Prognostic values of geriatric nutritional risk index (GNRI) and prognostic nutritional index (PNI) in elderly patients with Diffuse Large B-Cell Lymphoma

Yan, Dongmei; Shen, Ziyuan; Zhang, Shuo; Hu, Lingling; Sun, Qian; Xu, Kailin; Jin, Yingliang; Sang, Wei

doi:10.7150/jca.62340

Cited by 28 publications

(24 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent evidence showed that PNI was closely associated with clinical outcomes of cancer [ 13 , 14 ] and sepsis [ 15 , 16 ]. However, the prognostic role of PNI in the cases with stroke is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

Liu

Yang

Kadasah

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Purpose. The purpose of study was to evaluate the association between prognostic nutritional index (PNI) and all-cause mortality of critically ill patients with stroke. Methods. Clinical data derived from Multiparameter Intelligent Monitoring in Intensive Care were analyzed. The primary endpoint was 30-day all-cause mortality; secondary endpoints were 90-day mortality and one-year cause mortality. The potential prognostic roles of PNI were analyzed by Cox proportional hazard models. The independent prognostic roles of PNI in the cases were analyzed by smooth curve fitting. Results. Concerning 30-day mortality, the HR (95% CI) for a high PNI (≥39.7) was 0.700 (0.544, 0.900; P = 0.00539 ), compared to a low PNI (<39.7). After adjusting for multiple confounders, the HR (95% CI) for a high PNI (≥39.7) was 0.732 (0.547, 0.978; P = 0.03514 ), compared to a low PNI (<39.7). Regarding 90-day and one-year mortality, a similar trend was observed. In addition, a nonlinear association between PNI and 30-day mortality was found. Using recursive algorithm and two-piecewise linear regression model, inflection point (IP) was calculated, which was 49.4. On the right side of the IP, there was a positive relationship between PNI and 30-day mortality, and the effect size, 95% CI, and P value were 1.04 (1.01, 1.07), P = 0.0429 , respectively. On the left of the IP, the effect size, 95% CI, and P value were 0.97 (0.96, 0.99) and 0.0011, respectively. Conclusions. The PNI was an independent predicting factor of 30-day, 90-day, and 1-year mortality of the critically ill patients with stroke. In addition, there was a U-shaped relationship between PNI and all-cause mortality of stroke patients. PNI was a risk factor for the outcome of stroke when PNI was >49.4, while PNI was a protective factor for outcome of stroke when PNI was <49.4.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

Liu

Yang

Kadasah

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…As regard to malignancy, two meta-analyses concluded that low GNRI level was correlated with poor overall survival in patients with gastrointestinal malignancy ( 30 ) and lung cancer ( 31 ). Other studies also found its prognostic value in hepatocellular carcinoma ( 32 ), renal cancer ( 33 ), bladder cancer ( 34 ), and lymphoma ( 35 , 36 ). Similarly, these results indicated clinical value of GNRI in nutrition assessment among elderly cancer patients.…”

Section: Discussionmentioning

confidence: 90%

Association of geriatric nutritional risk index with all-cause hospital mortality among elderly patients in intensive care unit

