Prognostic value of vascularity index for the diagnosis of autoimmune thyroid disease

Banaka, Ioanna; Kaltsas, Gregory; Antoniou, St; Kanakis, George; Zilos, Athanasios; Baltas, Christos; Thomas, Dimitrios

doi:10.5334/jbr-btr.582

Cited by 11 publications

(18 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, thyroid vascularity, as expressed by the left TL VI, was found to be significantly increased in patients with rheumatic diseases (group-1, 2, 3); however, only left ITA PSV was significantly increased in group-1 patients compared to healthy controls (group-4). Group-1 patients demonstrated a tendency to increased vascularity (left TL VI and left ITA PSV) and reduced echogenicity that are both considered to represent early features of AITD [11][12][13].…”

Section: Discussionmentioning

confidence: 97%

“…2a-c). Left TL VI [5.57 % was considered suggestive of autoimmune thyroiditis [12]. Thyroid blood flow was assessed following at least 5 measurements of each left and right ITA.…”

Section: Ultrasonographic Studymentioning

confidence: 99%

“…Additionally, thyroid ultrasound may offer valuable information, particularly where alterations of thyroid autoantibody titers and/or TSH changes may not be diagnostic [9,10]. Reduced thyroid echogenicity, an increased left thyroid lobe vascularity index (TL VI), and an increased left inferior thyroid artery peak systolic velocity (ITA PSV) are important associations predicting progression to AITD [11][12][13], even in the absence of thyroid autoantibodies, which is important as 10 % of HT patients may be seronegative [4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Thyroid-specific changes following treatment with biological therapies in patients with rheumatic diseases

et al. 2015

View full text Add to dashboard Cite

Biological anti-rheumatic agents (BAA) may induce autoimmune phenomena. Evidence on thyroid-specific effects of these agents is relatively limited. We studied prospectively, over 3 years, 36 rheumatic patients treated with BAA (18 Infliximab and 18 Rituximab) and no prior exposure to biological therapies (group-1), with respect to their thyroid function, thyroid antibody titers, and thyroid ultrasonographic parameters, such as left inferior thyroid artery peak systolic velocity (ITA PSV), left thyroid lobe vascularity index (TL VI), and echogenicity. Twenty-eight rheumatic patients treated with disease-modifying anti-rheumatic drugs and/or glucocorticoids (group-2), 21 rheumatic patients not receiving any treatment (group-3), and 49 healthy individuals (group-4) were used for comparison. Thyroid function and autoantibody titers were not significantly altered at any stage irrespectively of the administered BAA, previously unknown autoimmune thyroid disease (AITD) status, and/or concomitant treatment with glucocorticoids. Left ITA PSV was significantly increased in group-1 patients (mean ± SD start: 25.5 ± 14.1 cm/s vs. end: 29.8 ± 11.1 cm/s, p = 0.038 and p < 0.001, respectively). Six group-1, 7 group-2, and 3 group-3 patients developed reduced thyroid echogenicity during follow-up (start: p = 0.003 and end: p < 0.001). Left ITA PSV, left TL VI, and echogenicity changes were not related to alterations in thyroid volume, thyrotropin hormone levels, and/or underlying AITD. Infliximab and Rituximab do not cause any alterations in thyroid function and/or autoimmunity, even in patients with previously undiagnosed AITD. Elevated left ITA PSV and reduced thyroid echogenicity may be early features signaling progression to AITD in patients treated with BAA.

show abstract

Section: Discussionmentioning

confidence: 97%

“…2a-c). Left TL VI [5.57 % was considered suggestive of autoimmune thyroiditis [12]. Thyroid blood flow was assessed following at least 5 measurements of each left and right ITA.…”

Section: Ultrasonographic Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid-specific changes following treatment with biological therapies in patients with rheumatic diseases

et al. 2015

View full text Add to dashboard Cite

show abstract

“…A qualitative assessment of the measurement of echogenicity and its impact on the results obtained in the classification of Hashimoto’s disease was conducted using a statistical approach [41,42]. A discriminant analysis was used for the following five options: …”

Section: Resultsmentioning

confidence: 99%

Influence of the measurement method of features in ultrasound images of the thyroid in the diagnosis of Hashimoto’s disease

Koprowski

Korzyńska

Wróbel

et al. 2012

BioMedical Engineering OnLine

View full text Add to dashboard Cite

IntroductionThis paper shows the influence of a measurement method of features in the diagnosis of Hashimoto’s disease. Sensitivity of the algorithm to changes in the parameters of the ROI, namely shift, resizing and rotation, has been presented. The obtained results were also compared to the methods known from the literature in which decision trees or average gray level thresholding are used.MaterialIn the study, 288 images obtained from patients with Hashimoto’s disease and 236 images from healthy subjects have been analyzed. For each person, an ultrasound examination of the left and right thyroid lobe in transverse and longitudinal sections has been performed.MethodWith the use of the developed algorithm, a discriminant analysis has been conducted for the following five options: linear, diaglinear, quadratic, diagquadratic and mahalanobis. The left and right thyroid lobes have been analyzed both together and separately in transverse and longitudinal sections. In addition, the algorithm enabled to analyze specificity and sensitivity as well as the impact of sensitivity of ROI shift, repositioning and rotation on the measured features.Results and summaryThe analysis has shown that the highest accuracy was obtained for the longitudinal section (LD) with the method of linear, yielding sensitivity = 76%, specificity = 95% and accuracy ACC = 84%. The conducted sensitivity assessment confirms that changes in the position and size of the ROI have little effect on sensitivity and specificity. The analysis of all cases, that is, images of the left and right thyroid lobes in transverse and longitudinal sections, has shown specificity ranging from 60% to 95% and sensitivity from 62% to 89%. Additionally, it was shown that the value of ACC for the method using decision trees as a classifier is equal to 84% for the analyzed data. Thresholding of average brightness of the ROI gave ACC equal to 76%.

show abstract

“…We introduce an experimental method, based on the pixel density of the pleural effusion's sonographic image. We employed the hypoechogenicity index, which has been widely used in ultrasound studies of the thyroid and its diseases but not in the lung (7). To achieve standardization in our method we used the same ultrasound depth and dynamic range for all our patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation of pleural effusions’ grayscale sonographic parameters with fluid’s analysis results

2017

View full text Add to dashboard Cite

IntroductionUntil now, in the sonographic imaging of pleural effusions, the quantitative evaluation of the fluids characteristics was performed indirectly by using other anatomic structures of the thorax as a relative measure of comparison (1). Such quantitative methods are used to assess the fluid's volume but to the best of our knowledge no method exists for the measurement of the fluids' density and other qualitative values. The interpretation of the internal echogenicity of a pleural effusion is based upon the subjective observation and evaluation of each operator. According to the internal echogenicity, effusion can be subclassified as anechoic, complex non-septated, complex septated, and homogenously echogenic (2). Additionally, several visual patterns like swirling (3) or sonographic septations (4,5) have been proven useful as diagnostic predictors for pleural effusions (6). We suggest a quantitative method, based on the pixel density of the pleural effusion's image, in order to evaluate the echogenicity of pleural effusion.

show abstract

Prognostic value of vascularity index for the diagnosis of autoimmune thyroid disease

Cited by 11 publications

References 26 publications

Thyroid-specific changes following treatment with biological therapies in patients with rheumatic diseases

Thyroid-specific changes following treatment with biological therapies in patients with rheumatic diseases

Influence of the measurement method of features in ultrasound images of the thyroid in the diagnosis of Hashimoto’s disease

Correlation of pleural effusions’ grayscale sonographic parameters with fluid’s analysis results

Contact Info

Product

Resources

About