Prognostic values of microRNA-130 family expression in patients with cancer: a meta-analysis and database test

Peng, Zhen; Duan, Fujiao; Yin, Jingjing; Feng, Yanping; Yang, Zhongyu; Shang, Jia

doi:10.1186/s12967-019-2093-y

Cited by 13 publications

(12 citation statements)

References 63 publications

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“…Differences in miR expression have not only been described in tissue biopsies, but also in blood samples of cancer patients [ 48 , 59 ]. As in tissues, some miRs have been proposed as potential blood biomarkers for cancer diagnosis and prognosis [ 60 , 61 , 62 , 63 ]. Previous studies have proposed using miR-145 as a biomarker of ovarian cancer because miR-145 serum levels are significantly down-regulated in patients with ovarian cancer and benign ovarian tumors, compared to healthy controls [ 38 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells

Garrido

Torres

Ávila

et al. 2020

IJMS

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Nerve Growth Factor (NGF) and its high-affinity receptor tropomyosin receptor kinase A (TRKA) increase their expression during the progression of epithelial ovarian cancer (EOC), promoting cell proliferation and angiogenesis through several oncogenic proteins, such as c-MYC and vascular endothelial growth factor (VEGF). The expression of these proteins is controlled by microRNAs (miRs), such as miR-145, whose dysregulation has been related to cancer. The aims of this work were to evaluate in EOC cells whether NGF/TRKA decreases miR-145 levels, and the effect of miR-145 upregulation. The levels of miR-145-5p were assessed by qPCR in ovarian biopsies and ovarian cell lines (human ovarian surface epithelial cells (HOSE), A2780 and SKOV3) stimulated with NGF. Overexpression of miR-145 in ovarian cells was used to evaluate cell proliferation, migration, invasion, c-MYC and VEGF protein levels, as well as tumor formation and metastasis in vivo. In EOC samples, miR-145-5p levels were lower than in epithelial ovarian tumors. Overexpression of miR-145 decreased cell proliferation, migration and invasion of EOC cells, changes that were concomitant with the decrease in c-MYC and VEGF protein levels. We observed decreased tumor formation and suppressed metastasis behavior in mice injected with EOC cells that overexpressed miR-145. As expected, ovarian cell lines stimulated with NGF diminished miR-145-5p transcription and abundance. These results suggest that the tumoral effects of NGF/TRKA depend on the regulation of miR-145-5p levels in EOC cells, and that its upregulation could be used as a possible therapeutic strategy for EOC.

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Section: Discussionmentioning

confidence: 99%

NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells

Garrido

Torres

Ávila

et al. 2020

IJMS

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“…The pharmacological inhibition of miR-130 family molecules by seed-targeting with an 8-mer tiny locked nucleic acid (LNA) inhibited bladder cancer cell growth, migration, and invasion by repressing stress fiber formation ( 173 ). Overall, miRNA-130 is highly expressed in patients with different types of cancer and is correlated with severe tumors and poor cancer prognosis ( 174 ).…”

Section: The Role Of Adipose Tissue Mirnas In Cancermentioning

confidence: 99%

The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer

2020

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Obesity is a multifactorial and complex condition that is characterized by abnormal and excessive white adipose tissue accumulation, which can lead to the development of metabolic diseases, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, cardiovascular diseases, and several types of cancer. Obesity is characterized by excessive adipose tissue accumulation and associated with alterations in immunity, displaying a chronic low-grade inflammation profile. Adipose tissue is a dynamic and complex endocrine organ composed not only by adipocytes, but several immunological cells, which can secrete hormones, cytokines and many other factors capable of regulating metabolic homeostasis and several critical biological pathways. Remarkably, adipose tissue is a major source of circulating microRNAs (miRNAs), recently described as a novel form of adipokines. Several adipose tissue–derived miRNAs are deeply associated with adipocytes differentiation and have been identified with an essential role in obesity-associated inflammation, insulin resistance, and tumor microenvironment. During obesity, adipose tissue can completely change the profile of the secreted miRNAs, influencing circulating miRNAs and impacting the development of different pathological conditions, such as obesity, metabolic syndrome, and cancer. In this review, we discuss how miRNAs can act as epigenetic regulators affecting adipogenesis, adipocyte differentiation, lipid metabolism, browning of the white adipose tissue, glucose homeostasis, and insulin resistance, impacting deeply obesity and metabolic diseases. Moreover, we characterize how miRNAs can often act as oncogenic and tumor suppressor molecules, significantly modulating cancer establishment and progression. Furthermore, we highlight in this manuscript how adipose tissue–derived miRNAs can function as important new therapeutic targets.

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“…Contrastingly, Kaplan-Meier analysis by Li B et al demonstrated that high expression of miR-130a in patients with hepatocellular carcinoma (HCC) had significantly improved OS [23]. In a recent meta-analysis, Peng et al evaluated 12 eligible studies comprising 1582 cases with various types of cancer, including HCC, colorectal cancer, gastric cancer, lymphoma, non-small-cell lung cancer, cervical cancer, cholangiocarcinoma, and osteosarcoma, and the pooled Journal of Oncology hazard ratios (HRs) indicated a significant relationship between the high levels of miR-130a expression and poor OS in cancer patients (HR � 1.58, 95%CI � 1.21-2.06, p < 0.001) [39]. Up to now, the prognostic role of miR-130a has not been investigated in OSCC.…”

Section: Discussionmentioning

confidence: 99%

Plasma-Derived Exosomal microRNA-130a Serves as a Noninvasive Biomarker for Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Guo

et al. 2021

Journal of Oncology

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Exosomal microRNAs (miRNAs) are considered as potential stable biomarkers in many types of human cancer, but investigations of plasma-derived exosomal miRNAs in oral squamous cell carcinoma (OSCC) are still lacking. The aim of this study is to evaluate the diagnostic and prognostic values of exosomal miR-130a in OSCC patients. Exosomes were isolated from plasma samples which were collected from 184 OSCC patients before surgery and 196 healthy individuals. Primary OSCC and paired adjacent noncancerous tissues were also obtained from 47 OSCC patients. The expression levels of miR-130a were analyzed by quantitative real-time PCR (qRT-PCR). Our results showed that the expression levels of exosomal miR-130a were significantly higher in OSCC patients than those of the healthy controls ( p < 0.0001 ). Also, the expression of miR-130a was also significantly upregulated in OSCC tissues compared with paired adjacent noncancerous tissues ( p < 0.0001 ). A significant positive correlation was found between exosomal miR-130a and tissue miR-130a levels. Receiver operating characteristic (ROC) analyses yielded an AUC value of 0.812 in discriminating OSCC patients from healthy controls. Furthermore, high levels of exosomal miR-130a were associated with the late T-stage ( p = 0.024 ), advanced TNM stage ( p = 0.003 ), and poorly differentiated OSCC ( p = 0.013 ). Patients with high exosomal miR-130a expression had significantly worse 3-year overall survival (OS) and recurrence-free survival (RFS). Multivariate analysis indicated that exosomal miR-130a was an independent prognostic factor for OS ( p = 0.001 ) and RFS ( p = 0.003 ). Our results suggest that exosomal miR-130a may serve as a promising diagnostic and prognostic biomarker for OSCC patients.

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Prognostic values of microRNA-130 family expression in patients with cancer: a meta-analysis and database test

Cited by 13 publications

References 63 publications

NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells

NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells

The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer

Plasma-Derived Exosomal microRNA-130a Serves as a Noninvasive Biomarker for Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

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