“…Although no correlation with LRC was found, the ΔV 2 weeks with a threshold of 20% showed high NPV. Jaulerry et al showed that tumour regression of 25% at 2 weeks during RT was predictive of CR after RT [7]. However, in the current study, a high number of responding primary tumoral and nodal metastatic lesions showed no substantial volume regression during CRT.…”
“…Although no correlation with LRC was found, the ΔV 2 weeks with a threshold of 20% showed high NPV. Jaulerry et al showed that tumour regression of 25% at 2 weeks during RT was predictive of CR after RT [7]. However, in the current study, a high number of responding primary tumoral and nodal metastatic lesions showed no substantial volume regression during CRT.…”
“…Volumetric analysis during chemotherapy and radiotherapy (RT) has shown variable results [6][7][8]. Although the metabolic response on 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) during CRT reflects the tumour response to CRT, it is also modified by treatmentinduced inflammation [9,10].…”
“…The main result has been better control of primary tumours, whereas the cure rate of patients with nodal involvement has not improved significantly. Nodal involvement is still a strong, independent, prognostic indicator (5,(9)(10)(11)(12). The present paper focuses on the tumour burden of lymph node metastases as an independent prognostic factor.…”
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