“…In such settings, differences in early and continued training, support for the implementers, and differences in the aptitude of the implementers can lead to variation in implementation. The intervention implementers, who are typically not under the control of the research team the way they are in efficacy trials, are likely to deliver the program with varied fidelity, more adaptation, and less regularity than that which occurs in efficacy trials (Dane and Schneider, 1998;Domitrovich and Greenberg, 2000;Harachi et al, 1999). Traditional intent-to-treat analyses which do not adjust for potential variations in implementation, fidelity, participation, or adherence, are often supplemented with "as-treated" analyses, mediation analysis, and other post-assignment analyses described elsewhere (Brown and Liao, 1999;Jo, 2002;MacKinnon, 2006).…”