Programmed Cell Death in Animal Development

Jacobson, Marcus; Weil, Miguel; Raff, Martin

doi:10.1016/s0092-8674(00)81873-5

Cited by 2,514 publications

(1,626 citation statements)

References 64 publications

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“…Apoptosis is a fundamental important biological process that is required to maintain the integrity and homeostasis of multicellular organism [1]. It seems that apoptosis is a predominant type of active cell death in the liver.…”

Section: Introductionmentioning

confidence: 99%

The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes

et al. 2001

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We reported in this manuscript that TGF-β1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-β1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-β1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-β1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-β1-mediated gene expression and apoptosis.

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Section: Introductionmentioning

confidence: 99%

The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes

et al. 2001

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“…Although our knowledge of the mechanisms involved in the regulation of this process has grown considerably in the last few years, our understanding of the function as well as the nature of the genes involved in this process remains incomplete (Jacobson et al, 1997;Nagata, 1997). Genetic studies in C. elegans have led to the identi®cation of three genes ced-3, ced-4 and ced-9 involved in the central regulation of the apoptotic process (Ellis and Horvitz, 1986;Ellis et al, 1991;Hengartner et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Bcl-X is the major pleiotropic anti-apoptotic gene activated by retroviral insertion mutagenesis in an IL-3 dependent bone marrow derived cell line

1998

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In order to identify genes capable of inhibiting apoptosis induced by di erent pathways, without inducing proliferation we have performed retroviral insertion mutagenesis in the IL-3 dependent bone marrow derived Baf-3 cell line. Out of 200 mutants obtained in three separate mutagenesis experiments, four mutants were resistant to multiple apoptosis inducing pathways (including growth factor starvation, staurosporine, etoposide and cyclosporin A) and did not proliferate in the absence of IL-3. These four mutants overexpress the bcl-X gene following a retroviral insertion 5' of the translation initiation site. These results indicate that the bcl-X gene is a major pleiotropic anti-apoptotic gene in Baf-3 cells. They also suggest that the Bcl-2 family of genes might be the only one capable of inhibiting apoptosis induced by multiple pathways without inducing cell proliferation.

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“…Macrophages acting as professional phagocytes are capable of engulfing apoptotic cells undergoing type I PCD without inducing inflammatory response. 14,15 Typical examples of this clearance are found during embryonic development when a large number of apoptotic cells are removed 16 and during clearance of apoptotic granulocytes in inflammation. 17 Many cells of different origin, including epithelial cells, can act as non-professional phagocytes and engulf apoptotic cells.…”

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confidence: 99%

Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes

et al. 2007

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MCF-7 cells undergo autophagic death upon tamoxifen treatment. Plated on non-adhesive substratum these cells died by anoikis while inducing autophagy as revealed by monodansylcadaverine staining, elevated light-chain-3 expression and electron microscopy. Both de novo and anoikis-derived autophagic dying cells were engulfed by human macrophages and MCF-7 cells. Inhibition of autophagy by 3-methyladenine abolished engulfment of cells dying through de novo autophagy, but not those dying through anoikis. Blocking exposure of phosphatidylserine (PS) on both dying cell types inhibited phagocytosis by MCF-7 but not by macrophages. Gene expression profiling showed that though both types of phagocytes expressed full repertoire of the PS recognition and signaling pathway, macrophages could evolve during engulfment of de novo autophagic cells the potential of calreticulin-mediated processes as well. Our data suggest that cells dying through autophagy and those committing anoikis with autophagy may engage in overlapping but distinct sets of clearance mechanisms in professional and non-professional phagocytes.

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Programmed Cell Death in Animal Development

Cited by 2,514 publications

References 64 publications

The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes

The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes

Bcl-X is the major pleiotropic anti-apoptotic gene activated by retroviral insertion mutagenesis in an IL-3 dependent bone marrow derived cell line

Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes

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