Prognostic Values of <i>CCNE1</i> Amplification and Overexpression in Cancer Patients: A Systematic Review and Meta-analysis

Zhao, Hongbo; Wang, Junling; Zhang, Yong; Yuan, Man; Yang, Shuangxiang; Li, Lisong; Yang, Huilin

doi:10.7150/jca.24179

Cited by 30 publications

(22 citation statements)

References 64 publications

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“…It is well-demonstrated that the dysregulation of CCNE1-CDK2 activity is implicated in multiple cancers, including bladder cancer, nasopharyngeal cancer and breast cancer [42–44]. It has also been demonstrated that overexpression of CCNE1 was related to poor prognosis in diverse of cancers [45]. Shaye and colleagues found that overexpression of CCNE1 is an early event in the progression of breast cancer [46].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression

et al. 2019

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BackgroundIn recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanisms of circRNAs in triple-negative breast cancer (TNBC) still remain largely unknown.MethodsHere, the expression profile of circRNAs in 4 pairs of TNBC tissues and adjacent non-tumor tissues was analyzed by RNA-sequencing. Quantitative real-time PCR and in situ hybridization were used to determine the level and prognostic values of circAGFG1 in two TNBC cohorts. Then, functional experiments in vitro and in vivo were performed to investigate the effects of circAGFG1 on tumor growth and metastasis in TNBC. Mechanistically, fluorescent in situ hybridization, dual luciferase reporter assay, RNA pull-down and RNA immunoprecipitation experiments were performed to confirm the interaction between circAGFG1 and miR-195-5p in TNBC.ResultsWe found that circAGFG1 was evidently up-regulated in TNBC, and its level was correlated with clinical stage, pathological grade and poor prognosis of patients with TNBC. The results indicated that circAGFG1 could promote TNBC cell proliferation, mobility and invasion as well as tumorigenesis and metastasis in vivo. Mechanistic analysis showed that circAGFG1 may act as a ceRNA (competing endogenous RNA) of miR-195-5p to relieve the repressive effect of miR-195-5p on its target cyclin E1 (CCNE1).ConclusionsOur findings suggest that circAGFG1 promotes TNBC progression through circAGFG1/miR-195-5p/CCNE1 axis and it may serve as a new diagnostic marker or target for treatment of TNBC patients.Electronic supplementary materialThe online version of this article (10.1186/s12943-018-0933-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression

et al. 2019

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“…The complex of cyclin-dependent kinase 2 (CDK-2) and cyclin E is essential to drive G1/S transition (Malumbres & Barbacid, 2009). Cyclin E1overexpression seems to be associated with poor survival of cancer patients (Zhao et al 2018). A study in prostate cancer cells suggested that downregulation of cyclin E1 suppresses proliferation and induces G1/S arrest (Zhang et al 2019), which is in line with our results.…”

Section: Wb-ems-conditioned Serum From Colorectal Cancer Patients Attsupporting

confidence: 89%

Physical activity and advanced cancer: evidence of exercise‐sensitive genes regulating prostate cancer cell proliferation and apoptosis

