Prognostic values of regulatory T cells (Tregs) and Treg-related genes in gastric cancer

Zheng, Lirong; Li, Lin; Song, Jintian; Chen, Lizhu; Li, Hui; Ma, Ning; Chen, Qingyue; Chen, Yigui

doi:10.5114/ceji.2023.126773

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…High-density tumor-infiltrating Tregs may promote hepatocellular carcinoma progression and reduce survival by promoting angiogenesis 88 . In addition, Tregs were significantly elevated in the tissues of gastric cancer patients, affecting the survival prognosis of gastric cancer patients 89 . The pRRophetic analysis showed that the high-risk group was sensitive to cytotoxic chemotherapy such as cisplatin and paclitaxel, in contrast to the low-risk group, which was sensitive to gefitinib.…”

Section: Discussionmentioning

confidence: 99%

A novel necroptosis related gene signature and regulatory network for overall survival prediction in lung adenocarcinoma

Wang,

Liu,

Liu

et al. 2023

Sci Rep

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We downloaded the mRNA expression profiles of patients with LUAD and corresponding clinical data from The Cancer Genome Atlas (TCGA) database and used the Least Absolute Shrinkage and Selection Operator Cox regression model to construct a multigene signature in the TCGA cohort, which was validated with patient data from the GEO cohort. Results showed differences in the expression levels of 120 necroptosis-related genes between normal and tumor tissues. An eight-gene signature (CYLD, FADD, H2AX, RBCK1, PPIA, PPID, VDAC1, and VDAC2) was constructed through univariate Cox regression, and patients were divided into two risk groups. The overall survival of patients in the high-risk group was significantly lower than of the patients in the low-risk group in the TCGA and GEO cohorts, indicating that the signature has a good predictive effect. The time-ROC curves revealed that the signature had a reliable predictive role in both the TCGA and GEO cohorts. Enrichment analysis showed that differential genes in the risk subgroups were associated with tumor immunity and antitumor drug sensitivity. We then constructed an mRNA–miRNA–lncRNA regulatory network, which identified lncRNA AL590666. 2/let-7c-5p/PPIA as a regulatory axis for LUAD. Real-time quantitative PCR (RT-qPCR) was used to validate the expression of the 8-gene signature. In conclusion, necroptosis-related genes are important factors for predicting the prognosis of LUAD and potential therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

A novel necroptosis related gene signature and regulatory network for overall survival prediction in lung adenocarcinoma

Wang,

Liu,

Liu

et al. 2023

Sci Rep

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Clinical significance of peripheral blood immune cells in patients with gastric cancer after surgery

Wang,

Zhu,

Gong

2024

World J Gastrointest Surg

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BACKGROUND Gastric cancer is one of the most common malignant tumors worldwide, and surgical resection is one of the main ways to treat gastric cancer. However, the immune status of postoperative patients is crucial for prognosis and survival, and immune cells play an important role in this process. Therefore, it is helpful to understand the immune status of postoperative patients by evaluating the levels of peripheral blood immune cells, especially total T cells (CD3+), helper T cells (CD3+CD4+), and suppressor T cells (CD3+CD8+), and its relationship to survival. AIM To analyzed the immune cells in peripheral blood of patients with gastric cancer after surgery, detect the levels of total T cells, helper T cells and suppressor T cells. METHODS A total of 58 patients with gastric cancer who received surgical treatment were included in the retrospective study. Flow cytometry was used to detect the level of peripheral blood immune cells and analyze the correlation between total T cells, helper T cells and inhibitory T cells. To explore the relationship between these immune markers and patient survival. RESULTS The results showed that the levels of total T cells, helper T cells, and suppressor T cells changed in patients after gastric cancer surgery. There was a significant positive correlation between total T cells, helper T cells and suppressor T cells (r = 0.35, P < 0.01; r = 0.56, P < 0.01). However, there was a negative correlation between helper T cells and suppressor T cells (r = -0.63, P < 0.01). Follow-up showed that the survival rate of patients in the high-level total T cell group was significantly higher than that in the low-level group (28.87 ± 24.98 months vs 18.42 ± 16.21 months). The survival curve shows that the curve of patients in the high-level group is shifted to the upper right, and that of the low-level group is shifted downward. There was no significant difference between the levels of helper T cells and suppressor T cells and patient survival time. CONCLUSION By detecting peripheral blood immune cells with flow cytometry, we can initially evaluate the immune status of patients after gastric cancer surgery and initially explore its relationship with patient survival.

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Prognostic values of regulatory T cells (Tregs) and Treg-related genes in gastric cancer

Cited by 2 publications

References 33 publications

A novel necroptosis related gene signature and regulatory network for overall survival prediction in lung adenocarcinoma

A novel necroptosis related gene signature and regulatory network for overall survival prediction in lung adenocarcinoma

Clinical significance of peripheral blood immune cells in patients with gastric cancer after surgery

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