Prognostication of Recovery of Consciousness in Patients in a Vegetative State Using Proton Magnetic Resonance Spectroscopy

Kondratyeva, E. A.; Diment, S. V.; Kondratyev, S. A.; Иванова, Н. Е.; Bukkieva, T. A.; Efimtsev, A. Yu.; Труфанов, Г. Е.; Kondratyev, A. N.; S, Laurens

doi:10.1007/s11055-020-00972-5

Cited by 1 publication

(2 citation statements)

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“…Most studies [3, 5, 13–19, 21, 23, 24, 26, 31, 32, 35, 36, 39, 40] investigated the prognostic role of demographic, clinical and anamnestic factors. Some studies also included neurophysiological [5, 16, 19, 20, 22, 23, 25, 28, 30, 32, 33, 38] or neuroimaging [15, 26, 29, 37–39] investigations. Most often the outcome was assessed by clinical observation or by validated clinical or functional disability scales administered by professionals.…”

Section: Resultsmentioning

confidence: 99%

“…The details of the included studies are reported in Table S1. Most studies [3,5,14,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] enrolled patients in Europe (23/30, 77%), whereas five studies [15,[36][37][38][39] (16%) included patients from China, and two studies [13,40] (7%) included patients from the Americas.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Long‐term clinical evolution of patients with prolonged disorders of consciousness due to severe anoxic brain injury: A meta‐analytic study

Magliacano

Bellis

Panico

et al. 2023

Euro J of Neurology

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Background and purposeThe prognosis of prolonged (28 days to 3 months post‐onset) disorders of consciousness (pDoC) due to anoxic brain injury is uncertain. The present study aimed to evaluate the long‐term outcome of post‐anoxic pDoC and identify the possible predictive value of demographic and clinical information.MethodThis is a systematic review and meta‐analysis. The rates of mortality, any improvement in clinical diagnosis, and recovery of full consciousness at least 6 months after severe anoxic brain injury were evaluated. A cross‐sectional approach searched for differences in baseline demographic and clinical characteristics between survivors and non‐survivors, patients improved versus not improved, and patients who recovered full consciousness versus not recovered.ResultsTwenty‐seven studies were identified. The pooled rates of mortality, any clinical improvement and recovery of full consciousness were 26%, 26% and 17%, respectively. Younger age, baseline diagnosis of minimally conscious state versus vegetative state/unresponsive wakefulness syndrome, higher Coma Recovery Scale Revised total score, and earlier admission to intensive rehabilitation units were associated with a significantly higher likelihood of survival and clinical improvement. These same variables, except time of admission to rehabilitation, were also associated with recovery of full consciousness.ConclusionsPatients with anoxic pDoC might improve over time up to full recovery of consciousness and some clinical characteristics can help predict clinical improvement. These new insights could support clinicians and caregivers in the decision‐making on patient management.

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Section: Resultsmentioning

confidence: 99%