et al. 2023

View full text Add to dashboard Cite

BackgroundMalnutrition is associated with poor outcomes for geriatric patients in intensive care unit (ICU). It is important to identify patients at risk of malnutrition and provide individual nutrition support. The assessment of malnutrition risk is not easy for these patients due to their cognitive impairment. Geriatric nutrition risk index (GNRI) is a simple and objective scoring tool to evaluate the risk of malnutrition in elderly patients. In this study, we aimed to see whether GNRI score was appropriate to predict clinical outcomes among geriatric patients in the setting of ICU.Materials and methodsElderly patients with age ≥ 65 years were extracted from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Categories based on GNRI were classified as major risk (GNRI <82), moderate risk (GNRI 82 to <92), low risk (GNRI 92 to ≤98), and no risk (GNRI >98). The primary outcome was all-cause hospital mortality. Multivariable Cox proportional hazards regression models and restricted cubic spline were used to investigate associations of GNRI with hospital mortality, respectively. A two-piecewise linear regression model was applied to examine the inflection point of GNRI on hospital mortality. To reduce selection bias, propensity score matching (PSM) was used in a 1:1 ratio.ResultsA total of 3,696 geriatric patients were finally included with median age 75 (69, 81) years. The prevalence of major risk was 28.6%. In the fully adjusted model, GNRI categories featured a negative trend with hospital mortality (p for trend = 0.037). Restricted cubic spline analysis demonstrated an L-shaped relationship between GNRI and hospital mortality before and after matching. The inflection point was 78.7. At the left side of inflection point, GNRI levels were significantly negatively associated with hospital mortality (HR = 0.96, 95% CI: 0.94–0.98; p < 0.001) and featured no significant relations at the right side. Multiple linear regression also showed that GNRI was negatively associated with length of stay in hospital.ConclusionThe major risk of malnutrition defined by GNRI was able to predict poor prognosis for geriatric patients admitted to ICU.

show abstract

“…All the eligible articles were published between 2018–2022 ( 14 – 20 ). Three studies were conducted in Japan ( 14 , 16 , 18 ), two in China ( 15 , 19 ), and one each in Taiwan ( 17 ) and Turkey ( 20 ). The sample size was 133–615 (median, 267).…”

Section: Resultsmentioning

confidence: 99%

“…The threshold GNRI was 92-106.26 (median, 96.8). Six studies analyzed thresholds with receiver operating characteristic (ROC) curves (14, [16][17][18][19][20], while one study selected cut-off values according to the literature (15). Five studies were carried out in a single center (14, 15,17,19,20), and two were multicenter trials (16,18).…”

Section: Qualified Article Characteristicsmentioning

confidence: 99%

“…In recent years, numerous studies have analyzed the role of GNRI in predicting the prognosis of DLBCL cases ( 14 – 20 ), but their findings remain controversial. For example, in some studies, low GNRI significantly predicted poor survival in DLBCL patients ( 14 , 16 , 19 ). However, other researchers have reported that the GNRI is not related to DLBCL survival ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis

Cao

Zhang

2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundPrevious studies have explored the relationship between the geriatric nutritional risk index (GNRI) and survival outcomes of diffuse large B-cell lymphoma (DLBCL) cases, but the results were inconsistent. Consequently, the present meta-analysis was conducted to investigate how GNRI affects DLBCL and its function in terms of prognosis.MethodsThe Web of Science, PubMed, Embase, and Cochrane Library databases were thoroughly searched until January 18, 2023. We calculated combined hazard ratios (HRs) and 95% confidence intervals (CIs) to estimate the relationship between the GNRI and survival outcomes of patients with DLBCL.ResultsThis meta-analysis included seven articles involving 2,353 cases. A lower level of GNRI predicted dismal overall survival (HR=1.40, 95% CI=1.25–1.56, p<0.001) and inferior progression-free survival (HR=1.46, 95% CI=1.19-1.80, p<0.001) of DLBCL patients. Moreover, a low GNRI was significantly related to Eastern Cooperative Oncology Group Performance Status ≥2 (odds ratio [OR]=4.55, 95% CI=2.75–7.54, p<0.001), Ann Arbor stage III–IV (OR=2.91, 95% CI=2.38–3.57, p<0.001), B symptoms (OR=3.51, 95% CI=2.34–5.29, p<0.001), and extranodal disease (OR=2.90, 95% CI=2.32–3.63, p<0.001).ConclusionA lower GNRI level predicted poorer short- and long-term prognosis in patients with DLBCL. A low GNRI was correlated with clinical factors of disease progression in DLBCL patients.

show abstract

Prognostic values of geriatric nutritional risk index (GNRI) and prognostic nutritional index (PNI) in elderly patients with Diffuse Large B-Cell Lymphoma

Cited by 28 publications

References 27 publications

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

Association of geriatric nutritional risk index with all-cause hospital mortality among elderly patients in intensive care unit

Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis

Contact Info

Product

Resources

About