PROGRAD – An observational study of the prognosis of inpatients evaluated for palliative radiotherapy

Chen, André Tsin Chih; Mauro, Geovanne Pedro; Gabrielli, Flavia; Chaves, Cristiane de Lacerda Gonçalves; Castro, I.O.R.; Vasconcelos, Kamilla; Reis, Milena; Saraiva, T.; Carvalho, Helotônio

doi:10.1016/j.radonc.2018.03.021

Cited by 6 publications

(6 citation statements)

References 21 publications

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“…Using the Palliative Prognostic Index (PPI) and the Number of Risk Factors (NRF) score, they were able to stratify the patients into three groups with different prognoses. PPI score seemed to be the one that best discriminated those patients with the worst prognosis (22).…”

Section: Discussionmentioning

confidence: 97%

30-Day Mortality Following Palliative Radiotherapy

et al. 2021

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Purpose30-day mortality (30-DM) is a parameter with widespread use as an indicator of avoidance of harm used in medicine. Our objective is to determine the 30-DM followed by palliative radiation therapy (RT) in our department and to identify potential prognosis factors.Material/MethodsWe conducted a retrospective cohort study including patients treated with palliative RT in our center during 2018 and 2019. Data related to clinical and treatment characteristics were collected.ResultsWe treated 708 patients to whom 992 palliative irradiations were delivered. The most frequent primary tumor sites were lung (31%), breast (14.8%), and gastrointestinal (14.8%). Bone was the predominant location of the treatment (56%), and the use of single doses was the preferred treatment schedule (34.4%). The 30-DM was 17.5%. For those who died in the first month the median survival was 17 days. Factors with a significant impact on 30-DM were: male gender (p < 0.0001); Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 2–3 (p = 0.0001); visceral metastases (p = 0.0353); lung, gastrointestinal or urinary tract primary tumors (p = 0.016); and single dose RT (p = <0.0001). In the multivariate analysis, male gender, ECOG PS 2–3, gastrointestinal and lung cancer were found to be independent factors related to 30-DM.ConclusionOur 30-DM is similar to previous studies. We have found four clinical factors related to 30-DM of which ECOG was the most strongly associated. This data may help to identify terminally ill patients with poor prognosis in order to avoid unnecessary treatments.

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Section: Discussionmentioning

confidence: 97%

30-Day Mortality Following Palliative Radiotherapy

et al. 2021

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“…However, they found that dose of hemostatic RT < 30 Gy (HR 2.853 [1.360–5.987], p = 0.061) and bleeding score grade 2–4 at end of treatment (HR 6.456 [2.645–16.202], p = 0.061) negatively influenced survival. Of note, the significance of performance status was recently highlighted in a large prospective Brazilian study (PROGRAD) [20] , which evaluated the prognosis of inpatients assessed for palliative RT using two prediction scores [21] , [22] .…”

Section: Discussionmentioning

confidence: 99%

Short-course palliative radiation therapy leads to excellent bleeding control: A single centre retrospective study

Ning

Jhingran

Lin

et al. 2019

Clinical and Translational Radiation Oncology

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“…The study population was divided into three groups using historically used PPI cutoff values of 2 and 4 (i.e., ≤ 2, 2.5–4, and > 4) [4] , [5] . The Kaplan–Meier method was employed to estimate the overall survival, which was defined as the time from enrollment until death from any cause.…”

Section: Discussionmentioning

confidence: 99%

“…PPI is a straightforward, easy-to-use tool that considers factors such as performance status (PS), oral intake, edema, dyspnea at rest, and delirium. Historically, PPI cutoff values of 2 or 4 have been employed to predict the short-term survival of various cancer patients [4] , [5] . Notwithstanding the abundance of studies on prognosis prediction in patients with various advanced cancer [6] , [7] , [8] , [9] , [10] , to our knowledge, no study has specifically investigated prognosis prediction in patients with advanced gastric cancer treated with palliative radiotherapy.…”

Section: Introductionmentioning

confidence: 99%