Prognostic Values of Platelet-Associated Indicators in Resectable Cervical Cancer

Wang, Jingmei; Wang, Ying; Huang, Yongzhen; Wang, Han; Zhu, Jie; Shi, Jianping; Li, Yifan; Wang, Jingjing; Wang, Wenjie

doi:10.1177/1559325819874199

Cited by 6 publications

(4 citation statements)

References 65 publications

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“…Shen et al [30] and Qin et al [31] reported that a decreased mean platelet volume was associated with CC development and could even be used as a screening tool. In patients with CC, a decreased mean platelet volume is also associated with a poorer prognosis, indicating more aggressive or advanced disease [32,33]. Platelets have complex relationships with cancer cells and contribute to tumor growth, angiogenesis, invasion, and dissemination [34,35].…”

Section: Discussionmentioning

confidence: 99%

Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection

Li,

Zhou,

Jiang

et al. 2024

BMC Cancer

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Background To investigate related factors for postoperative pathological upgrading of cervical biopsy to cervical cancer (CC) in patients with cervical intraepithelial neoplasia (CIN)3 after conical resection. Methods This retrospective study collected data from patients diagnosed with CIN3 by cervical biopsies at the author’s Hospital between January 2012 and December 2022. The primary outcome was the pathological results of patients after conical resection. The pathological findings were categorized into the pathological upgrading group if postoperative pathology indicated CC, while those with normal, inflammatory, or cervical precancerous lesions were classified into the pathological non-upgrading group. The factors associated with upgrading were identified using multivariable logistic regression analysis. Results Among 511 patients, there were 125 patients in the pathological upgrading group (24.46%). The patients in the upgrading group were younger (47.68 ± 9.46 vs. 52.11 ± 7.02, P < 0.001), showed a lower proportion of menopausal women (38.40% vs. 53.02%, P = 0.0111), a lower proportion of HSIL (40.00% vs. 57.77%, P = 0.001), a higher rate of HPV-16/18 positive (25.60% vs. 17.36%, P = 0.011), a higher rate of contact bleeding (54.40% vs. 21.50%, P < 0.001), lower HDL levels (1.31 ± 0.29 vs. 1.37 ± 0.34 mmol/L, P = 0.002), higher neutrophil counts (median, 3.50 vs. 3.10 × 109/L, P = 0.001), higher red blood cell counts (4.01 ± 0.43 vs. 3.97 ± 0.47 × 1012/L, P = 0.002), higher platelet counts (204.84 ± 61.24 vs. 187.06 ± 73.66 × 109/L, P = 0.012), and a smaller platelet volume (median, 11.50 vs. 11.90 fL, P = 0.002).The multivariable logistic regression analysis showed that age (OR = 0.90, 95% CI: 0.86–0.94, P < 0.001), menopausal (OR = 2.68, 95% CI: 1.38–5.22, P = 0.004), contact bleeding (OR = 4.80, 95% CI: 2.91–7.91, P < 0.001), and mean platelet volume (OR = 0.83, 95% CI: 0.69–0.99, P = 0.038) were independently associated with pathological upgrading from CIN3 to CC after conical resection. Conclusion Age, menopausal, contact bleeding, and mean platelet volume are risk factors of pathological upgrading from CIN3 to CC after conical resection, which could help identify high risk and susceptible patients of pathological upgrading to CC.

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Section: Discussionmentioning

confidence: 99%

Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection

Li,

Zhou,

Jiang

et al. 2024

BMC Cancer

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“…It is already known that thrombocytosis can be a prognostic factor in gynecological tumors. [15][16][17] One study found that pretreatment thrombocytosis may be an independent prognosis predictor in women with cervical cancer and may be a prognostic biomarker. 18 Another study demonstrated that the association of platelet count and FIGO stage increased the prediction performance of FIGO staging and may provide additional risk stratification for operable cervical cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…3 The main risk factor for the development of cervical cancer is infection by the HPV virus (human papillomavirus) and its oncogenic subtypes. HPV DNA is found in about 97% of cervical tumors and subtypes 16,18,31,35,39,45,51,52,56, and 58 cause the majority of invasive tumors. 4 HPV has been suggested as the first identifiable and necessary cause of cancer in humans, that is, cervical neoplasia does not develop in the absence of persistent HPV DNA.…”

