Prognostic Value Of Vascular Invasion In Breast Tumours In She-Dogs (Pilot Study)

Abstract

Breast tumours are the most common neoplasm in intact she-dogs. However, breast tumours in she-dogs differ significantly in morphological features and biological behaviour, so the definition of prognostic factors is relevant. A study on tumour cell dissemination in breast tumours in she-dogs by migration of these cells into blood and lymphatic vessels depending on their histological characteristics and disease stage was conducted. The study of the problem was performed on the basis of the clinic of modern veterinary medicine “Best” in Zaporizhzhia. She-dogs with breast neoplasms of different ages and breeds were used as objects in the proven absence of signs of metastatic lesions of other organs and tissues, including lungs, abdominal organs and bones. The presence of cancer cells in the vessels was determined by the tumour clots formed by them, fixed to the endothelium. The study revealed the presence of angioinvasion regardless of the clinical stage of the tumour process. In this case, the dissemination of tumour cells by migration into lymphatic vessels was observed only in the second clinical stage of breast tumours. In patients with stage 1 breast cancer in the vast majority of cases (66.7% of patients) angioinvasion is registered in the micropapillary invasive carcinomas (ICD-O code 8507/2). Tumour cells in blood vessels were verified in simple cribriform carcinoma (ICD-O code 8201/3) in more than 80% of she-dogs with stage 3 breast cancer. In contrast to the above groups, in patients with stage 2 cancer, migration of tumour cells into both blood and lymphatic vessels was found. Most often the signs of angio- and lymphoinvasion were found in invasive carcinoma mixed type (ICD-O code 8562/3), tubulopapillary carcinoma (ICD-O code 8503/3), and tubular carcinoma (ICD-O code 8211/3) ‒ in 34.1% and 36.8%, 19.3% and 26.3%, 17.0% and 10.5% of cases, respectively. The obtained results allow predicting the probability of penetration of tumour cells into blood and lymphatic vessels with a high degree of reliability, which in the future can better predict the biological behaviour of breast tumours

Prognostic markers of canine mammary tumours: Retrospective study of 142 cases

“…The results presented in this paper correlate with our previous studies that indicate presence of signs of lymphatic / angioinvasion against the background of certain types of tumours of the mammary gland even at the first stages of the development and therefore significance of detecting them for prognosing the biological behaviour of the tumour (Kovalenko & Bilyi, 2021). The determined patterns of significance of presence of tumour emboli for evaluation of the survival rate of cancer patients confirm the limited possibilities of clinical classifications.…”

Мастопатія У Собак І Кішок: Особливості Лікування (Оглядова Інформація)

“…Для лікування новоутворень молочної залози у собак і кішок широко застосовується хірургічна резекція [4]. Важливим є визначення типу пухлини та аналіз прогностичної інформації про неї для призначення відповідного лікування, так як пухлини молочної залози суттєво відрізняються за морфологічними особливостями та біологічною поведінкою [29]. Під час встановлення попереднього діагнозу проводять тонкоголкову пункційну біопсію [22, 55] та цитологічне дослідження, що у собак має задовільну точність, чутливість і специфічність для диференціальної діагностики злоякісних і доброякісних новоутворень та тісно пов'язане з післяопераційним результатом [52].…”

Canine mastopathy (Overview)

“…According to the histological and cytological assessment of dyshormonal dysplasia of the mammary gland (considered a precancerous condition), the pathogenetic role of the migration of neoplastic cells into blood and lymphatic vessels, which is of significant importance in the progression of the disease, is not taken into account (Kovalenko and Bilyi, 2021).…”