An analysis of the literature data showed unidirectional trends in the risks of developing cardiovascular pathology associated with depression, as well as a significant prevalence of factors of psycho-emotional stress, in particular depression, mainly in female populations. It has been shown that such trends are probably related both to the physiological characteristics of the female body and to variations in the expression of depression/major depression, which in turn affect cardiovascular risks. In accordance with this paradigm, to improve the prevention of cardio-vascular diseases (CVD) in various regions, it is necessary to create an infrastructure that can ensure the availability of information and educational technologies and appropriate advice on identifying and monitoring psychosocial risk factors (PRF) for all categories of the population, depending on regional characteristics.