Prognostic value of the pretreatment albumin:globulin ratio combined with adult comorbidity evaluation 27 and TMN staging in patients with squamous cell carcinoma of the maxillary sinus

Zhong, Bin; Rong, Yu; Du, Jing; Chen, F.; Liu, Y.-F.; Liu, S.-X.

doi:10.1016/j.bjoms.2019.11.008

Cited by 5 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Guo et al reported that plasma EBV DNA combined with the TNM staging system further improved the prognostic efficacy of NPC patients 22 . ACE‐27 was able to identify patients at a higher risk of major toxicity and assist in deciding whether to undergo treatment 37‐39 . Sommat et al reported that an ACE27 score of 2 or 3 was significantly associated with overall survival (HR: 2.12, 95% CI: 1.09–4.12) and disease‐free survival (HR: 1.87, 95% CI: 1.02–3.41) in elderly NPC patients, compared with a score of 0 or 1 40 .…”

Section: Discussionmentioning

confidence: 99%

“… 22 ACE‐27 was able to identify patients at a higher risk of major toxicity and assist in deciding whether to undergo treatment. 37 , 38 , 39 Sommat et al reported that an ACE27 score of 2 or 3 was significantly associated with overall survival (HR: 2.12, 95% CI: 1.09–4.12) and disease‐free survival (HR: 1.87, 95% CI: 1.02–3.41) in elderly NPC patients, compared with a score of 0 or 1. 40 Xu et al reported that female NPC patients had better OS benefits than males when treated with IC, 41 which is consistent with a previous study that women have a better NPC prognosis compared with men.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Risk stratification and beneficiary selection among elderly nasopharyngeal carcinoma patients from concurrent chemoradiotherapy combined with induction chemotherapy

Gao

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

Objective This study aims to evaluate the risk stratification among elderly Nasopharyngeal carcinoma (NPC) patients (≥60 years old) and select the beneficiaries from concurrent chemotherapy (CCRT) combined with induction chemotherapy (IC). Materials and Methods A total of 909 elderly non‐metastatic NPC patients treated with cisplatin‐based CCRT or IC + CCRT between January 2007 and December 2016 were included. Prognostic nomograms were generated according to clinical characteristics and serum biomarkers. The survival outcomes of patients treated with CCRT versus IC + CCRT were compared in three well‐matched risk groups (high, medium, and low risk) after PSM analysis. Benefit of IC in people older or younger than 70 years and effect of different IC regimens and cycles on prognosis were analyzed. Results Nomograms of overall survival (OS) (C‐index: 0.64, 95% CI, 0.61–0.89) and disease special survival (DSS) (C‐index: 0.65, 95% CI, 0.62–0.71) showed good prognostic accuracy. The nomogram for DSS included variables of age, gender, ACE, EBV DNA, N stage, and T stage. OS included variables of age, smoking history, ACE, ALB, EBV DNA, N stage, and T stage. The corresponding 5‐year OS rates of high, medium and low risk groups were 87.4%, 82.2%, and 60.9%, respectively (p < 0.001), while the 5‐year DSS rates were 92.2%, 84.3%, and 69.0%, respectively (p < 0.001). In the high risk group, IC + CCRT led to significantly higher 5‐year OS and DSS rate compared with CCRT (5‐year OS rate, 73.5% versus 51.8%, p = 0.006; 5‐year DSS rate, 81.4% versus 61.3%, p = 0.002). While in the medium and low risk groups, OS and DSS were not significantly different (OS: p = 0.259, 0.186; DSS: p = 0.29, 0.094). Subgroup analysis showed in the high risk group, only people younger than 70 years old could benefit from IC. TPF and IC cycles of three could lead to the best survival results. Conclusion Compared with CCRT, OS, and DSS among high risk elderly patients were significantly improved by the addition of IC in patients younger than 70 years old. TPF and three IC cycles were recommended.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk stratification and beneficiary selection among elderly nasopharyngeal carcinoma patients from concurrent chemoradiotherapy combined with induction chemotherapy

Gao

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…In another hand, malnutrition is a particular factor affecting the prognosis and deterioration of patients. ALB is mainly synthesized in liver parenchyma and is the main component of serum protein, which is often used to reflect the nutritional status of the body (23). If there is a sufficient amount of ALB, polyunsaturated fatty acids (especially docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid) are mobilized from the liver, and contribute to the formation of cell-bioactive lipids, such as hydrolyzed protein and the protective blood-brain barrier (24).…”

Section: Discussionmentioning

confidence: 99%

Early albumin level and mortality in hemodialysis patients: a retrospective study

Tang¹,

Wang²,

Luo³

et al. 2021

Ann Palliat Med

View full text Add to dashboard Cite

Background: Hypoalbuminemia is a significant risk factor of cardiovascular disease and all-cause death in patients undergoing conventional hemodialysis (HD). However, the albumin (ALB) level of these dialysis patients runs through the whole process of dialysis, and the prognostic value of serum ALB in the early stage of HD and the relationship between the early ALB value and death in HD patients has not been reported. Methods:The data of 447 patients with HD were retrospectively analyzed. The patients were stratified into three ALB (g/L) groups: low, ALB ≤34.2; moderate, 34.3< ALB <40.1; high, ALB ≥40.2. Survival trends of the three groups were analyzed by the Kaplan-Meier method.Results: Comparison of the clinical data among the three groups showed a positive correlation between Hb, RBC, K + , Ca 2+ , Mg 2+ , and PHOS (P<0.05), but a negative correlation between age and high-sensitivity C-reactive protein (hsCRP) (P<0.05). The ALB level in early HD patients was an independent predictor of death [hazard ratio (HR) =0.945; 95% confidence interval (CI): 0.916-0.976; P=0.000], while age and hsCRP were protective factors (HR =1.048, 95% CI: 1.028-1.067, P=0.000; HR =1.049, 95% CI: 1.024-1.075, P=0.000). The estimated median overall survival (OS) at early HD was 56.00 months in the low ALB group, 83.00 months in the moderate ABL group, and 95.00 months in the high ALB group. The Kaplan-Meier estimate of survival showed a significant difference in OS among the three groups (log-rank P=0.000). Conclusions:The early ALB level not only reflects the nutritional and chronic inflammation status of HD patients, but can also predict the prognosis, which has guiding significance for the management of HD patients.

show abstract

The efficacy of albumin–globulin ratio to predict prognosis in cancer patients

Roberts,

Delladio,

Price

et al. 2023

Int J Clin Oncol

View full text Add to dashboard Cite

Prognostic value of the pretreatment albumin:globulin ratio combined with adult comorbidity evaluation 27 and TMN staging in patients with squamous cell carcinoma of the maxillary sinus

Cited by 5 publications

References 28 publications

Risk stratification and beneficiary selection among elderly nasopharyngeal carcinoma patients from concurrent chemoradiotherapy combined with induction chemotherapy

Risk stratification and beneficiary selection among elderly nasopharyngeal carcinoma patients from concurrent chemoradiotherapy combined with induction chemotherapy

Early albumin level and mortality in hemodialysis patients: a retrospective study

The efficacy of albumin–globulin ratio to predict prognosis in cancer patients

Contact Info

Product

Resources

About