Prognostic Values of Platelet Distribution Width and Platelet Distribution Width-to-Platelet Ratio in Severe Burns

Abstract

Background: Platelet distribution width (PDW) and PDW-to-platelet ratio (PPR) have been proven to be good prognostic indicators for many diseases. However, their prognostic values in severe burns have not been reported. Objective: To investigate the early time course of PDW and PPR in severe burn patients and investigate their prognostic values. Methods: This is a 16-year, single-center retrospective study of 590 severe burn patients. The complete blood count parameters on day 1, day 3, and day 7 postburn, including PDW and PPR, were collected. Receiver operating characteristic curves (ROC) analysis, multiple logistic regression analysis and Kaplan-Meier survival analysis were performed to evaluate the prognostic values of PDW and PPR in severe burn patients. Results: According to 120-day follow-up records, 96 patients were nonsurvivors and 494 patients were survivors. ROC and area under the curve (AUC) analysis showed that, for predicting 120-day prognosis, the AUC of PDW (0.782) and PPR (0.816) on day 3 was the highest, followed by the AUC of PDW (0.764) and PPR (0.750) on day 7. The ROC-AUC of PPR (0.816) on day 3 was very close to that of the ABSI score (0.818). Multiple logistic regression analysis showed that the PDW (P ¼ 0.033 and P ¼ 0.009) and PPR (P ¼ 0.052 and P ¼ 0.046) on day 3 and day 7 were all significantly independently positively associated with 120-day mortality. Kaplan-Meier survival analysis showed that high PDW and PPR were both significantly associated with a high 120-day mortality rate on day 3 and day 7. Conclusion: PDW and PPR on day 3 and day 7 were independent risk factors for 120-day mortality in severe burn patients. These objective and readily available prognostic indicators may be more clinically favored.

Platelet distribution width associated with short‐term prognosis and cost in paediatrics with partial‐thickness thermal burns: A retrospective comparative study

“…27 It has been showed PDW was an independent risk factor for 120-day mortality in severe burn patients. 28 Moreover, we found that burn wound area was also an independent factor associated with wound healing, which was consistence with previous study. 29 Besides wound healing, medical cost is another consideration for burn wound care.…”

“…A High PDW level indicts a higher production of larger reticulated platelets, which have larger and more metabolical activity, may promote the healing process of burn wound 27 . It has been showed PDW was an independent risk factor for 120‐day mortality in severe burn patients 28 . Moreover, we found that burn wound area was also an independent factor associated with wound healing, which was consistence with previous study 29 …”

Prognostic value of platelet count-related ratios on admission in patients with pyogenic liver abscess

“…Some studies have indicated that patients with severe sepsis/septic shock have lower platelet count [12]. The prognostic ability of platelet count-related indices has been investigated in a variety of diseases, such as cancers, sepsis and liver cirrhosis [13][14][15][16]. The platelet count-related ratios may be a more promising biomarker of inflammation than conventional indicators.…”

Práticas De Cuidado Dos Remanescentes De Quilombo Do Município De Oriximiná, Baixo Amazonas

“…Essa ativação, faz com que os fragmentos fiquem esféricos e exibam pseudópodes durante o processo de ativação para facilitar a aderência a outras plaquetas e a células lesadas, aumentando os valores da largura de distribuição de plaquetas (PDW) e volume plaquetário médio (VPM). Caso o estado do paciente continue a agravar, maior a proliferação heterogênea de megacariócitos e maior a presença de ativação plaquetária (Lin et al, 2021).…”

“…A quantificação da linhagem imatura por meio do Delta Neutrophil Index (DNI) reflete o estímulo medular intenso (Ahn, 2018). Já o fenômeno de ativação plaquetária pode ser identificado a partir da verificação do Volume Plaquetário médio (VPM) e Platelet Distribution Width (PDW), ambos associados a formação de eventos trombóticos juntamente com a redução do nível plaquetário (Lin et al, 2021). Outros parâmetros hematológicos, como as razões leucocitárias, avaliam a depleção de linfócitos associado à contagem de plaquetas e neutrófilos, refletindo as complicações originadas pelo distúrbio (Hou, 2021).…”