Prognostic Value of the Site of Distant Metastasis and Surgical Interventions in Metastatic Gastric Cancer: A Population-Based Study

Li, Yinghua; Xie, Danna; Chen, Xiaojing; Hu, Teng; Lu, Simin; Han, Yunwei

doi:10.1177/1533033820964131

Cited by 9 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 , 31 This may be related to the limited effective treatment for MOM. Meantime, the same with previous literature, 27 , 32 our data showed that patients received surgery, chemotherapy or radiation therapy earned higher survival rates, indicated that despite elderly patients have reduced physical function, positive treatment could still provide survival benefits if the body could tolerate it. With further research, the association between gender and lung cancer prognosis is being increasingly reported.…”

Section: Discussionsupporting

confidence: 89%

Construction and validation of prognostic nomograms for elderly patients with metastatic non‐small cell lung cancer

Sun

Liu

Yang

et al. 2022

Clinical Respiratory J

View full text Add to dashboard Cite

Background Metastatic non‐small cell lung cancer (NSCLC) is mostly seen in older patients and is associated with poor prognosis. There is no reliable method to predict the prognosis of elderly patients (≥60 years old) with metastatic NSCLC. The aim of our study was to develop and validate nomograms which accurately predict survival in this group of patients. Methods NSCLC patients diagnosed between 2010 and 2015 were all identified from the Surveillance, Epidemiology, and End Results (SEER) database. Nomograms were constructed by significant clinicopathological variables (p < 0.05) selected in multivariate Cox analysis regression. Results A total of 9584 patients met the inclusion criteria and were randomly allocated in the training (n = 6712) and validation (n = 2872) cohorts. In training cohort, independent prognostic factors included age, gender, race, grade, tumor site, pathology, T stage, N stage, radiotherapy, surgery, chemotherapy, and metastatic site (p < 0.05) for lung cancer‐specific survival (LCSS) and overall survival (OS) were identified by the Cox regression. Nomograms for predicting 1‐, 2‐, and 3‐years LCSS and OS were established and showed excellent predictive performance with a higher C‐index than that of the 7th TNM staging system (LCSS: training cohort: 0.712 vs. 0.534; p < 0.001; validation cohort: 0.707 vs. 0.528; p < 0.001; OS: training cohort: 0.713 vs. 0.531; p < 0.001; validation cohort: 0.710 vs. 0.528; p < 0.001). The calibration plots showed good consistency from the predicted to actual survival probabilities both in training cohort and validation cohort. Moreover, the decision curve analysis (DCA) achieved better net clinical benefit compared with TNM staging models. Conclusions We established and validated novel nomograms for predicting LCSS and OS in elderly patients with metastatic NSCLC with desirable discrimination and calibration ability. These nomograms could provide personalized risk assessment for these patients and assist in clinical decision.

show abstract

Section: Discussionsupporting

confidence: 89%

Construction and validation of prognostic nomograms for elderly patients with metastatic non‐small cell lung cancer

Sun

Liu

Yang

et al. 2022

Clinical Respiratory J

View full text Add to dashboard Cite

show abstract

“…This may be why the liver is the first organ of distant metastasis in patients with GC (6). Due to advancements in medical technologies and the continuous improvement of detection methods, cases of liver metastasis can be detected in early or even asymptomatic stages (23).…”

Section: Discussionmentioning

confidence: 99%

Prediction of distant metastasis and survival prediction of gastric cancer patients with metastasis to the liver, lung, bone, and brain: research based on the SEER database

