Programmed Cell Death, from a Cancer Perspective: An Overview

Mishra, Abhay Prakash; Salehi, Bahare; Sharifi‐Rad, Mehdi; Pezzani, Raffaele; Kobarfard, Farzad; Sharifi‐Rad, Javad; Nigam, Manisha

doi:10.1007/s40291-018-0329-9

Cited by 141 publications

(116 citation statements)

References 105 publications

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“…The non‐small‐cell lung carcinoma includes approximately 75% of lung cancers (Fossella et al, ). In recent years, the interest towards induction of apoptosis as a strategy to produce antitumor drugs has increased (Mishra et al, ). Finding an antitumor drug with an apoptosis‐inducing agent and specificity for tumor cells may be ideal (Salehi et al, ).…”

Section: Resultsmentioning

confidence: 99%

Carvacrol and human health: A comprehensive review

Sharifi‐Rad

Varoni

Iriti

et al. 2018

Phytotherapy Research

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438

261

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Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus aurantium bergamia), and other plants. Carvacrol possesses a wide range of bioactivities putatively useful for clinical applications such antimicrobial, antioxidant, and anticancer activities. Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety. The present review illustrates the state-of-the-art studies on the antimicrobial, antioxidant, and anticancer properties of CV. It is particularly effective against food-borne pathogens, including Escherichia coli, Salmonella, and Bacillus cereus. Carvacrol has high antioxidant activity and has been successfully used, mainly associated with thymol, as dietary phytoadditive to improve animal antioxidant status. The anticancer properties of CV have been reported in preclinical models of breast, liver, and lung carcinomas, acting on proapoptotic processes. Besides the interesting properties of CV and the toxicological profile becoming definite, to date, human trials on CV are still lacking, and this largely impedes any conclusions of clinical relevance.

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Section: Resultsmentioning

confidence: 99%

Carvacrol and human health: A comprehensive review

Sharifi‐Rad

Varoni

Iriti

et al. 2018

Phytotherapy Research

Self Cite

438

261

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“…Pathological angiogenesis of tumor, microvascular leakage and hypoxia-induced apoptosis in the central part of the tumor together lead to tremendous recruitment and activation of inflammatory cells, including macrophages, lymphocytes, neutrophils, and mast cells. These immune cells contribute to produce massive growth and pro-angiogenic factors and cytokines via communication with a complex network of signaling pathways [136][137][138]. The inflammatory cytokines interleukin-1α and interleukin-1β, as well as other angiogenic factors such as VEGF and MMPs, may implicate in angiogenesis, development of a tumor, and cancer metastasis [139,140].…”

Section: The Role Of Angiogenesis In Tumor Development and Metastasismentioning

confidence: 99%

The roles and role-players in thyroid cancer angiogenesis

et al. 2019

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Thyroid cancer is the most prevalent endocrine cancer worldwide. Angiogenesis, the formation of new blood vessels, plays a pivotal role in the development and progression of tumors. Over the past years, cancer research has focused on the ability of tumors to induce newly formed blood vessel, because tumor growth and the process of cancer metastasis mainly depends on angiogenesis. Tumor neovascularization occurs following the imbalance between pro-angiogenic and antiangiogenic factors until the tumor switches to an angiogenic phenotype. A number of signaling factors and receptors that are implicated in the regulation of angiogenesis have been identified and characterized; most notably, the vascular endothelial growth factors (VEGFs) family and their receptors, which are the main pro-angiogenic molecules during early development and in pathological conditions such as cancer. Although thyroid is a highly vascularized organ, angiogenic switch in tumors of this organ leads to the formation of a vast network of blood vessels that favors the dissemination of tumor cells to distant organs and results in deterioration of patient conditions. Accordingly, the identification of key angiogenic biomarkers for thyroid cancer can facilitate diagnosis, prognosis and clinical decision-making and also may help to discover targeting factors for effective cancer therapy as well as monitoring response to therapy. Hence, the main purposes of this review are to summarize the types and mechanisms of angiogenesis emphasizing the prominent factors implicated in thyroid cancer angiogenesis.

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“…Breast cancer was one of the first fields in the study of silymarin anticancer effects. Silymarin treatment on human breast carcinoma cells, MDA‐MB 468, led to a significant inhibition of cell growth, regardless of anchorage dependency, which was observed in a dose‐ and time‐dependent manner (Mishra et al, ; Zi et al, ). Then various studies evaluated silymarin effects in proliferation, invasion, and metastasis of breast cancers, alone or in combination with chemotherapeutics or other phytochemicals (Amiri et al, ; Bazzano et al, ; Bosch‐Barrera et al, ; Kim et al, ; Kim et al, ; Kim et al, ).…”

Section: Silymarin Anticancer Effects: What Has Been Discovered So Far?mentioning

confidence: 99%

Silymarin antiproliferative and apoptotic effects: Insights into its clinical impact in various types of cancer

Hosseinabadi

Lorigooini

Tabarzad

et al. 2019

Phytotherapy Research

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Silymarin is a complex extract isolated from the plant Silybum marianum, widely known for its prominent antioxidant and hepatoprotective effects, although increasing evidences have reported extraordinary antiproliferative and apoptotic abilities. As a result, several signaling pathways involved in cell cycle control, cell proliferation, and cell death have been deconvoluted as critical mechanisms. In this regard, cyclin and cyclin‐dependent pathways have been the most studied ones. Following that, apoptotic pathways, such as p53, Akt, STAT‐3, Ras, and caspases pathways, have been extensively studied, although other mechanisms involved in inflammation and angiogenesis have also been highlighted as silymarin‐likely targets in cancer therapy. Therefore, the main challenge of this review is to discuss the diverse molecular mechanisms for silymarin antiproliferative and apoptotic effects; most of them largely studied in various types of cancers so far. Clinical trials and combination therapies related to silymarin application in cancer prevention and treatment are presented as well.

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Programmed Cell Death, from a Cancer Perspective: An Overview

Cited by 141 publications

References 105 publications

Carvacrol and human health: A comprehensive review

Carvacrol and human health: A comprehensive review

The roles and role-players in thyroid cancer angiogenesis

Silymarin antiproliferative and apoptotic effects: Insights into its clinical impact in various types of cancer

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