Programmed and self-organized flow of information during morphogenesis

Collinet, Claudio; Lecuit, Thomas

doi:10.1038/s41580-020-00318-6

Cited by 229 publications

(199 citation statements)

References 186 publications

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“…The original approach to investigate cellular population dynamics has mainly been deterministic, i.e., a stable genetic code defines cell fate as a programmed hierarchical process. More recently, research has shown how another group of mechanisms based on stochastic self-organisation plays a complementary role in morphogenesis (i.e., organ development) and cell development [ 41 ]. Under this perspective, genetic factors would interact with self-organisation mechanisms to balance the growth of an organism and the organisation of cellular assemblies in direct connection with environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Cancer Niches and Their Kikuchi Free Energy

Sajid

Convertino

Friston

2021

Entropy

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Biological forms depend on a progressive specialization of pluripotent stem cells. The differentiation of these cells in their spatial and functional environment defines the organism itself; however, cellular mutations may disrupt the mutual balance between a cell and its niche, where cell proliferation and specialization are released from their autopoietic homeostasis. This induces the construction of cancer niches and maintains their survival. In this paper, we characterise cancer niche construction as a direct consequence of interactions between clusters of cancer and healthy cells. Explicitly, we evaluate these higher-order interactions between niches of cancer and healthy cells using Kikuchi approximations to the free energy. Kikuchi’s free energy is measured in terms of changes to the sum of energies of baseline clusters of cells (or nodes) minus the energies of overcounted cluster intersections (and interactions of interactions, etc.). We posit that these changes in energy node clusters correspond to a long-term reduction in the complexity of the system conducive to cancer niche survival. We validate this formulation through numerical simulations of apoptosis, local cancer growth, and metastasis, and highlight its implications for a computational understanding of the etiopathology of cancer.

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Section: Discussionmentioning

confidence: 99%

Cancer Niches and Their Kikuchi Free Energy

Sajid

Convertino

Friston

2021

Entropy

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“…Most of the current work in the mechanobiology field is devoted to the understanding of how forces drive the arrangement of cells in space such as cell intercalation, cell migration, or collective cell migration during self-organization and spreading of tissues. From those studies we know how forces produced by oriented cell division and growth, directed cell crawling or bending of cell sheets, integrate local cell shape changes (for reviews see Heisenberg and Bellaïche, 2013 ; Collinet and Lecuit, 2021 ). However, how such mechanical forces influence cell fate is still an open question.…”

Section: Cell and Tissue Mechanics During Embryonic Developmentmentioning

confidence: 99%

Interplay Between Notch and YAP/TAZ Pathways in the Regulation of Cell Fate During Embryo Development

Engel-Pizcueta

Pujades

2021

Front. Cell Dev. Biol.

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Cells in growing tissues receive both biochemical and physical cues from their microenvironment. Growing evidence has shown that mechanical signals are fundamental regulators of cell behavior. However, how physical properties of the microenvironment are transduced into critical cell behaviors, such as proliferation, progenitor maintenance, or differentiation during development, is still poorly understood. The transcriptional co-activators YAP/TAZ shuttle between the cytoplasm and the nucleus in response to multiple inputs and have emerged as important regulators of tissue growth and regeneration. YAP/TAZ sense and transduce physical cues, such as those from the extracellular matrix or the actomyosin cytoskeleton, to regulate gene expression, thus allowing them to function as gatekeepers of progenitor behavior in several developmental contexts. The Notch pathway is a key signaling pathway that controls binary cell fate decisions through cell–cell communication in a context-dependent manner. Recent reports now suggest that the crosstalk between these two pathways is critical for maintaining the balance between progenitor maintenance and cell differentiation in different tissues. How this crosstalk integrates with morphogenesis and changes in tissue architecture during development is still an open question. Here, we discuss how progenitor cell proliferation, specification, and differentiation are coordinated with morphogenesis to construct a functional organ. We will pay special attention to the interplay between YAP/TAZ and Notch signaling pathways in determining cell fate decisions and discuss whether this represents a general mechanism of regulating cell fate during development. We will focus on research carried out in vertebrate embryos that demonstrate the important roles of mechanical cues in stem cell biology and discuss future challenges.

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“…As the stiffness of ECM is sometimes attributed to the abundance of collagen [123], which can be realistically modeled as a viscoelastic material with quantifiable storage and loss moduli [124], cell-matrix interactions and resulting cell migration thus exhibit dynamic time-dependent mechanical responses [105]. Paths of migration and areas that cells migrate toward are likely of different viscosity in addition to higher elasticity, thereby impacting the timescale of the responses of migrating cells to stiffness gradients [125]. To elucidate the effect of ECM viscosity on cell movements, several in vitro studies have either isolated the effects of the viscosity of substrates or implemented tunable storage-to-loss moduli ratios of substrates.…”

Section: Durotaxis and Viscotaxismentioning

confidence: 99%

Existing and Potential Applications of Elastography for Measuring the Viscoelasticity of Biological Tissues In Vivo

et al. 2021

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Mechanical tissue properties contribute to tissue shape change during development. Emerging evidence suggests that gradients of viscoelasticity correspond to cell movement and gene expression patterns. To accurately define mechanisms of morphogenesis, a combination of precise empirical measurements and theoretical approaches are required. Here, we review elastography as a method to characterize viscoelastic properties of tissue in vivo. We discuss its current clinical applications in mature tissues and its potential for characterizing embryonic tissues.

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Programmed and self-organized flow of information during morphogenesis

Cited by 229 publications

References 186 publications

Cancer Niches and Their Kikuchi Free Energy

Cancer Niches and Their Kikuchi Free Energy

Interplay Between Notch and YAP/TAZ Pathways in the Regulation of Cell Fate During Embryo Development

Existing and Potential Applications of Elastography for Measuring the Viscoelasticity of Biological Tissues In Vivo

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