Schwappacher

Schink

Sologub

et al. 2020

The Journal of Physiology

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Key points Physical activity is known to protect against cancer. The resistance exercise method whole‐body electromyostimulation (WB‐EMS) has a significant anti‐cancer effect. WB‐EMS‐conditioned serum from advanced prostate cancer patients decreased human prostate carcinoma cell growth and viability in vitro. Multiplex analysis revealed that genes associated with human prostate cancer cell proliferation and apoptosis are sensitive for exercise. Feasible exercise should be part of multimodal anti‐cancer therapies, also for physically weakened patients. Abstract Regular physical activity is known to protect against cancer development. In cancer survivors, exercise reduces the risk of cancer recurrence and mortality. However, the link between exercise and decreased cancer risk and improved survival is still not well understood. Serum from exercising healthy individuals inhibits proliferation and activates apoptosis in various cancer cells, suggesting that mechanisms regulating cancer cell growth are affected by exercise. For the first time, we analysed serum from advanced‐stage cancer patients with prostate (exercise group n = 8; control group n = 10) or colorectal (exercise n = 6; control n = 6) cancer, after a 12‐week whole‐body electromyostimulation training (20 min/session, 2×/week; frequency 85 Hz; pulse width 350 µs; 6 s stimulation, 4 s rest), a tolerable, yet effective, resistance exercise for physically weakened patients. We report that serum from these advanced cancer patients inhibits proliferation and enhances apoptosis of human prostate and colon cancer cells in vitro using cell growth and death assays (5‐bromo‐2′‐deoxyuridine incorporation, cell counting, DNA fragmentation). Exercise‐mimicking electric pulse stimulation of human primary myotubes showed that electric pulse stimulation‐conditioned myotube medium also impairs human cancer cell viability. Gene expression analysis using a multiplex array of cancer‐associated genes and subsequent quantitative RT‐PCR revealed the presence of exercise‐sensitive genes in human prostate cancer cells that potentially participate in the exercise‐mediated regulation of malignant cell growth and apoptosis. Our data document the strong efficiency of the anti‐oncogenic effects of physical activity and will further support the application of regular therapeutic exercise during cancer disease.

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“…Amplification of CCNE1 is associated with many cancer progressions including gastric cancer, bladder cancer, ovarian cancer and triple negative breast cancer and linked to poor prognosis. [40][41][42][43] In this study, we found that CCNE1 is up-regulated in cervical cancer cells. Functional studies showed that CCNE1 play critical roles in cervical cancer cell growth and cell cycle transition from G1to S phase.…”

Section: Discussionsupporting

confidence: 51%

E6 hijacks KDM5C/lnc_000231/miR‐497‐5p/CCNE1 axis to promote cervical cancer progression

Zhang

et al. 2020

J Cellular Molecular Medi

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The prevalence of cervical cancer poses great threat to women's health. 1 Annually, over 500 000 patients were diagnosed with cervical cancer and approximately 300 000 died from this disease. 2-4 Due to the widely use of papanicolaou test for early cervical cancer screening and the advancement of therapeutic methods such as surgery operation, chemical treatment and radiotherapy, the incidence of cervical cancer has been reduced by 40%-50% in recent years. 5-7 However, for those advanced cervical cancer patients, the 5-year survival rate at the late stages can be as low as 15%. 8,9 Therefore, understanding the molecular mechanisms that initiate cervical cancer development and identifying new diagnostic markers are urgent for cervical cancer treatment, especially for those advanced cervical cancer patients. Nearly, all cervical cancer cases are linked to human papillomavirus (HPV) infection. Human papillomavirus is a small DNA tumour virus, consisting of a circular DNA molecule enclosed with capsid proteins. 10 Among all the genes encoded by HPV, E6 and E7 act as key oncogenes that promote tumour growth and malignant transformation. 11-14 Constitutive expression of E6/E7 immortalizes primary epithelial cells and promotes tumour formation in vivo. 15 E7 interacts with and stabilizes retinoblastoma tumour suppressor family (RB1 and RB2), facilitating cell cycle transition from G1 to S phase. 16 Similar to cell growth dysregulation, E6 interacting with ubiquitin ligase E6AP promotes tumour suppressor P53 degradation and cell proliferation. 17 Despite HPV infection, other cofactors also contribute to cervical cancer progression, such as immunosuppression, smoking, co-infection with HIV, co-infection with Chlamydia trachomatis and herpes simplex virus type 2 and other probable cofactors. 12

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Prognostic Values of CCNE1 Amplification and Overexpression in Cancer Patients: A Systematic Review and Meta-analysis

Cited by 30 publications

References 64 publications

RETRACTED ARTICLE: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression

RETRACTED ARTICLE: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression

Physical activity and advanced cancer: evidence of exercise‐sensitive genes regulating prostate cancer cell proliferation and apoptosis

E6 hijacks KDM5C/lnc_000231/miR‐497‐5p/CCNE1 axis to promote cervical cancer progression

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