Section: Introductionmentioning

confidence: 99%

HPV and Systemic Response in Cervical Intraepithelial Neoplasia

Silva,

Gomes,

Mantoani

et al. 2023

Arch Health Invest

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Objectives: to verify whether there is an association of low and high-risk HPV with blood count parameters in patients with cervical intraepithelial neoplasia. Methods: We prospectively evaluated 48 patients with Pap smear showing low or high-grade intraepithelial lesion, submitted to collection of material to perform PCR for high-risk and low-risk HPV. The following blood count parameters were evaluated: hemoglobin, red blood cells, hematocrit, absolute number of leukocytes, neutrophils, lymphocytes, eosinophils, basophils, monocytes and platelets, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and Red Cell Distribution Width (RDW). Receiver operating characteristic (ROC) curve was used to obtain the area under the curve (AUC) relating the positivity or not of HPV with the blood count parameters evaluated. Mann-Whitney test and multivariate analysis were performed, with level of significance less than 0.05. Results: Relating the positivity or not of HPV with the blood count parameters (Roc curves), there was statistical significance only between high-risk HPV and the platelet count (sensitivity=75%, specificity=66.7%, AUC=0.674, p=0.039). Platelet count ≤ 177,000/mm3 is associated with high-risk HPV. Subsequently, the multivariate analysis was performed, and the absolute value of platelets was considered an independent variable in this association with high-risk oncogenic HPV. Conclusion: A systemic response is found with the presence of high-risk HPV in CIN. Thus, platelet count ≤ 177,000/mm3 is associated with high-risk HPV.

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“…Studies have shown that PLR is a negative prognostic marker in advanced cancer [6]. MPV is associated platelet activation and production as well as the mean platelet volume in the blood [7,8]. Studies revealed that MPV is closely related with many types of cancer such as colon, thyroid and, renal cell carcinoma [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

"Prognostic Significance of Mean Platelet Volume to Lymphocyte Ratio in Patients with Metastatic Colon Cancer"

Şahinli¹

2021

BJSTR

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Background:The tumor microenvironment has become a very important in cancer progression. Immune cells in peripheral blood are essential elements of this environment. The prognostic significance of Mean Platelet Volume to Lymphocyte Ratio (MPVLR) in patients with metastatic colon cancer is unknown. Our aim is to investigate the prognostic significance of MPVLR.Methods: A total of 116 patients with metastatic colon cancer were analyzed retrospectively between January 2014 and December 2020. The relationship between clinicopathological variables and MPVLR has been assessed with chi-square test. Log rank test and cox regression analysis were used for univariate and multivariate analysis. The best cut-off value of MPVLR for overall survival was determined by ROC curve analysis. Results:The number of patients with MPVLR less than or equal to 5.4 was 39 (33.6%), and those with MPVLR above 5.4 was 77 (66.4%). Survival was worse in patients with MPVLR above 5.4 compared to patients below 5.4 (Hazard ratio (HR), 2.791; 95% Cl, 1.511-5.515, P = 0.001). The median survival could not be obtained in patients with MPVLR less than 5.4, while it was found as 22 months in patients with MPVLR above 5.4. There was no significant difference in progression-free survival between the two groups (HR, 1.181; 95% Cl, 0.776-1.797, p = 0.433). Conclusion:We found a shorter overall survival in patients with metastatic colon cancer with a high MPVLR value. This retrospective study is the first to investigate the prognostic significance of MPVLR for overall survival in patients with metastatic colon cancer.

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Prognostic Values of Platelet-Associated Indicators in Resectable Cervical Cancer

Cited by 6 publications

References 65 publications

Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection

Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection

HPV and Systemic Response in Cervical Intraepithelial Neoplasia

"Prognostic Significance of Mean Platelet Volume to Lymphocyte Ratio in Patients with Metastatic Colon Cancer"

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