Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes

Fortunato, Stephen J.; Menon, Ramkumar; Bryant, C Eileen; Lombardi, S.

doi:10.1067/mob.2000.107330

Cited by 139 publications

(82 citation statements)

References 16 publications

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“…Firstly, production and release of inflammatory cytokines may lead to increased prostaglandin secretion [5,12]. Secondly, pPROM and its consequence -preterm labour may be initiated by many factors such as infection, drugs or others [13]. There is also an evidence sup- Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…The role of MMPs in human labour and pPROM has been a subject of considerable study over the last decade. Increased collagenolysis, a drop in the collagen content of the membranes and activation of MMPs have been documented during active stage of labour [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical characteristics of four groups of studied patients Group I -patients at gestational age without any symptoms of preterm labour; Group II -threatened preterm labour patients; Group III -preterm vaginal delivery; Group IV -term vaginal delivery Table 2. The mean values ( SD) total MMP-8 serum concentrations in each study group Group I -patients at gestational age without any symptoms of preterm labour; Group II -threatened preterm labour patients; Group III -preterm vaginal delivery; Group IV -term vaginal delivery porting the implication of matrix metalloproteins and their depredating enzymes in the processes of preterm and term labour as well as that of pPROM [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

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Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Kuć

Lemancewicz²,

Laudański³

et al. 2010

Folia Histochem Cytobiol.

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Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I -pregnant women at 24-34 weeks of gestation with any symptoms of threatened preterm labour; II -threatened preterm labour patients between 24-34 weeks of gestation; III -preterm vaginal delivery patients; IV -healthy term vaginal delivery patients. Serum concentration of total MMP-8 was measured using two enzyme-linked immunosorbent assays. There were no significant differences in the median concentrations of total MMP-8 between physiological pregnancy and threatened preterm labour patients with existing uterine contractility. No significant differences of total MMP-8 were either found between healthy term and preterm labouring patients. The studies on a larger population are needed to reject the hypothesis that preterm labour is connected with increased MMP-8 plasma concentrations of women in preterm labour and threatened preterm delivery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Kuć

Lemancewicz²,

Laudański³

et al. 2010

Folia Histochem Cytobiol.

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“…Moore et al, 2009b;Menon et al, 2004;Zaga et al, 2004). Several groups have proposed the synergistic effects of MMP activation and apoptosis leading to rupture of the FM (McLaren et al, 2000a;Fortunato et al, 2000;Bowen et al, 2002;Lei et al, 1996). The promoter polymorphisms in some cytokines (TNF and IL-1 ) and MMPs (-1,-8,-9) have been identified to be associated with PPROM (Ferrand et al, 2002;Fujimoto et al, 2002;Hernandez-Guerrero et al, 2003;Roberts et al, 1999).…”

Section: Term Fm Develops a Para-cervical "Weak Zone" Where Rupture Imentioning

confidence: 99%

Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics

Rangaswamy¹,

Kumar²,

Moore³

et al. 2012

Preterm Birth - Mother and Child

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“…The causes of PTB are multiple, but intra-amniotic infection and chorioamnionitis are thought to be a major cause of spontaneous preterm labor (PTL) and preterm premature rupture of the fetal membranes (PPROM). Extensive data from the literature have reported mechanisms involving a feed-forward loop network in normal parturition, where proinflammatory cytokines are able to stimulate production of PGs and thereby uterine contractions and to upregulate matrix metalloproteinase (MMP) activation and programmed cell death (apoptosis), leading to the weakening and the rupture of the fetal membranes (2)(3)(4)(5).…”

mentioning

confidence: 99%

Functional Screening of TLRs in Human Amniotic Epithelial Cells

Gillaux

Méhats

Vaiman

et al. 2011

The Journal of Immunology

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Intrauterine infection is a major cause of spontaneous preterm birth. Amniotic epithelial cells represent the first line of defense against intra-amniotic bacteria. We hypothesize that this epithelial cell barrier is able to recognize and respond to pathogens through the function of TLRs, which are crucial regulators of the innate immune system. In this study, we describe the expression of transcripts for TLR1–TLR10 in human amniotic epithelial cells. We show that amniotic epithelial cells express functional TLR5, TLR6/2, and TLR4. Activation by TLR5 and TLR6/2 agonists produces IL-6 and IL-8, concomitantly with the activation of NF-κB signaling pathway, matrix metalloproteinase-9 induction, and PTGS2 expression. In contrast, TLR4 activation reduced amniotic epithelial cell viability and induced cell apoptosis evidenced by an elevated Bax/Bcl-2 ratio and cleavage of caspase-3. These data suggest specific TLR-mediated functions in human amniotic epithelial cells for initiating different immune responses, which ultimately may lead to preterm birth.

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Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes

Cited by 139 publications

References 16 publications

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics

Functional Screening of TLRs in Human Amniotic Epithelial Cells

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