for colorectal cancer

Hayama

Ozawa

Okada

et al. 2020

Sci Rep

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“…Similarly, Mohri et al analyzed 365 CRC patients who underwent curative resection, and reported that PNI < 45 independently affected OS [ 72 ]. On the other hand, Tominaga et al established the optimal cutoff value of PNI as 42.4 by using ROC analysis [ 73 ]. They evaluated 84 elderly CRC patients (≥85 years) who underwent curative resection and reported that low PNI was independently associated with OS and RFS.…”

Section: Albumin-related Markersmentioning

confidence: 99%

Inflammation-Related Biomarkers for the Prediction of Prognosis in Colorectal Cancer Patients

Yamamoto

Kawada

Obama

2021

IJMS

240

140

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Colorectal cancer (CRC) is the leading cause of cancer deaths around the world. It is necessary to identify patients with poor prognosis or with high risk for recurrence so that we can selectively perform intensive treatments such as preoperative and/or postoperative chemotherapy and extended surgery. The clinical usefulness of inflammation-related prognostic biomarkers available from routine blood examination has been reported in many types of cancer, e.g., neutrophil–lymphocyte ratio (NLR), lymphocyte–C-reactive protein ratio (LCR), platelet–lymphocyte ratio (PLR), lymphocyte–monocyte ratio (LMR), and so on. Moreover, some scoring systems based on circulating blood cell counts and albumin concentration have been also reported to predict cancer patients’ prognosis, such as the Glasgow prognostic score (GPS), systemic inflammation score (SIS), and prognostic nutritional index (PNI). The optimal biomarker and optimal cutoff value of the markers can be different depending on the cancer type. In this review, we summarize the prognostic impact of each inflammation-related marker in CRC.

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“…Allin et al reported that patients with invasive breast cancer and diagnostic CRP levels >3mg/L had a 1.7fold increased risk of death from breast cancer compared to patients with diagnostic CRP levels <1mg/L (30). Biological mechanisms associated with elevated CRP lebels and poor cancer prognosis may explain in ammation in the tumor microenvironment.…”

Section: Discussionmentioning

confidence: 99%

“…The PNI calculated using serum albumin and the peripheral lymphocyte count is a simple and useful score for predicting the prognosis for various cancer patients (30), where PNI = serum albumin level (g/dL) + 5 × total lymphocyte count (31). Onodera reported that this index provided an accurate, quantitative estimate of operative risk (32).…”

Section: Pnimentioning

confidence: 99%

A New Risk Model Predicting Overall Survival Using Preoperative Nutritional and Inflammation Status (NIS) in Patients After Curative Resection of Colorectal Cancer

Hayama¹,

Ozawa²,

Tsukamoto³

et al. 2021

Preprint

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It has been shown that nutritional status correlates with survival in patients with various kinds of cancers. Besides, cancer causes inflammation which has been suggested to stimulate cancer progression. Therefore, inflammation status also has shown to reflect prognosis of cancers. In this study, we evaluated several kinds of nutritional and inflammation parameters in preoperative blood samples and constructed new risk model predicting a survival in patients with CRC (colorectal cancers). We retrospectively examined 286 patients with stage I-III CRC who had undergone curative resection in Teikyo University Hospital between 2013 to 2017. The association between overall survival (OS) and preoperative body mass index, albumin (Alb), cholesterol (Chol), and lymphocyte count, white blood cell count (WBC), neutrophil count (Neu), platelet count (Plt), C-reactive protein (CRP) were examined using Kaplan-Meier curve and log rank test. and eventually Alb, Chol, Neu, Plt, and CRP were shown to correlate with OS. Alb, Chol, Neu, Plt, and CRP were shown to correlate with OS. We constructed a new risk model (NIS: nutrition inflammation status) using these factors, and compared its usefulness with known models such as CRP-albumin ratio (CAR), Glasgow prognostic score (GPS), prognostic nutritional index (PNI), and neutrophil lymphocyte ratio (NLR). NIS prepared using nutritional indicators and inflammatory findings was useful as a new model for predicting overall survival in patients undergoing curative resection for CRC, compared with known models.

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Prognostic value of the preoperative prognostic nutritional index in oldest-old patients with colorectal cancer

Cited by 29 publications

References 43 publications

The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients undergoing resection for colorectal cancer

The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients undergoing resection for colorectal cancer

Inflammation-Related Biomarkers for the Prediction of Prognosis in Colorectal Cancer Patients

A New Risk Model Predicting Overall Survival Using Preoperative Nutritional and Inflammation Status (NIS) in Patients After Curative Resection of Colorectal Cancer

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