Lin¹,

Wang²,

Zhou³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background: Gastric cancer (GC) is a globally important disease. It is the 5th most common malignancy and the 4th most common cause of death from cancer in the world. Patients with GC are often at an advanced stage when they are first diagnosed, and their overall prognosis is poor due to locally advanced and distant metastasis. This study sought to establish a predictive model of GC distant metastasis and survival that can be used to guide individualized treatment.Methods: Patients diagnosed with GC from the Surveillance, Epidemiology, and End Results database were enrolled in the study. Univariate and multivariate logistic regression analyses were used to identify risk and prognostic factors for GC patients with distant metastasis. The factors were then used to construct nomograms to predict the probability of distant metastasis and the survival time of GC patients. Receiver operating characteristic (ROC) curve and decision curve analyses were used to verify the prediction ability of the nomograms. Results:We established a comprehensive nomogram to predict the survival time of GC patients and 4 nomograms to predict distant metastasis. Nomograms could help oncologists to formulate treatment strategies and provide hospice care under an overall management model.Conclusions: Establishing a prediction model for distant metastasis and the survival of GC patients is of great clinical significance. The prediction of distant metastasis could help clinicians to make individualized assessments of patients and formulate individualized examination measures. Survival prediction models could help oncologists to formulate good treatment strategies and provide hospice care.

show abstract

“…In all survival analyses, patients lost to follow‐up were censored at time lost. The factors in the analysis were chosen as covariates because each is either a known prognostic factor for gastrointestinal cancer or has been shown to be related to health or healthcare disparities 23–30 . Age and year of diagnosis were categorized as binary variables.…”

Section: Methodsmentioning

confidence: 99%

“…The factors in the analysis were chosen as covariates because each is either a known prognostic factor for gastrointestinal cancer or has been shown to be related to health or healthcare disparities. [23][24][25][26][27][28][29][30] Age and year of diagnosis were categorized as binary variables. An age cutoff of 65 was chosen as previous studies have demonstrated increased risk for adverse outcome after treatment of gastrointestinal cancers beginning at age ≥65.…”

Section: Primary Statistical Analysismentioning

confidence: 99%

Surgical treatment of stage IV gastroenteropancreatic neuroendocrine carcinoma: Experience and outcomes in the United States

Kerekes

Frey

Bakkila

et al. 2023

Journal of Surgical Oncology

View full text Add to dashboard Cite

Background and ObjectivesSurgery for metastatic gastroenteropancreatic neuroendocrine carcinoma (GEP‐NEC) has not been well‐studied. This retrospective cohort study describes patients in the United States with stage IV GEP‐NEC and their survival outcomes segregated by surgery.MethodsPatients diagnosed with stage IV GEP‐NEC from 2004 to 2017 in the National Cancer Database were categorized into three groups: no surgery, primary site or metastatic site (“single‐site”) surgery, and primary site and metastatic site (“multisite”) surgery. Factors associated with surgical treatment were identified, and risk‐adjusted overall survival of each group was compared.ResultsOf 4171 patients included, 958 (23.0%) underwent single‐site surgery and 374 (9.0%) underwent multisite surgery. The strongest predictor of surgery was primary tumor type. Compared with no surgery, the risk‐adjusted mortality reduction associated with single‐site surgery ranged from 63% for small bowel (HR = 0.37, 0.23–0.58, p < 0.001) NEC to 30% for colon and appendix NEC (HR = 0.70, 0.61–0.80, p < 0.001), while the mortality reduction associated with multisite surgery ranged from 77% for pancreas NEC (HR = 0.23, 0.17–0.33, p < 0.001) to 48% for colon and appendix NEC (HR = 0.52, 0.44–0.63, p < 0.001).ConclusionsWe observed an association between extent of surgical intervention and overall survival for patients with stage IV GEP‐NEC. Surgical resection should be further investigated as a treatment option for highly‐selected patients with this aggressive disease.

show abstract

Prognostic Value of the Site of Distant Metastasis and Surgical Interventions in Metastatic Gastric Cancer: A Population-Based Study

Cited by 9 publications

References 44 publications

Construction and validation of prognostic nomograms for elderly patients with metastatic non‐small cell lung cancer

Construction and validation of prognostic nomograms for elderly patients with metastatic non‐small cell lung cancer

Prediction of distant metastasis and survival prediction of gastric cancer patients with metastasis to the liver, lung, bone, and brain: research based on the SEER database

Surgical treatment of stage IV gastroenteropancreatic neuroendocrine carcinoma: Experience and outcomes in the United States

Contact Info

Product

Resources

About