2022
DOI: 10.1021/acssensors.2c01648
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Programmable Millifluidic Platform Integrating Automatic Electromembrane Extraction Cleanup and In-Line Electrochemical Detection: A Proof of Concept

Abstract: A fully automatic millifluidic sensing platform coupling in-line nonsupported microelectromembrane extraction (μ-EME) with electrochemical detection (ECD) is herein proposed for the first time. Exploiting the features of the second generation of flow analysis, termed sequential injection (SI), the smart integration of SI and μ-EME–ECD enables (i) the repeatable formation of microvolumes of phases for the extraction step in a membrane-less (nonsupported) arrangement, (ii) diverting the acceptor plug to the ECD … Show more

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Cited by 4 publications
(8 citation statements)
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“…The flow rate for handling the liquid plugs and generating the OP/AP interface was set here to 60 μL/min. Higher flow rates had detrimental effects on the phase formation process because a large amount of OP became scattered around the walls or across the T-connection, which was aligned with our previous findings indicating that flow rates >30 μL/min might jeopardize the reliability of the three (DP/OP/AP) plugs using 1-nonanol as the OP . The inability to use flow rates >30 μL/min using 1-nonanol could be associated with its higher viscosity compared to octanol.…”
Section: Resultssupporting
confidence: 87%
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“…The flow rate for handling the liquid plugs and generating the OP/AP interface was set here to 60 μL/min. Higher flow rates had detrimental effects on the phase formation process because a large amount of OP became scattered around the walls or across the T-connection, which was aligned with our previous findings indicating that flow rates >30 μL/min might jeopardize the reliability of the three (DP/OP/AP) plugs using 1-nonanol as the OP . The inability to use flow rates >30 μL/min using 1-nonanol could be associated with its higher viscosity compared to octanol.…”
Section: Resultssupporting
confidence: 87%
“…3.5 mm long plug, measured experimentally, avoided the collapse of the threephase system while enduring high voltage and the dynamic flow-through DP mode. It should be noted that a minute volume of 1-octanol is lost through the formation of a wetting film throughout the connecting PTFE tubing walls, 19,39 thus the experimental volume (24 μL) is larger than the theoretical value (ca. 18 μL).…”
Section: ■ Results and Discussionmentioning
confidence: 89%
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