Prognostic value of tissue factor in patients with abdominal aortic and iliac arterial aneurysms – preliminary study

Abstract

IntroductionThe decision on the time and choice of strategy of treatment of abdominal aortic aneurysm must be especially carefully balanced. The aim of the study was to evaluate the tissue factor (TF) plasma level as a potential factor useful in anticipation of abdominal aortic aneurysm and/or iliac arterial aneurysm via comparison of plasma TF level in patients with ruptured and non-ruptured aneurysms.Material and methodsThe study included 33 patients with aneurysm (17 operated on electively because of non-ruptured aneurysm and 16 operated on emergently due to ruptured aneurysm), 33 claudicant patients with atherosclerosis of the abdominal aorta and iliac arteries with normal diameter of arteries, and 30 healthy controls. Plasma TF level was assessed by ELISA method using the IMUBIND Tissue Factor ELISA Kit (American Diagnostica Inc.).ResultsThe study showed an increased TF level in patients with aneurysm (134 ±54 pg/ml) and in patients with atherosclerosis without concomitant aneurysm (91 ±30 pg/ml) in comparison with the control group (62 ±20 pg/ml), respectively p < 0.001 and p = 0.008. A significantly higher TF plasma level was observed in patients with ruptured abdominal aortic aneurysms (160 ±57 pg/ml) as compared to patients with non-ruptured aortic aneurysms (109 ±39 pg/ml) or peripheral arterial occlusive disease (91 ±30 pg/ml), respectively p < 0.001 and p < 0.001. The difference in TF level between the group with non-ruptured aortic aneurysms (109 ±39 pg/ml) and the patients with atherosclerosis without aneurysm (91 ±30 pg/ml) was not statistically significant.ConclusionsNo difference in TF level between patients with non-ruptured AAA/IAA and patients with aortic and iliac atherosclerosis without aneurysm indicates that an increased TF plasma level is not specific for any of the above-mentioned vascular pathologies.

Perioperative assessment of changes in tissue factor and its inhibitor in patients with abdominal aortic aneurysm treated using classical and intravascular methods

“…The role of TF as a prognostic factor in AAA rupture was previously studied by Skóra and co-workers revealing higher levels of TF and TFPI in AAA patients [6]. We have also found elevated levels of TF and TFPI in AAA patients compared to the reference group (Table 2), indicating activation of coagulation process in the aorta wall.…”

SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence

“…However, atherosclerosis may be a potential confounder in these studies, since the polymorphisms identified in these reports have been shown to be also associated with other cardiovascular diseases. Similarly, shared disease pathways between AAA and atherosclerosis may contribute to failure of studies, that focus on AAA-specific biomarkers 40 .…”

Evaluation of four commercial ELISAs to measure tissue factor in human plasma

“…Several studies have reported that disease groups, such as cancer, bacterial, and viral infections, and cardiovascular diseases had increased levels of TF-like antigen measured by Imubind [ [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] ] or Quantikine [ 46 , 58 , 59 ] compared with healthy controls ( Table ). These studies report statistically significant increases in TF-like antigen in different disease groups using the Imubind and Quantikine ELISAs.…”