Prognostic value of vascular endothelial growth factor in sepsis syndrome

El-Akabawy, Hazem; Hamela, Mohamed Abo; Gaber, Ayman; Abozekry, Ahmed

doi:10.1016/j.ejccm.2016.10.002

Cited by 6 publications

(12 citation statements)

References 33 publications

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“…Two studies indicated an increase in C-type VEGF levels in patients who subsequently died. These results are not consistent with our study, which reveals that increased plasma VEGF-C levels were not related to mortality [13,18].…”

Section: Discussioncontrasting

confidence: 99%

“…In our study, no correlation between plasma VEGF-C levels and the patients' age was observed in agreement with other published studies [13,18].…”

Section: Discussionsupporting

confidence: 93%

“…The septic shock group had higher mortality rates compared to the group with sepsis; however, we were unable to find a significant correlation between plasma VEGF-C levels and mortality [18].…”

Section: Discussioncontrasting

confidence: 74%

“…An important finding in the present study was that higher plasma VEGF-C levels were found in patients in the septic shock group who were undergoing vasoactive treatment. Only two other reports have described a significantly increased plasma VEGF-C level during septic shock [10,18].…”

Section: Discussionmentioning

confidence: 97%

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The Diagnostic and Prognostic Role of Vascular Endothelial Growth Factor C in Sepsis and Septic Shock

Almasy

Szederjesi

Grigorescu

et al. 2020

The Journal of Critical Care Medicine

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IntroductionVariations in the expression of vascular endothelial growth factor (VEGF) could be used as a biomarker in critically ill patients with sepsis and septic shock. Inflammation potently upregulates VEGF-C expression via macrophages with an unpredictable response. This study aimed to assess one of the newer biomarkers (VEGF-C) in patients with sepsis or septic shock and its clinical value as a diagnostic and prognostic tool.Material and methodsThe study involved 142 persons divided into three groups. Group A consisted of fifty-eight patients with sepsis; Group B consisted of forty-nine patients diagnosed as having septic shock according to the Sepsis -3 criteria. A control group of thirty-five healthy volunteers comprised Group C. Severity scores, prognostic score and organ dysfunction score, were recorded at the time of enrolment in the study. The analysis included specificity and sensitivity of plasma VEGF-C for diagnosis of septic shock. Circulating plasma VEGF-C levels were correlated with the APACHE II, MODS and severity scores and mortality.ResultsThe mean (SD) plasma VEGF-C levels in septic shock patients (1374(789) pg./m), on vasopressors at the time of admission to the ICU, were significantly higher 1374(789)pg./mL, compared the mean (SD) plasma VEGF-C levels in sepsis patients (934(468) pg./mL); (p = 0.0005, Student’s t-test.) Plasma VEGF-C levels in groups A and B were shown to be significantly correlated with the APACHE II (r = 0.21, p = 0.02; r = 0.45, p = 0.0009) and MODS score (r = 0.29, p = 0.03; r = 0.4, p = 0.003). There was no association between plasma VEGF-C levels and mortality [p = 0.1]. The cut-off value for septic shock was 1010 pg./ml.ConclusionsVEGF-C may be used as a prognostic marker in sepsis and septic shock due to its correlation with APACHE II values and as an early marker to determine the likelihood of developing MODS. It could be used as an early biomarker for diagnosing patients with septic shock.

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Section: Discussioncontrasting

confidence: 99%

“…In our study, no correlation between plasma VEGF-C levels and the patients' age was observed in agreement with other published studies [13,18].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 74%

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

The Diagnostic and Prognostic Role of Vascular Endothelial Growth Factor C in Sepsis and Septic Shock

Almasy

Szederjesi

Grigorescu

et al. 2020

The Journal of Critical Care Medicine

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“…Thus, this alteration in levels of VEGF depending on the severity of the sepsis may lead to EC damage causing vascular leak and organ damage during sepsis. VEGF levels in systemic circulation have shown a great prognostic value for sepsis syndrome [191]. Thus, any change in the metabolic stages of immune cells can promote an aberrant immune response that can be its overactivation or immunosuppression (Fig.…”

Section: Immunometabolic Reprogramming Among Mdscs During Sepsismentioning

confidence: 99%

Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting

Kumar

2018

Inflammation

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Sepsis is a major health problem all over the world. Despite its existence since the time of Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in both pediatric and adult intensive care units. The most current US FDA-approved drug called recombinant human activated protein C or Drotrecogin-α is also failed in clinical trials and showed similar effects as placebo. The epidemiological data and studies have indicated sepsis as a major socioeconomic burden all over the world. Advances in immunology and genomic medicine have established different immunological mechanisms as major regulators of the pathogenesis of the sepsis. These immunological mechanisms come into action upon activation of several components of the immune system including innate and adaptive immunity. The activation of these immune cells in response to the pathogens or pathogen-associated molecular patterns (PAMPs) responsible for the onset of sepsis is regulated by the metabolic stage of the immune cells called immunometabolism. An alternation in the immunometabolism is responsible for the generation of dysregulated immune response during sepsis and plays a very important role in the process. Thus, it becomes vital to understand the immunometabolic reprograming during sepsis to design future target-based therapeutics depending on the severity. The current review is designed to highlight the importance of immune response and associated immunometabolism during sepsis and its targeting as a future therapeutic approach.

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The effect of thyme essential oil and endothelial progenitor stem cells on lipopolysaccharide‐induced sepsis in C57BL/6 mice

Soltan Dallal,

Siavashi,

Karimaei

et al. 2024

Biotech and App Biochem

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Sepsis is a potentially fatal syndrome related to severe systemic inflammation developed by infection. Despite different antimicrobial therapies, morbidity and mortality rates remain high. Herbs along with cell therapy have been introduced as a promising option to improve the symptoms of sepsis. The present study aimed to evaluate the therapeutic effect of simultaneous administration of thyme essential oil (TEO) and endothelial progenitor stem cells (EPCs) on lipopolysaccharide (LPS)‐induced sepsis in C57BL/6 mice. Sepsis was induced in C57Bl/6J mice by intraperitoneal injection of LPS, followed 2 h later by an intravenous injection of EPCs or oral administration of TEO or simultaneous administration of TEO and EPCs. After 10 days, the complete blood cell, renal and liver factors, serum levels of inflammatory cytokines, and angiogenic factors were measured. Simultaneous treatment with EPCs and TEO significantly increased the survival of mice with sepsis and modulated the inflammatory response by reducing the serum levels of pro‐inflammatory cytokines. Moreover, this treatment significantly reduced the level of white blood cells and neutrophils and increased the number of red blood cells, the percentage of hematocrit, and hemoglobin. The combination of TEO with EPCs decreased organ injuries and was assessed by lower levels of the liver enzymes alanine aminotransferase and aspartate aminotransferase compared to the sepsis group. Administration of EPCs and TEO also significantly improved angiogenic factors, lung function, and toll‐like receptor 4 expression. EPCs in combination with TEO increase survival in the LPS‐induced sepsis mice model by acting on several targets. Thus, the combination of TEO with EPCs can be a feasible approach for the future clinical treatment and control of sepsis.

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Prognostic value of vascular endothelial growth factor in sepsis syndrome

Cited by 6 publications

References 33 publications

The Diagnostic and Prognostic Role of Vascular Endothelial Growth Factor C in Sepsis and Septic Shock

The Diagnostic and Prognostic Role of Vascular Endothelial Growth Factor C in Sepsis and Septic Shock

Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting

The effect of thyme essential oil and endothelial progenitor stem cells on lipopolysaccharide‐induced sepsis in C57BL/6 mice

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